Professor of Medicine at Washington University| Studying lipid metabolism| Adipocyte Biology, BAT, Diabetes, NAFLD, Obesity, Peroxisomes| PhD UMICH
Saint Louis, Missouri
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Happy to share our new paper in @Nature led by staff scientist Xuejing Liu @Jessielxj2. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D
nature.com/articles/s41586-0…
@WashUDeptMed
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This is a top lab in the entire world. Join for the science, stay for the mentoring and camaraderie. @tsengyuhua
📢 Postdoc opening in the Tseng Lab @JoslinDiabetes @harvardmed! Explore how thermogenic adipocytes shape whole-body metabolism. Strong background in molecular/cell biology + metabolism required; adipocyte biology a plus. yhtsenglab.org/
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From a randomized trial, the advantage of a ketogenic diet vs Mediterranean or low fat plant diet for people with pre diabetes and fatty liver (hepatic steatosis)
cell.com/cell-metabolism/ful…
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New year resolution to post more! Proud of @yushengyeh & @RazaniLab members for their @atvbahajournals review this month comparing/contrasting newly discovered #adipocyte #lipolysis via #lysosome #LIPA vs. known cytoplasm #ATGL in #cardiometabolic #CVD 💪
ahajournals.org/doi/10.1161/…
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Excited to share our new publications working with @AlbertHKimMDPhD. We developed a stem cell model of glioblastoma (GBM) and uncovered how INSM1 programs a progenitor network that fuels GBM progression nature.com/articles/s41467-0…
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Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure | Science science.org/doi/10.1126/scie…
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Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation, and fibrosis in mouse models of MASH dlvr.it/TQJ9h0
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Our body (cells) have fuel preference, e.g., burning fat vs. carbohydrates, which depends on the environment and nutritional states. How do cells decide which fuels to use? Our new study found that carnitine biosynthesis is crucial for fuel switching science.org/doi/10.1126/scie…
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Peroxisome-dependent ether lipid down regulation is also a prominent feature of ME/CFS patient lipid profiles. Our prior work and this new study call for a clinical trial of sodium phenylbutyrate that can boost peroxisome function on Long COVID 🙏🙏@NIAIDNews
I find it interesting that sodium phenylbutyrate was found in this study and even @Jie_Immunology's science.org/doi/10.1126/scie… to help reverse this in lungs and now gut?
Clinical trial soon?
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Excited to see this work published in Nature Metabolism! This study provides new insight into how normally stable adipocytes can be mobilized under extreme metabolic stress, independent of sympathetic signaling. Congrats to @schellerlab and the team!
Very happy to start 2026 by sharing our new manuscript in Nature Metabolism.✨ By studying the constitutive adipocytes in the bone marrow, we identified a brain-mediated pathway that bypasses the SNS to evoke massive fat loss. 🧠🦴
Full article here: lnkd.in/gH7eHv4r
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Thank you @NIH for highlighting our recent @Nature paper! Extremely grateful for the support that made this work possible.
Unlike the white fat cells you may be familiar with, brown fat cells use energy to produce heat. NIH-supported researchers identified a previously unrecognized way these cells use energy. The findings suggest a potential way to promote weight loss by increasing heat generation in brown fat cells. bit.ly/3LSxeSK
ALT Infrared images of heat production from brown fat in a control mouse (left) and a mouse that lacks a protein called ACOX2 (right). Weisensee Lab
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Shingo, thanks so much for highlighting our recent paper! Looking forward to exploring this further.
Super interesting ! A new UCP1-independent thermogenic mechanism in peroxisomes sciencedirect.com/science/ar…
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New content online: Novel UCP1-independent thermogenic mechanism identified bit.ly/47jtFvZ
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Thrilled to share our work on adipose tissue heterogeneity out today in @emboreports! Huge congrats to first author Hoang Bui, Juli Hansen, and our special collaborator @valelosardo for guiding us through the mysterious world of single-cell analysis! embopress.org/doi/full/10.10…
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A consensus guide to preclinical indirect calorimetry experiments go.nature.com/4nkLRvR
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Happy to share new work led by outstanding former grad student Kubra Akkaya! Following up on our previous work, we show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell function and proliferation, shaping epithelial homeostasis and regeneration.
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I remember watching @LodhiLab @WashUMedEndo present this stunning work on peroxisomal thermogenesis at WashU and thinking "That's a Nature paper!" Now it is:
nature.com/articles/s41586-0…
And I like these "Briefings" that let the authors discuss their findings:
nature.com/articles/d41586-0…
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Out today in @CellReports! We found that coxsackievirus B3 (CVB3), which is associated with increased risk of #T1D, infects all human pancreas cell types, not just beta cells. Great collab with @hubert_tse KUMC. Led by @WashUdbbs PhD student @dveronese18 cell.com/cell-reports/fullte…
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Congrats Dr. Bahram Razani (@BahramRazani) on the official lab launch @UCSF @UCSFMedicine.
Looking forward to seeing Great things from the "other" Razani Lab! 😁
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