Our body (cells) have fuel preference, e.g., burning fat vs. carbohydrates, which depends on the environment and nutritional states. How do cells decide which fuels to use?  Our new study found that carnitine biosynthesis is crucial for fuel switching science.org/doi/10.1126/scie…

Jan 9, 2026 · 3:21 PM UTC

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Replying to @KajimuraLab
Impressive work!
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Replying to @KajimuraLab
You note the role of Thyroid hormone. Carnitine supplementation has been shown to help with fatigue among some people (with sufficient T3) with continuing symptoms despite treated hypothyroidism. pubmed.ncbi.nlm.nih.gov/2743… Are there implications for this population?
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Replying to @KajimuraLab
Can we get a public paper on this, without a paywall please?
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Replying to @KajimuraLab
Didn't Bruce Ames demonstrate this like 25 years ago or more?
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Replying to @KajimuraLab
Nice work on cellular fuel preference! Carnitine's role in fuel switching is critical, as it transports fatty acids into mitochondria for oxidation. What implications does this have for metabolic disorders? Do you see any therapeutic potential in modulating carnitine biosynthesis? For an in-depth review, check out sciqst.com, where you can generate comprehensive biomedical insights. #CellBiology #Metabolism
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Congrats Shingo! Beautiful work!
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Replying to @KajimuraLab
Congrats! Fascinating story!
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Replying to @KajimuraLab
Beatiful work, congratulations!
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Replying to @KajimuraLab
Congratulations
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