An interdisciplinary international journal of the American Cancer Society. Editor-in-Chief: Suresh S. Ramalingam, MD (@RamalingamMD)

Atlanta, Georgia, USA
Just released! The Annual Report to the Nation on the Status of Cancer shows that from 2019-2023, overall cancer death rates decreased largely due to fewer deaths from lung cancer. See trends in new cancer cases and deaths: acsjournals.onlinelibrary.wi… #CancerAnnualReport @OncoAlert
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New #OpenAccess review article 🔓 Progression-free survival and objective response rate as a surrogate end point for overall survival in metastatic #RenalCellCarcinoma: A systematic review and meta-analysis acsjournals.onlinelibrary.wi… @OncoAlert
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New #OpenAccess study by @HiraSMian et al suggests that ciltacabtagene autoleucel remains effective in frail RRMM, but frailty is associated with reduced survival & increased toxicity, supporting tailored CAR-T strategies. acsjournals.onlinelibrary.wi… @OncoAlert @MeeraMohanMD #MMSM
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So great to see coverage of this year's #CancerAnnualReport featuring 21st century progress on #LungCancer in the @OncoAlert newsletter! Read the report led by @CDCgov @theNCI @AmericanCancer @NAACCR here: acsjournals.onlinelibrary.wi…
This week’s OncoAlert 🚨 Newsletter is OUT ^ packed with the latest in Oncology Don’t miss the latest updates—register to get it 👉 buff.ly/N5gYtAc Pinging: @OncoAlert @Uromigos @matteolambe @aftimosp @E_de_Azambuja @DrSGraff @ErikaHamilton9 @double_whammied @maryam_lustberg @raalbany @hoperugo @stolaney1 @LoiSher @JaniceTNBCmets @montypal @DrDanielHeng @apolo_andrea @DrChoueiri @PGrivasMDPhD @TiansterZhang @neerajaiims @amerseburger @sonpavde @drenriquegrande @tompowles1 @cdanicas @nataliagandur @realbowtiedoc @Onco_Cifu88 @scocmem @FernandoOnco @ElisaAgostinett @to_be_elizabeth @Erman_Akkus @MarioBalsaMD @DrMirallas @GIMedOnc @UOzkerim @DrRishabhOnco @PaulJiL @DaisukeKotani @DraMartinezLago @p_ciracimd @BenWestphalen @CentralParkWMD @graokane @amandaNizamMD @DrVilmaPBarcia 1/ The OncoAlert Newsletter | Sept 18–24 For colleagues, by colleagues. This week's top findings 🧵 [LINK] 2/ SPOTLIGHT: ABC8 consensus guidelines for advanced breast cancer are out. They revise endocrine sensitivity/resistance definitions and add new guidance on AI, biomarkers, IBC and brain imaging. @[ABC handle] 3/ PART trial (BJUI): ~306 patients in a UK RCT comparing HIFU/IRE partial ablation vs radical treatment in intermediate-risk prostate cancer. Can we keep cancer control and protect function? 4/ I3LUNG (Nat Med): explainable AI for choosing IO in NSCLC. AUC up to 0.77 in 2,396 patients, beating PD-L1, ECOG, NLR, LDH and LIPI. Prospective validation is next. 5/ PANXEON (Nat Med): miRNA + CA19-9 blood test reached 86.8% sensitivity for stage I–II PDAC in 1,785 individuals. Promising for early detection. 6/ Also in this edition: UTUC molecular staging with utDNA + ctDNA (OR 8.5), IOTA two-step for adnexal masses, and testosterone recovery after ADT. Full newsletter:
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Results from a new study from researchers in France indicate that salvage regimen should be proposed in this context, allowing 50% of patients with Ph– B-cell acute lymphoblastic leukemia to achieve CR2 and have better survival. acsjournals.onlinelibrary.wi… @OncoAlert #leusm
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New editorial: Toward a globally integrated histologic risk classification of pretreated Wilms tumor Editorial: acsjournals.onlinelibrary.wi… Accompanying article: acsjournals.onlinelibrary.wi… @OncoAlert #WilmsTumor #PedOnc
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Check out @PedAYAJournal's first original research article! 💜 @OncoAlert @ACSNews @billdahutmd @WileyHealth #AYACSM #PedCSM #PedOnc #AYACancer
🧭 What support do young adults with #BreastCancer need, and when? Our first original research article maps 87 care priorities across treatment, from early financial help to later mental health needs. 🔗: acsjournals.onlinelibrary.wi… #AYACancer @OncoAlert @smyersMD @OSUCCC_James
