Ever wonder how heterogeneity defines bladder cancer subtypes? Ha and Hsieh Lab postdoctoral fellows @pushpa_itagi and Samantha Schuster @fredhutch did, leading to a deep study of bladder cancer clonality, evolution, and heterogeneity published @Nature nature.com/articles/s41586-0…

Last chance to register for the ribosome heterogeneity and translation control meeting! Selected talks from abstracts and an outstanding lineup up of speakers. Please repost and register today!!

Excited to share that our work from RIKEN is now published in Nature! 🎉 We uncovered how protein intake during development shapes lifespan and identified a mechanism that transmits a “nutritional memory” into adulthood. nature.com/articles/s41586-0…

Remarkable. Grasping this complexity of metastatic dissemination takes some getting used to (brilliantly portrayed in fig 1).

We found an adrenergic iron–MSRA axis that regulates methionine redox signaling and adipose browning. Disrupting MSRA preserved tissue mass and prolonged survival in tumor-bearing mice. Huge congrats to Jung Seung Nam, who led this work! nature.com/articles/s43018-0…

Very happy to share our new paper in Nature Cancer. This project started with a simple question: what drives the early loss of adipose tissue during pancreatic cancer cachexia?

🧬 Fred Hutch Cancer Center is hiring an Assistant or Associate Professor in B Cell Immunology. Build an independent research program and advance discoveries in infectious disease prevention and human immunology. Apply: bit.ly/3UAoOn5

This is the first of multiple manuscripts that use our patented approach to increase protein production in gene specific way from a wild type allele in happloinsufficiencies using antisense oligonucleotides (ASOs). Great collaboration with @MillerLabNeuro and funded by @CZI. Many more manuscripts and ASOs to come in the near future. Protein expression is amplified by stabilizing mRNA using gene-specific antisense oligonucleotides biorxiv.org/content/10.64898…

Fred Hutch is recruiting an Assistant Professor in Cancer Prevention. We're seeking researchers focused on metabolism, nutrition, physical activity, toxicology and the biological mechanisms of carcinogenesis to advance cancer prevention science. Apply: apply.interfolio.com/191911

🧬 New @Nature study shows metastatic bladder cancer spreads via metastasis-to-metastasis seeding! ☢️Dominant metastases act as hubs for further spread, highlighting the power of ablative SBRT to disrupt this cycle and target key drivers of progression. 🔗 nature.com/articles/s41586-0…

Considering this pattern of metastatic spread, investigating the role of metastasis-directed therapy in bladder cancer becomes even more compelling. At @HumanitasMilano we have an ongoing randomized trial specifically addressing this question.

A potential role for radiotherapy to be explored in metastatic bladder cancer targeting all visible sites as met-to-met dissemination seems to be dominant. @drdavidpalma @Mat_Guc @ResearchWyatt

This is a beautiful piece of in vivo work @Dr_Di_Zhao . SASP hits again!

RT @uwmnewsroom: .@Nature: Reconstructing metastatic bladder cancer tumor evolution reveals cancer subtypes to improve future diagnostics,…

Fred Hutch and UW are recruiting a physician-scientist faculty member in Radiation Oncology. Help advance translational cancer research while delivering exceptional patient care and training the next generation of clinicians. Apply: apply.interfolio.com/192383

Thrilled to see our work over years in #bladdercancer published in @Nature THANKS to patients/families consenting to our research autopsy program wanting to support others! Kudos to @HsiehLab @GavinHa #OmarMian #MingLam et al. @fredhutch @HutchPresident nature.com/articles/s41586-0…

Published today in @Nature: A new Fred Hutch study using a first-in-kind rapid autopsy program shows details of metastatic bladder cancer subtypes; could improve diagnosis and future treatment. bit.ly/4xrNFra @pushpa_itagi @HsiehLab @GavinHa @DrOmarMian

Cancer treatment alters mutant selection in normal esophagus nature.com/articles/s41588-0…

Read more about the work here: fredhutch.org/content/www/en… via @fredhutch @HsiehLab @GavinHa

Congratulations on the publications!

How does bladder cancer spread? 🔬 New work published today in @Nature uses clonal tracing to show that new metastases are predominantly seeded by an earlier metastasis, potentially highlighting a critical window for intervention with metastasis-directed therapies. @fredhutch