Jing Wang@JingWang0610

New York Structure Biology Center

 Manhattan, NY
Joined November 2018
Jing Wang retweeted
Chaoyou Xue@ChaoyouX
Jun 2
Excited to share our Molecular Cell paper on IS110 RNA-guided transposition! We reveal that IS110 uses two mechanistically distinct RNA-guided transposition pathways, advancing our understanding of programmable DNA integration. Free access link: authors.elsevier.com/a/1nCA9…
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Jing Wang retweeted
BaoLab@HuanBao4
26 Aug 2025
Our DeFrND approach is finally published. A simple trick to isolate membrane proteins with native lipids for structural and functional characterization. doi.org/10.1038/s41467-025-6…

DeFrND: detergent-free reconstitution into native nanodiscs with designer membrane scaffold peptides

Nature Communications - To bypass the limitations of detergents, Ren et al. developed peptide scaffolds that extract membrane proteins directly into lipid nanodiscs, preserving the native...

nature.com
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Jing Wang retweeted
Zhen Chen@ZhenChentccz
13 Feb 2024
Interested in studying cellular and development biology by advancing cryo-electron tomography? We have openings for postdocs to resolve in situ protein structures at the atomic scale: bbe.caltech.edu/jobs/postdoc…

Postdoctoral Position in Structural Cell Biology (Chen lab)

bbe.caltech.edu
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Try CryoCycling your grids today! Work led by X-less Slavic & a great, largely @SEMC_NYSBC  team: @JingWang0610, @eydchua, @IshemgulovaA, @AlinkMichael, Chase Buddell, Jake Johnston, Charlie Dubbeldam, Fabio Gonzalez, @sharonrozovsky, @edward_eng, @demarco_lab, & all who helped!
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authors.elsevier.com/c/1iSQ3… From Frank lab, a Cell paper today on time-resolve cryo-EM (TRCEM) method, with new chip design + biol. application: short-lived intermediates of the recycling process ...... Thanks to @OliBClarke @LomvardasLab for early postings.
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Jing Wang retweeted
deMarcoLab@demarco_lab
18 Jan 2024
Square beams square beams square beams. The article is finally out! doi.org/10.1038/s41592-023-0… Get yourself a square aperture and make your whole-cell tiled tomograms. Congratulation team! @eydchua Michael Alink, Misha Kopylov and Jake Johnston @SEMC_NYSBC
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Three-year post-doctoral position in our lab at Ecole Polytechnique, France
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Ever wonder if nature already 'invented' RNA-guided transcription factors like CRISPRi/a? Then look no further... we found many examples of domesticated, nuclease-dead TnpBs that use guide RNAs to repress genes! In bacteria AND phage! A wonderful team effort led by Tanner Wiegand
Sternberg Lab@SternbergLab
1 Dec 2023
New pre-print from the Sternberg Lab! Transposon-encoded nucleases (TnpB/IscB) gave rise to the CRISPR-associated proteins (Cas9 and Cas12), but were TnpB-like proteins domesticated for other functions? 𝙔𝙀𝙎!! doi.org/10.1101/2023.11.30.5…
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Remarkable work from the Sternberg Lab, led by the talented postdoc @TannerWiegand and colleagues, has led to the discovery of naturally occurring nuclease-deficient TnpBs (TldRs) that have been repurposed as programmable transcription factors!!
Sternberg Lab@SternbergLab
1 Dec 2023
New pre-print from the Sternberg Lab! Transposon-encoded nucleases (TnpB/IscB) gave rise to the CRISPR-associated proteins (Cas9 and Cas12), but were TnpB-like proteins domesticated for other functions? 𝙔𝙀𝙎!! doi.org/10.1101/2023.11.30.5…
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Exciting new work from the lab, on the marriage of transposons, CRISPR-like nucleases, guide RNAs, and self-splicing ribozymes! Check out the thread below from (Twitter-less) lead author, Rimante. A wonderful team effort biorxiv.org/content/10.1101/…

Antagonistic conflict between transposon-encoded introns and guide RNAs

TnpB nucleases represent the evolutionary precursors to CRISPR-Cas12 and are widespread in all domains of life, presumably due to the critical roles they play in transposon proliferation. IS605-fam...

