Bacterial chromosome biology, gene expression, pathogenicity... and football. @graingerlab.bsky.social
Birmingham, UK
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A new pre-print out - we show that promoters and terminators of transcription are frequently coupled, throughout the bacteria, and that this is regulatory.
biorxiv.org/content/10.64898…
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Bidirectional promoters in Escherichia coli: regulatory rules and implications for gene expression noise academic.oup.com/nar/article…
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In our most recent work David Forrest has discovered a widespread mechanisms linking transcription initiation to DNA supercoiling...
nature.com/articles/s41467-0…
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@emilywarmanj has followed up on her discovery of bidirectional promoters in bacteria by defining their basic rules for regulation and links to gene expression noise...
academic.oup.com/nar/article…
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A busy few weeks for the lab 🥵... three new stories published. The first describes activation of transcription by DNA distortion
academic.oup.com/nar/article…
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If you're interested in chromosome biology (DNA folding, gene regulation, replication, polymer modelling and more) we're organising the below this autumn. It'd be great to see you there. Please share if you can. :-)
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Giving these another airing... projects on bacterial pathogens, antimicrobial resistance, and basic mechanisms... all with a hint of gene regulation #PhD #opportunities
PhD projects available in our lab all listed in the below link. All focus on bacterial gene regulation, in the context of basic understanding, disease, or anitbiotic resistance. Deadlines in January...
findaphd.com/phds/?Keywords=…
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I can highly recommend Paul's lab's stuff... and I bet a lot of you didn't know GTAs existed (I didn't).
We have a fascinating preprint just out, revealing the widespread packaging of bacterial genomic DNA into capsids in the human gut:bit.ly/3B2ajza. Major denizens of the #microbiome implicated with broad potential impact on bacterial evolution and horizontal gene transfer
ALT Concept summary of the approach used in the present study. A. Diagram of a caesium chloride gradient tube of VLPs purified from human faecal samples. Two bands of different densities are illustrated, followed by a flow chart of the Oxford Nanopore sequencing process and an illustrative chart showing read length distributions typical of phage, transducing phage particles and gene transfer agents. B. Distributions of read lengths obtained from six faecal VLP fractions.
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PhD projects available in our lab all listed in the below link. All focus on bacterial gene regulation, in the context of basic understanding, disease, or anitbiotic resistance. Deadlines in January...
findaphd.com/phds/?Keywords=…
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We have a post-doc opportunity for a molecular microbiologist available. Please contact directly for an informal discussion.
jobs.ac.uk/job/DKH037/resear…
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Well done Ksenia, it's been a pleasure, let's get your paper written now 🙂
Today I became Dr. Ksenia! 🥳
Thanks a lot to my PI Dave Grainger, Steve Busby and all Grainger group @GraingerLab
It was awesome experience, best 4 years of PhD I could ever imagine 💫
And thanks to @JessicaMABlair and Yulia Yuzenkova for a wonderful viva 🙌🏻
@IMIBirmingham
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Well done @mulecc - your PhD work just published 😀nature.com/articles/s41467-0…
I think we've only scratched the surface with this... H-NS allowing bacteria to direct their own evolution. Exciting times ahead...
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If you haven't been to this before please consider coming along. The meeting has been running since 2012 and has been continually excellent.
#BioPhyChrom 2025 details announced
biochemistry.org/events-and-…
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Looks like colony sectoring. We seen stuff like this. I'd assume some individual cells are acquiring a genetic change as the colony grows then start to outcompete the wild type. Maybe pick from individual sectors, and centre of the whole colony, then long read sequence.
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3. Because essential and highly transcribed genes are not H-NS bound, they pick up transposons far less frequently. We think H-NS is protecting key genes by directing transposons elsewhere. (4/4)
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1. Because H-NS often binds pathogenicity islands, these DNA regions get switched on and off at low levels in populations when transposons insert. This is likely to be an important driver of heterogeneity on populations. (2/4)
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Really excited to share this. A massive effort from @mulecc.
We find that H-NS isn't just for gene silencing. All this time it's been busy capturing transposons, and inserting them into bound DNA.
We think there are some big implications (1/4)
biorxiv.org/content/10.1101/…
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We have a 3 year post-doc opportunity available. If you're interested in bacterial gene regulation and links with pathogenesis get in touch.
jobs.ac.uk/job/DEX508/resear…
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