Wow! This has been the huge question in #IACI mitochondrial dysfunction. If lactate is accumulating why won't the mitochondria just use that for fuel? Well... Guess what else is dysfunctional? Carnitine metabolism
Our body (cells) have fuel preference, e.g., burning fat vs. carbohydrates, which depends on the environment and nutritional states. How do cells decide which fuels to use? Our new study found that carnitine biosynthesis is crucial for fuel switching science.org/doi/10.1126/scie…
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Defects in carnitine metabolism, fatty acid metabolism, oxygen uptake, plus lactic acid accumulation.... I'm starting to wonder if anything about our metabolism is working correctly.
Jan 10, 2026 · 10:17 AM UTC
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