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The U.S. has made substantial progress against lung cancer in the 21st century. What’s driving it, and how can that progress continue? @AhJemal of @AmericanCancer discusses findings from the latest #CancerAnnualReport on #CancerSpeak. 🎧 cancerspeak.podbean.com/e/an… @OncoAlert
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Just published 📣 An @AmericanCancer consensus workshop recommends new trial measurements to fast-track initial evaluation of multi-cancer early detection tests. Read the #OpenAccess report: acsjournals.onlinelibrary.wi… @OncoAlert @ACSNews @billdahutmd #MCED #CancerDetection
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The latest #CancerAnnualReport is out. Now, hear from the experts behind it. 🎙️ In a new #CancerSpeak episode, authors discuss the latest U.S. cancer trends and 21st century progress against lung cancer. 🎧 Listen: cancerspeak.podbean.com/e/an… @OncoAlert @ACSNews
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Can vitamin C improve outcomes in people with pre-cancer blood disorders? Phase 2 trial results warrant further study in a phase 3 trial: acsjournals.onlinelibrary.wi… @OncoAlert @VAInstitute
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New & #OpenAccess from @UTMDAnderson researchers: Although short-lived responses to leukemia-directed therapy are common, long-term survival in most patients with Li-Fraumeni syndrome developing myeloid neoplasms are poor. 🔗: acsjournals.onlinelibrary.wi… @OncoAlert #LeuSM
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Impact of post-chemotherapy classification on outcomes in stage III and IV unilateral favorable histology Wilms tumor: Pooled data from Children’s Oncology Group AREN0532, AREN0533, and AREN03B2 studies acsjournals.onlinelibrary.wi… @OncoAlert @CHOPCancerCntr
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Conclusions from this new study indicate that the SENECA index is a practical instrument for prognostic stratification of patients with biliary tract cancer receiving chemoimmunotherapy. Learn more: acsjournals.onlinelibrary.wi… @OncoAlert
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The @FDA has granted full approval to the heterobifunctional protein degrader vepdegestrant for certain adults with ER–positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer. Our latest #CancerScope tells more: acsjournals.onlinelibrary.wi… @OncoAlert
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A 12-week course of TRT in men treated with radical prostatectomy for low-grade prostate cancer and hypogonadism significantly improved sexual and physical functions according to the results of a recently published study. See our coverage: acsjournals.onlinelibrary.wi… @OncoAlert
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New in #CancerScope 📗🔎 Radiotherapy may benefit select patients with #KidneyCancer, but more trials are still needed to determine its role in relation to standard treatments. Read our coverage of the latest findings: acsjournals.onlinelibrary.wi… @OncoAlert #KCSM
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New! Timing matters: Impact of covalent BTK inhibitor dose modifications on outcomes in chronic lymphocytic leukemia/small lymphocytic leukemia—A 7-year real-world study acsjournals.onlinelibrary.wi… @OncoAlert
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New #OpenAccess review on the clinical management of clonal hematopoiesis, including approaches to diagnosis, tools for risk stratification, and strategies for surveillance and comorbidity mitigation: acsjournals.onlinelibrary.wi… @garciamanero @UTMDAnderson @OncoAlert
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Is autologous cellular therapy reaching a turning point in #melanoma and solid tumors? Explore the year's top advances, from FDA-approved TIL therapy to next-generation cellular approaches. 🔗: acsjournals.onlinelibrary.wi… @OncoAlert @kimberlyloomd @DrBetofMDPhD
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