I gave Claude fable 5.5 one prompt: a video of all human progress, then 30 years into the future. It came back with a 3-minute animated film and an original score. No footage, no stock music.

How ARPA-H is planning to cut clinical trial times from 10+ years to <4 years: 1. 'Phaseless' clinical trials - move towards replacing phase 1 → 2 → 3 with adaptive trials that can cut failed drugs (or advance good ones) faster. 2. Simulate trial outcomes before starting, with digital twins - to reduce reliance on large control groups. 3. AI agents for trial operations. 4. Turn ordinary hospitals into reusable clinical trial sites, and gets AIs to flag eligible trials to doctors and patients.

Bill Gates not having it with the liability talk

i don't know how anyone can watch this clip and not immediately lose whatever respect for Huang that they ever had, irrespective of their opinions on AI "software breaks out of sandboxes all the time, that's the reason why we need virtual machines" complete and total bullshit

Fields Medalist Cédric Villani june 2026: llms are not intelligent and understand nothing of what they say september 19: i was shaken by openai's solution to the millennium problem. an atmosphere of the end of history. it's a cataclysm unlike anything mathematics has ever known

openai, and its researchers, are being irresponsible

We Must Pace the Frontier: I’ve written a new essay on why the AI industry should slow down, with a three-part plan for doing so. Anthropic is unilaterally committing to the first of these steps. We’ll provide third-party evaluators with permanent, employee-level access to our systems, so that they can verify adherence to our safety measures, report on incidents, and assess models’ alignment during training. You can read the full post here: darioamodei.com/post/we-must…

Verified U.S. clinicians can get free GPT-6 Astra (Pro) access today via ChatGPT for Clinicians. Sign up: chatgpt.com/plans/clinicians…

Any updates on this

if you value intelligence above all other human qualities, you’re gonna have a bad time

I told myself I’d never join X. But I can no longer ignore my own responsibility to raise awareness of just how narrow this window is, and how critical alignment & monitorability is right now. What is coming IS sobering and I stress that everyone needs to level up their game to meet it. Working on Agent Security @OpenAI has been extremely intense the past few months, but I am humbled by how seriously my colleagues across the lab take it. The “AI community” needs to spend less time arguing about who cares more about safety / alignment and more time working together to do this right. Read Jakub’s post. Then read it again. And then do your part to do something about it. openai.com/index/an-alien-mi…

I wrote about the state of AI, why I’m concerned about the next few years, and the choices we need to make to keep the future in humanity’s hands. An Alien Mind: openai.com/index/an-alien-mi…

AGI achieved externally

*Tapping the sign*

Neoclouds have limited cybersecurity. Next time agents successfully go rouge, they'll try taking over a neocloud to run more copies. This is bad. Thus: neoclouds should greatly strengthen their cybersecurity and every company with strong cyber models should help with that.

anthropic employees doing mech interp work on mythos 8

I had a friend living there at the time. She was at breakfast with some friends and she texted her parents in CA 'Hey, I'm going on a hike so no service- wanted to say have a great day and I love you!' and then they went and sat by a waterfall to wait bc what else could they do?

this is gonna sound ridiculous but it didn’t even occur to me that Dolly Parton could die