Jun Liu Lab@JunLiuLab

Cryo-electron Tomography @YaleMed Department of Microbial Pathogenesis Microbial Sciences Institute #cryoEM #cryoET

 New Haven, CT
medicine.yale.edu/lab/jun_li…
Joined June 2018
61 Photos and videos
Postdoctoral Positions @JunLiuLab @Yale #CryoET #CryoEM #postdocs #postdocposition #sciencejobs m.yale.edu/qzr7
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nature.com/articles/s41467-0… @guowangbiao @YueJianUSTC @cryoHuaxinYu @YaleMicroPath @YaleMed #insitu #cryoEM #Vibriocholerae #flagella #motility

Near-atomic in situ architecture and membrane-coupled dynamics of the Vibrio cholerae sheathed...

Nature Communications - The sheathed flagellum of the pathogen Vibrio cholerae supports bacterial motility, environmental survival, and persistent colonization of the human gut. Here, the authors...

nature.com
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Jun Liu Lab retweeted
YaleMicroPath@YaleMicroPath
Aug 3
Come be our colleague! @YaleMicroPath offering Assistant Professor #facultyposition in #pathogenesis of viral/bacterial/parasitic infections, pathogen-host interactions, #microbes in health and disease: apply.interfolio.com/189968. Q&A webinar 8/18. medicine.yale.edu/micropath/
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westcampus.yale.edu/news/202…

‘Atomic zoom’ brings gum disease bacteria into sharp focus

The lab of Jun Liu has cracked a 50 year old puzzle to reveal the precise shape and structure of the bacterium responsible for gum disease

westcampus.yale.edu
Jun Liu Lab@JunLiuLab
Jun 25
nature.com/articles/s41467-0… @guowangbiao Jiaqi Clem Wang Jack Botting @YaleMicroPath @YaleMed et al #cryoET #cryoEM #spirochetes
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nature.com/articles/s41467-0… @guowangbiao Jiaqi Clem Wang Jack Botting @YaleMicroPath @YaleMed et al #cryoET #cryoEM #spirochetes

Asymmetric architecture and adaptation of Treponema flagella

Nature Communications - Here, the authors present cryo-EM structures of the intact asymmetric core–sheath supercoiled flagellar filament in Treponema denticola, a major periodontal pathogen,...

nature.com
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Congratulations to @JunLiuLab @YaleMicroPath researcher @guowangbiao for receiving the poster award at the 11th Annual @Yale Biophysics and Structural Biology Symposium!
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Using in-situ single particle cryo EM, the Liu lab has characterized the asymmetrical flagellar sheath of Treponema denticola biorxiv.org/content/10.64898…
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Structural insights into the assembly and evolution of a complex bacterial flagellar motor nature.com/articles/s41564-0… @YaleMed @YaleMicroPath In collaboration with Beile Gao (CAS), Xiang Gao (Shandong University), Matt Baker (UNSW), and Maria Lara-Tejero (Yale University)
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Jun Liu Lab retweeted
YaleMicroPath@YaleMicroPath
5 Dec 2025
New View of Cholera ‘Tail’ Could Inform Treatment m.yale.edu/dddn @guowangbiao @JunLiuLab @NatureMicrobiol

New View of Cholera ‘Tail’ Could Inform Treatment

Researchers took a detailed image of the cholera bacteria’s flagella, which could explain how they move so quickly and offer new routes for treatment.

medicine.yale.edu
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Congratulations to the Mougous Lab, recent arrivals at Yale’s Microbial Sciences Institute @YaleMicroPath, on their discovery of “umbrella toxins” cell.com/cell/fulltext/S0092… @CellPressNews @YaleMed
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Jun Liu Lab retweeted
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@guowangbiao
3 Dec 2025
How does the sheathed flagellar motor rotate while adapting to fluctuations of the outer membrane? What happens after the motor is shed? Here is the answer: nitter.net/JunLiuLab/status/19962… biorxiv.org/content/10.64898…
Jun Liu Lab@JunLiuLab
3 Dec 2025
#preprint from @JunLiuLab #postdoc @guowangbiao and @YueJianUSTC @YaleMed #Vibriocholerae #flagellum biorxiv.org/content/10.64898…
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Jun Liu Lab retweeted
Andy Goodman@Goodman_lab
3 Dec 2025
An unexpected mechanism for population heterogeneity in the gut microbiome, led by @YaleMicroPath grad student @annapaigez and Ran Mo. cell.com/cell-host-microbe/f…

A commensal bacterium secretes effector proteins to establish population heterogeneity in the gut

Zagieboylo and colleagues demonstrate that the human commensal Bacteroides thetaiotaomicron secretes two self-targeting proteins that induce heterogeneity within its own population. Differential...

cell.com
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#preprint from @JunLiuLab #postdoc @guowangbiao and @YueJianUSTC @YaleMed #Vibriocholerae #flagellum biorxiv.org/content/10.64898…
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linkedin.com/posts/yale-west…

Yale researchers uncover cholera's swimming mechanism | Yale West Campus posted on the topic |...

Cholera has caused numerous global pandemics, with the WHO estimating as many as 143,000 deaths from the illness each year.   The lab of Jun Liu, Yale Microbial Sciences Institute, has uncovered the...

linkedin.com
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Jun Liu Lab@JunLiuLab
17 Nov 2025
Congratulations to #postdoc @cryoHuaxinYu @JunLiuLab @YaleMed for insightful findings @ScienceAdvances #cryoEM #cryoET #Lambdaphage Structural basis of bacteriophage Ur-lambda infection initiation science.org/doi/10.1126/scia…
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Congratulations to #postdoc @cryoHuaxinYu @JunLiuLab @YaleMed for insightful findings @ScienceAdvances #cryoEM #cryoET #Lambdaphage Structural basis of bacteriophage Ur-lambda infection initiation science.org/doi/10.1126/scia…

Structural basis of bacteriophage Ur-lambda infection initiation

In situ structures reveal molecular insights into infection initiation of bacteriophage Ur-lambda.

science.org
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Beautiful work using #insitu #cryoEM #SingleParticleAnalysis from @guowangbiao @YaleMicroPath in @NatureMicrobiol nature.com/articles/s41564-0…
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Now in 3D: Yale scientists catch Legionnaires' disease ‘in the act’. bit.ly/nowin3D @Yale @PNASNews @JunLiuLab @YaleMicroPath @Goodman_lab

Now in 3D: Yale scientists catch Legionnaires' disease ‘in the act’

The Yale labs of Craig Roy and Jun Liu have harnessed the power of cryo-EM to solve a 30-year mystery of how the Legionella bacteria works

westcampus.yale.edu
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Great work from @YueJianUSTC @YaleMicroPath @YaleMed in @PNASNews #Legionella #T4SS pnas.org/doi/10.1073/pnas.25…

In situ structures of the Legionella Dot/Icm T4SS identify the DotA–IcmX complex as the gatekeeper...

The Dot/Icm machine of Legionella pneumophila is among the most versatile type IV secretion systems (T4SSs), capable of translocating more than 330...

pnas.org
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The Stavroula Hatzios lab has revealed how different gut bacteria feed on a dietary antioxidant found in mushrooms – and a potential target pathway for colorectal cancer therapeutics bit.ly/mushroommolecule
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Happy to share @JunLiuLab @YaleMed #postdoc Samira Heydari’s chapter on #cryoET @ElsevierConnect shop.elsevier.com/books/cryo…

Cryo-electron Tomography

Cryo-Electron Tomography: A Journey from Sample Preparation to Data Mining providing a holistic overview of this rapidly advancing field and equipping researchers with the knowledge and tools...

shop.elsevier.com
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