Are you paying attention #IACI??? We need to learn from this!! #chronic #Lyme #LongCOVID #MECFS keep reading thread from here and make sure you see the potential of feeding the GSTA4 enzyme glutathione. Awesome research learning about therapeutics for rejuvenation from stem cells
Y. Ryan Lu
@Y_Ryan_Lu
5 Sep 2025
Replying to @Y_Ryan_Lu
12/ Mechanistically, GSTA4 detoxifies 4-HNE, a lipid peroxidation byproduct that progressively accumulates in aging RPE. Unlike generic antioxidants that just mop up ROS, GSTA4 repairs the damage.

Sep 6, 2025 · 12:55 AM UTC

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Replying to @ImmunoFever
Glad you find it relevant Michal:) 4-HNE is indeed associated with the severity and outcomes of many infections and diseases. I fully agree that GSTA4 and glutathione precursors should be investigated to mitigate these conditions. Let us know if you need help.
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Yes! We need so much help! It's a huge problem and we're collecting powerful clinical samples through our MAESTRO study and we also have a mouse model of chronic Lyme disease where we leave B6 or C3H mice infected with Borrelia and the C3H are literally falling apart. Interested?
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Replying to @ImmunoFever
Love seeing 4-HNE in this - so much growing polyunsaturated fat breakdown byproduct stuff... 4-HNE transformed proteins (American high-PUFA & fried food diet) + 'stimulus event' (ie COVID-19) -- autoimmunity vs 4-HNE-transformed proteins? Fix the diet, fix the problem. But also explaining *why* many people on these diets are not harmed! Need an extra tolerance break even to a food-induced protein transformation.
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Replying to @ImmunoFever
Been taking glutathione in all forms (including IV) for more than a year now. No improvements at all.
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Replying to @ImmunoFever
Wow, this is epic IMO and TBH 😵‍💫🫠😮🙂‍↔️🫡🙋‍♀️ By the way, thank you my woman&science idol @ImmunoFever for bringing this to my attention 🫡🙋‍♀️🙏💙🔥
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Replying to @ImmunoFever
Indeed, the focus on GSTA4 and its interaction with glutathione presents a promising avenue for therapeutic intervention in chronic conditions like Lyme disease, Long COVID, and MECFS.
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Replying to @ImmunoFever
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