25% Owner of @TrustPointe. Chemist, Engineer, Business Owner, Corporate Veep. Interests include Finance, Science, Entrepreneurship. Views are my own.
Grand Rapids, MI
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Josh retweeted
Josh’s 10 reported results span 108.6–138.6% of label claim. A one-vial result could have made this order look very different, depending on which vial was picked.
I know someone asked for the raw assay values that went into content uniformity:
132.16%
133.22%
108.60%
132.23%
134.40%
134.58%
134.61%
138.63%
135.30%
132.33%
Based on this data, the 108 looks like a special cause (although not that special since the vial used for the assay result was 107%)
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Since my rando X contact for RT10s didn’t work out
Any peptide vendors on here want to send me 100 vials and get put through the @TrustPointe ringer?
Will be public, so you’ll have to be confident
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When we start running USP <788> on peptide vials, I fully expect to find high levels of glass and rubber particulates from unwashed vials.
Peptide prices will rise as people learn the risks and demand testing.
Paying $10 more per vial for clean product? Welcome trade.
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My RT10 buy from a rando on X is not going well. I know you are all shocked 😱
More bad news to come!
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USP 905 Content Uniformity is an FDA-USP test used to control dose-to-dose variation in dosage form (e.g. tablets, vials).
It requires 10 assay values, and two things must be true for it to pass:
1. All the values have to be between 90-110% of the claim
2. The vial to vial variation has to be low enough that you can statistically predict all the vials will be in that spec
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Why are there vials at 130% and some at 107%?
Few things could cause this:
> this is a mixed lot, even though I specifically requested all vials from one batch
> there were two different pieces of filling equipment used to fill this batch
> there was one piece of filling equipment with 8 filling heads and one is set wrong
> equipment is malfunctioning
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Regardless of the cause, USP <905> is a useful tool for measuring vial-to-vial variation in a batch
Provisional COA here (testing still pending): trustpointelims.com/TrustPoi…
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Well, USP <905> Content Uniformity on my RT10s from China FAILED
A 🧵
I ordered 100 RT10s from China.
Going to run a full set of testing on them, including USP <905> Uniformity of Dosage Units (10 vial assay for statistics).
I just want to have a single COA with every test we offer on it.
Will be something like 78 vials vials left over after
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This aged like milk
As I've been forecasting, a weak U.S. labor market, already massive and soaring federal debt, and the need to keep Japan from selling Treasuries mean the Fed won't hike rates no matter how far above 2% annual CPI gains rise. Inflation will become a much bigger problem. Got gold?
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“Wow, it’s amazing how you were able to get AI to create this dashboard.
Must save a lot of time! How long did it take to set up?”
“Three months, and I still have to double check the output. It’s a work in progress.”
😑
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Purity is a great litmus test for how much method development went into a lab’s methods
The lab with the lowest purity result has the most accurate method for that peptide
If you buy peptides and you aren’t demanding a COA from the right labs… good luck
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This is because of the science behind HPLC separations
It takes work to make the chromatogram on the left. Sometimes weeks, sometimes months. Tweaking gradient parameters, trying different columns, etc.
Any doof with an HPLC can make the chromatogram on the right in hours. Then use that same doofy method on 200+ peptides and get 99.9%+ purity on them all.
Made with AI
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Nah
Throw caution to the wind and inject that straight into your veins
That’s what bodybuilders have been doing for decades and they’re fine
do we really need to test every single vial from a Chinese factory? at this point, I’m spending money on testing that could be going toward buying more peptides lol
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What’s the haps on the craps
Shake ‘em up shake ‘em up shake ‘em up shake ‘em
Roll ‘em in a circle of methods and watch me break ‘em with a seven, 7-11, 7-11
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