At it’s core, purity should detect the peptide and closely related degradation products
We do heat degradation since that’s the most likely cause for degradation, but throw in acid/base if the peptide is pretty resistant to heat
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Next, it might catch an excipient (filler) or unknown compound by chance. We see this randomly - we’ve found phenol and m-creosol as preservatives.
Why by chance? The methods weren’t developed for these compounds - so it’s pure luck.
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The lab giving you the lowest purity result has the best method for purity on that peptide.
The lab giving you the highest purity result has the worse method for purity on that peptide.
Applies if two, four, or six labs have a higher purity result - all have worse methods.
Aug 28, 2026 · 11:19 AM UTC
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If you were shocked that 99.8% purity does not mean there is only 0.2% other stuff, learn more:
trustpointeanalytics.com/blo…
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