The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, neurobiology. Est. 1896 - @RockUPress
New York, NY
- Tweets 18,803
- Following 1,163
- Followers 35,316
- Likes 8,650
Yang Yu, Yanling Zhao, Zhongcheng Shi, Larry L. Wang et al. demonstrate that CAMKV, previously classified as a nonfunctional pseudokinase, possesses intrinsic kinase activity driven by MYC/MYCN oncogenes to promote #neuroblastoma growth. hubs.la/Q04ykZ360
1
1
2
1,100
Insights: Sajiki, Araki et al. (hubs.la/Q04ykYf40) show that long-lived naive #CD8 #Tcells accrue tonic #TCR signaling during homeostasis, driving their differentiation into functionally superior effectors. From Hee Yeun Won & Jung-Hyun Park: hubs.la/Q04ykYhq0
6
25
1,830
New Review: Tomás S. Huerta, @KevinJTraceyMD, Isaac M. Chiu & @changsbrain review the organization & function of vagal neuroimmune circuits, from afferent cytokine sensing to organ-specific efferent immune control. hubs.la/Q04ykWBh0
#BioelectronicMedicine #Neuroimmunology
6
16
2,302
✍️💻 Participate in a complimentary Journal-Based #CME activity that consists of a full-text article that is free to read, a multiple-choice question test, and an evaluation/self-assessment. Our latest CME Activity @MSKCME is NOW available 👉 hubs.la/Q04wgC0S0
1
4
1,071
📢 We're now accepting applications for the JEM Early Career Travel Award, for grad students & early-career postdocs to participate in #VIB #Neuroimmunology Conference @VIBTrainConf in Antwerp!
Deadline ⏰ October 16, 2026
Apply here 👉 hubs.la/Q04xTnCC0
4
9
1,298
Ovezgeldiyev, Trefzer, Doolan, Bouchery et al. reveal a metabolic pathway linking lipid mediator production to #macrophage activation during #helminth immunity. hubs.la/Q04xS7d70
#Metabolism #InnateImmunity #inflammation #InfectiousDisease #HostDefense
1
6
22
1,735
Florez-Paz & Mentis demonstrate the presence of supernumerary synapses during development, resulting in miswired immature spinal circuits. Two molecularly distinct mechanisms are responsible for their refinement, incl. a surprising CD47-dependent mechanism hubs.ly/Q04xFWyB0
1
6
1,253
Zhang et al. identify RalA-dependent signaling as a regulator of age-related #skeletalmuscle dysfunction. The novel compound UA-30 inhibits RalA activity, reduces muscle #fibrosis, improves mitochondrial function & mobility, & extends survival in mice. hubs.ly/Q04xFVZX0
1
4
5
1,196
“JEM doubtlessly is among the most prestigious journals in the overall field of medicine and in particular for the fields of immunology and inflammation.” — Ignacio Melero @ClinicaNavarra
Learn more about submitting to a journal valued by the community: hubs.la/Q04xy3xQ0
1
4
6
1,299
Read Dr. Melero and colleagues’ JEM study TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment. rupress.org/jem/article/223/…
3
315
New content is available in our journal-based #CME activities @MSKCME: 📄 “Serotype skewing and immune imprinting shape response to the tetravalent dengue virus Qdenga vaccine” (Conde et al. hubs.la/Q04wfwBF0)
Begin the activity 👉 hubs.la/Q04wfFYR0
1
1
910
Explore our #cancer #Immunotherapy collection showcasing a broad range of topics, including the therapeutic potential of targeting cDC1, a strategy to harness the immunosuppressive potential of inhibitory receptors, and more: 👉 hubs.la/Q04v-Jnf0
1
7
1,304
The transcription factor IRF8 drives tumor-specific exhaustion in CD8⁺ T Cells. From Marco Ongaro, Grégory Verdeil and colleagues: hubs.la/Q04v_31w0
In our #CancerImmunotherapy 2026 👉 hubs.la/Q04v_32q0
#CSHAsia
7
37
2,571
Michalets et al. demonstrate that upper respiratory tract tissue-resident memory #CD8⁺ T cells are sufficient to protect against respiratory virus transmission, even in the absence of #CD4 #Tcells, #Bcells, or lower respiratory tract immune responses. hubs.la/Q04x7-HH0
1
8
28
1,833
Journal of Experimental Medicine retweeted
🔬NEW RESEARCH -How do our #cells maintain rapid bursts of #inflammation to fight #pathogens? 🔥 In this new #collaborative #paper with Prof Xiaopeng Qi @JExpMed, we show that the inflammatory signalling control centre within the cell, called the inflammasome, must be fueled. 1/3
ALT Vps4B controls caspase-1 dynamics at the ASC speck to drive inflammasome activation
1
4
22
1,021
Intravesical mesothelin-based #CARTcells targeting MUC16 effectively control #BladderCancer in preclinical models. By Parwiz Abrahimi, Renier Brentjens, Jedd Wolchok, Taha Merghoub et al hubs.la/Q04v-TF20
In our #CancerImmunotherapy 2026 👉 hubs.la/Q04v_0wY0
#CSHAsia
2
11
1,267
Li et al. identify that the ATPase Vps4B controls caspase-1 dynamics at the ASC speck to promote #inflammasome activation. This self-rejuvenating mechanism of the ASC speck opens up new avenues for therapeutic intervention in inflammatory diseases. hubs.la/Q04x2Pfh0
3
12
1,291
JEM is pleased to present opportunities to engage in #CME @MSKCME. The latest activity is now available 👉 hubs.la/Q04wfD_20
📄 New content: “Serotype skewing and immune imprinting shape response to the tetravalent dengue virus Qdenga vaccine” (hubs.la/Q04wfz6H0)
4
867
Journal of Experimental Medicine retweeted
4/ After leaving the lab, @ryangrui completed his pediatric residency at @WCMpeds and his Allergy and Immunology fellowship at @bcmhouston and @TexasChildrens. Our ongoing collaboration has yielded a study in @JExpMed on RORγT deficiency rupress.org/jem/article/223/…
1
1
15
815
Benjamin Ostendorf, Sohail Tavazoie @RockefellerUniv et al. show that activation of LXRs elicits a T cell "pre-effector" state that enhances priming and promotes anti-tumor immunity. hubs.la/Q04v-FW00
In our #CancerImmunotherapy 2026 👉 hubs.la/Q04v_2Q_0
#CSHAsia
1
8
17
1,343