Impressive work from @JShendure & co. reconstructing an E13.5 lineage tree with DNA Typewriter. A great complement to our PEtracer lineage atlas spanning E7.5-E10.0 (mela.wi.mit.edu). Excited to see what an integrated analysis of these datasets reveals!
Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote
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Jul 31, 2026 · 10:28 PM UTC
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