biorxiv.org
Sternberg Lab@SternbergLab
22 Nov 2023
We’re beyond excited to share the newest pre-print from the Sternberg Lab! You thought all bacterial transposons (aka IS elements) were simple? Think again…🤓1/6
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The @SternbergLab on 🔥 ! What a cool story! If you are up for new CRISPR biology and beyond go work with @shsternberg and the rest of the team in cool NYC! @ColumbiaBiochem
Sternberg Lab@SternbergLab
22 Nov 2023
We’re beyond excited to share the newest pre-print from the Sternberg Lab! You thought all bacterial transposons (aka IS elements) were simple? Think again…🤓1/6
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Thrilled to share our work on how type V-K CRISPR-associated transposases (CASTs) select their target sites, now published in @ScienceMagazine! science.org/doi/full/10.1126… In this study, we've enhanced the accuracy of type V-K CASTs up to 99%.🧵 on the bioRxiv version below: #CRISPR
Jerrin Thomas George
@jerrintgeorge
17 Jul 2023
We are super excited to share our work unraveling the mechanistic intricacies of target site selection by type V-K CRISPR-associated transposases now available as a preprint on bioRxiv!🧬 biorxiv.org/content/10.1101/… 1/16
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Check out our latest: Using smFRET, we determine an entirely new mechanism for mRNA activation. As part of this work, we assign novel functions for each of the eIF4F components, including a 'hopping' activity of eIF4G and a 'strippase' activity of eIF4A. 🔬biorxiv.org/content/10.1101/…
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Jing Wang retweeted
Edward T Eng@edward_eng
31 Oct 2023
Replying to @SEMC_NYSBC @NCITUinfo @NCCATinfo @NCCAT2 @JingWang0610 @demarco_lab @gabang87
Halloween is another day at @SEMC_NYSBC. Holding meetings and helping users in costume doesn’t stop us from advancing biomedical research. @SEMC_NYSBC - Providing #cryoEM expertise & resources for understanding molecular & cellular structure
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Jing Wang retweeted
SEMC@SEMC_NYSBC
31 Oct 2023
Happy Halloween - Oct 31, 2023 👻 🎃 🍬
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Jing Wang retweeted
Rado Danev@RadoDanev
25 Oct 2023
Please RT - An opportunity to spend two months next summer in Japan and experience its culture and research environment. Please check out JSPS' summer program below. We will be more than happy to host you in our lab. 🗾🗻🏯🍙👺❄️🔬🙂👍
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Jing Wang retweeted
Zhen Chen@ZhenChentccz
20 Oct 2023
Our work is out @CellCellPress: sciencedirect.com/science/ar…. We used in situ cryoET to visualize proteins in sperm at 6 Å, and employed AlphaFold2 to identify novel proteins. It's an incredible experience to work with people from @HHMIJanelia @rmkaake @PolinaLishko @KroganLab.
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Jing Wang retweeted
Edward T Eng@edward_eng
3 Jul 2023
Ready to begin your profession in the structural sciences in NYC? @SEMC_NYSBC has openings for: -Staff microscopist -RNA Structural Biology postdoc -Proteomics postdoc or Staff scientist -3D-EM Image Analyst ...and more! See all our opportunities at: semc.nysbc.org/job-opportuni…
SEMC@SEMC_NYSBC
30 Jun 2023
Job opportunities @SEMC_NYSBC: semc.nysbc.org/job-opportuni… SEMC is a global leader in cryo electron microscopy (cryoEM) and provides expertise and resources for understanding both molecular and cellular structures.
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Do you have time-resolved cryoEM projects that need mixing 2 samples from 100-500ms? Email sramm@nysbc.org if Spotiton access may work for you. Please include a short paragraph briefly stating the project, the protein mass, & timescales of interest. Refs: PMIDs 32778833, 33720116
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Happy to share structure of human TRPV4 in complex with the GTPase RhoA. TRPV4-RhoA contact interface reveals residues that are mutated in neuropathies, providing insight into disease pathogenesis. Great collaboration with the lab of David Zhang (MCW). disq.us/t/4h6p0om
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