Why your vitamin D supplement isn't working:
- Vitamin D is a pre-prohormone. Inactive on its own.
- The liver converts it to 25-hydroxy vitamin D. Still inactive.
- From there, two paths. The kidney can activate it to 1,25-dihydroxy vitamin D, which drives calcium absorption from the gut and suppresses inflammation.
- Or inflamed tissue (gut inflammation, sarcoid, TB) converts it to 24,25-dihydroxy D, which is inactive and gets excreted.
- Soft drinks, sugared and artificially sweetened, deplete vitamin D to begin with.
Deficiency is associated with chronic metabolic disease, but supplementing has not fixed it. If you're inflamed, the vitamin D you take never gets where you need it.
Dr. Robert Lustig (
@RobertLustigMD) on
@hubermanlab