Our group focuses on generating modified aptamers and developing chemoenzymatic methods for the synthesis of chemically modified, therapeutic oligonucleotides
Paris, France
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Great news!
Moderna cancer vaccine stops melanoma returning: what’s next for personalized treatments? nature.com/articles/d41586-0…
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Very happy to share a preprint on our contribution to identifying a polymerase capable of accepting heavily modified nucleotides. Great collaboration with Marc Delarue and @ChaputLab. Congrats to @MariaPozz1!
@DBSC_IP @institutpasteur @AgenceRecherche
biorxiv.org/content/10.64898…
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Very happy to share our new article published @ChemBioChem on enzymatic GalNAc-labelling of oligonucleotides. Big congrats to @pierrenicolas_b and all authors!
chemistry-europe.onlinelibra…
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Very happy to share our new manuscript @BioconjChem on the enzymatic synthesis of Glyco-DNA Equipped with Oligosaccharides and Charged Monosaccharides.
Congrats to @MariaPozz1 and Marc! @institutpasteur @CNRSchimie
pubs.acs.org/doi/10.1021/acs…
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Hollenstein group retweeted
Great visit and lecture at Institut Pasteur thanks to @Hollensteinlab invitation.
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Thrilled to share our recent pre-print where we studied the stereochemical outcome of phosphorothioate bond formation during ligation. Congrats to Erwann and @NazariiSabat. Great collaboration with @Roche.
@DBSC_IP @CNRSchimie chemrxiv.org/doi/full/10.264…
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Very happy to share our pre-print on the enzymatic synthesis of DNA equipped with short oligosaccharides. Great collaboration with Marc Delarue and Laurence Mulard. Congrats to Maria Dalla Pozza and Marc!
chemrxiv.org/doi/full/10.264…
@DBSC_IP @institutpasteur
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Very happy to share our recent article @ChemBioChem on the synthesis of Ru-complex modified DNA by copper-free click chemistry together with @GasserGroup
Congrats to all authors particularly Germain and Alix!
@institutpasteur @pierrenicolas_b @CNRS
chemistry-europe.onlinelibra…
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Thrilled to share our review article @TrendsChemistry on modified aptamers. Congrats to all authors! Great collaboration with @juliantanner1 .
doi.org/10.1016/j.trechm.202…
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Hollenstein group retweeted
Online now: Expanding the chemical repertoire of aptamers dlvr.it/TPfm3R
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Hollenstein group retweeted
Thrilled to share our article just published in @J_A_C_S on the selection of Ru-modified aptamers! Fantastic collaboration with @Hollensteinlab, congratulations to all authors!
doi.org/10.1021/jacs.5c13224
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Thrilled to share our article @J_A_C_S on the selection of Ru-modified aptamers! 7 years in the making. Congrats to all authors! Great collaboration with @GasserGroup
pubs.acs.org/doi/full/10.102…
@GermainNiogret @institutpasteur
@pierrenicolas_b
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Hollenstein group retweeted
I'm very happy to announce that our article has just been published online in Communications Chemistry!
Thank you @Hollensteinlab for giving me the opportunity to work on this project! 🧬
nature.com/articles/s42004-0…
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Hollenstein group retweeted
Probing three-dimensional cyclooctatetraene for nucleobase modification in aptamer selection bit.ly/46lknyH
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Interested by 3D modified aptamers? Then check out our recent article by undergraduate student Charlotte and postdoc Usman.
nature.com/articles/s42004-0…
@CNRS @institutpasteur @juliantanner1
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Very happy to share our preprint @ChemRxiv on the selection of Ru-modified aptamers. Long in the making. Congrats to all authors. Great collaboration with @GasserGroup and @Chrom_Inf
@institutpasteur @CNRS
go.shr.lc/4lOBL5J
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Very much looking forward presenting our research at #biotrans2025 in Basel. Thanks again for the kind invitation!
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Very happy to share out new pre-print on the enzymatic GalNAc-labelling of oligonucleotides. Big congrats to undergraduate student Elisa and graduate student @pierrenicolas_b !
chemrxiv.org/engage/chemrxiv…
@institutpasteur @CNRSchimie
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Hollenstein group retweeted
#ChemBioChem #OnTheCover Recent Advances in Biocatalytic and Chemoenzymatic Synthesis of Oligonucleotides (ChemBioChem 9/2025) (Marcel Hollenstein and co-workers) onlinelibrary.wiley.com/doi/… • onlinelibrary.wiley.com/doi/…
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Hollenstein group retweeted
ReNAissance : révolutionner les traitements antiviraux grâce à l’ARN messager
🤝 @CNRSchimie @CNRS_dr17 @CNRS_Meudon
👉 buff.ly/EVQo0Y6
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