Lab testing per US FDA requirements for consumer injectables • Accuracy Matters. Results You Can Trust. • FDA #3034276914 • Women-Owned Small Business

Dorr, MI
Today a client told us: “I use TrustPointe because I know if it passed your testing, my product would pass any other lab it was sent to.” We talk about method validation and forced degradation, but that’s probably the simplest description of our value (and a high compliment).
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There are no peptide resellers demonstrating content uniformity on their peptide batches today Clear differentiator, but only if your process is capable of meeting the high bar it represents
Well, USP <905> Content Uniformity on my RT10s from China FAILED A 🧵
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TrustPointe Analytics 🥼 retweeted
Well, USP <905> Content Uniformity on my RT10s from China FAILED A 🧵
I ordered 100 RT10s from China. Going to run a full set of testing on them, including USP <905> Uniformity of Dosage Units (10 vial assay for statistics). I just want to have a single COA with every test we offer on it. Will be something like 78 vials vials left over after
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Working on USP <1207> CCIT - Vacuum Decay. Machine is in the shop. Hoping to get down to 5um leak detection
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Had our first testing order come through Peptaura’s group buy testing crypto payment tool Honestly pretty cool how frictionless it is. Money and order shows up, we test and upload the COA to the order, done.
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TrustPointe Analytics 🥼 retweeted
We left dry retatrutide in a truck and on a sunny windowsill all summer. The fridge group got the VIP treatment. Then @TrustPointe tested the samples. High purity. Lower measured content outside the fridge. Randy brought receipts. 🐀👇 peptidecritic.com/lab-report…
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you’re paying for testing on the good ones too. And you’re paying for the allocation of risk off yourself. You can legally buy research chems for yourself and not get in trouble at all. There is no fine for buying bpc 157 for research purposes for YOURSELF. The RUO brands assume the risk for buying the chems and selling them under a thin guise and pass off the cost to the consumer for doing so. The other alternative is to find a good Chinese plug and cut out the middle man but the downsides are very little of them do 3rd party testing and many have MOQs or “kits” The allocation of risk and testing demands a premium that RUO vendors can pass off to consumers. Simple economics really.
Most peptide "brands" don't manufacture anything. They buy, relabel, and multiply the price. You're paying for a logo and a landing page.
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Any good LIMS recommendations? About to set a match to mine
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TrustPointe Analytics 🥼 retweeted
I guess my point is that the less expensive labs are going to get more expensive Also there is an opportunity cost you are missing by not being able to sell product as your wait on testing
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3-5 day turnaround is solid
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Replying to @blankpeptides
heads up - while investigating another shop we found your freedom diagnostics COAs being reused with the client name changed to theirs and their product photo swapped in. the lab's search code still starts with "Blan" which is how it was caught. full writeup: peptigrity.com/discussions/h…
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Updated our LIMS so USP <85> Bacterial Endotoxin reports in EU/vial instead of EU/ml going forward Just had to build in the calculation for the initial volume 🤓
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Created a personal profile to move some of my unhinged rants there instead of on our business X account. Follow @JoshInProgress if interested
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This is a summary of the the framework for impurities per ICH Q3: Reporting threshold: typically 0.05–0.1% for peptides (lower than small molecules’ 0.05% at low dose, but this varies by dose band) Identification threshold: where you must structurally characterize the impurity, typically in the 0.1–0.5% range depending on max daily dose Qualification threshold: where you need toxicological qualification (safety data, not just identity), often 0.5–1.0% for lower-dose peptides, tighter for high-dose/chronic products Individual specified impurities are usually held to tighter individual limits (often 0.5-1.0% each) while total impurities get a looser umbrella limit (often 2-5%, sometimes higher depending on the peptide’s synthetic complexity. Longer peptides accumulate more truncation/deletion species and can justify higher total impurity allowances if each is qualified).
Who decided >99.5% is the specification for purity? Bold, considering no one knows: 1. The entire process impurity / degradation profile for any of the peptides. Really an impossible ask since they are all coming from different synthesis processes with their own unique impurities. 2. That any single HPLC method is capturing all of said impurities and degradation products today. Without those two things, setting a spec is shooting in the dark based on incomplete data. “Well this lab always gets 99.9%, so it’s possible.” It’s also possible that their method is trash and sees nothing, and so you’ve set a spec when, if analyzed per 1 & 2 above, 100% of the market will fail. It’s an unrealistic spec that harms researchers by limiting access to affordable peptides and drives testing to labs with the worst methods.
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The lab giving you the lowest purity result has the best method for purity on that peptide. The lab giving you the highest purity result has the worse method for purity on that peptide. Applies if two, four, or six labs have a higher purity result - all have worse methods.
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