Chemical Biology lab @HarvardMed and @DanaFarber. We use a multidisciplinary approach to study biological roles of epigenetic proteins & transcription factors.
Boston, MA
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What a remarkable scientist, compassionate physician and inspiring innovator. @FilbinMariella congratulations on your outstanding work.
@FilbinMariella, MD, PhD, studies childhood brain cancers by directly studying the tumors of the patients she treats. By understanding the biology of these cancers, she is discovering new strategies to treat them. Learn more about her work here: bit.ly/4wTe697
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Our support page set up now @AlexsLemonade @TheVFoundation @StBaldricks @bcutd_research @EpendymomaRF @IronMattLarson @curingcancer.
labs.dana-farber.org/qilab/s…
Your support is essential for our cancer research. Please support our cancer research.
danafarber.jimmyfund.org/sit…
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Thank you for featuring our collaborative work.
A new study from @DanaFarber reports the first potent and selective compound to target IRF4 and validates degradation of IRF4 as a potential approach to the treatment of #MultipleMyeloma.
🔎 See the abstract from Drs. @JunQiLab and @IrenemGhobrial: go.nature.com/4wq8rY0
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We also like to thank @AlexsLemonade @StBaldricks @EpendymomaRF @sontagfdn @IronMattLarson @curingcancer @sontagfdn @TheVFoundation and more... for their support and helping us build the drug discovery capability for pediatric brain tumor.
Thrilled to share our collaborative work with @FilbinMariella, now online in Neuro-Oncology! We identify HDAC2 as a tractable target for H3K27M DMG growth in vitro and in vivo. Congrats to @JunQiLab and @FilbinMariella — excited for more to come together!
academic.oup.com/neuro-oncol…
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Thrilled to share our collaborative work with @FilbinMariella, now online in Neuro-Oncology! We identify HDAC2 as a tractable target for H3K27M DMG growth in vitro and in vivo. Congrats to @JunQiLab and @FilbinMariella — excited for more to come together!
academic.oup.com/neuro-oncol…
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Our study demonstrated that IRF4 can be chemically targeted. Our approach can be further developed into novel therapy for multiple myeloma.
nature.com/articles/s41589-0…
Please support our drug discovery effort for high risk tagets @JunQiLab at @DanaFarber. danafarber.jimmyfund.org/sit…
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Our collaborative work with @IrenemGhobrial on targeting transcription factor IRF4 is now online @nchembio. It is so exciting that we discovered an IRF4 binder & a selective IRF4 degrader that can interrupt MM cell growth. Congrats @10mM_Mike & all authors rdcu.be/flcIs
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Our collaborative study with Dr. Qiong Duan on histone acetylation regulated energy storage is now published @MolMetab. We established more understanding on how "active" acetylation vs "passive" acetylation balanced each other at different states. molecularmetabolism.com/arti…
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Thank you @StBaldricks for highlight our research on studying natural compound in DMG with Prof. Movassaghi @ChemistryMIT and @FilbinMariella. Thank you so much for your support @StBaldricks
Hope is powerful. Research is lifesaving. 🙏
Your support helps fund groundbreaking discoveries for children battling cancer.
Read how it’s making a difference in our latest edition of Research Outcomes: ow.ly/sNel50YhTUk
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With better understanding of proteosome machinery, hopefully, we can come up more and more cool idea to utilize the system for novel therapy development.
New research in @angew_chem by @DanaFarber’s @JunQiLab reveals a novel chemical biology approach to achieving selective targeted protein degradation using proteosome cap region proteins directly in addition to the current PROTAC strategy, which could aid in developing therapies and cancer drugs.
➡️ bit.ly/4rbilu9
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It was such a fun day to visit @PennMedicine and talk about science with @junwei_s @LilingWanLab and present our science. Thank you for having me.
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Our work using cap region proteins of proteosome to directly induce targeted protein degradation is now published online @angew_chem. Congratulations to all the authors on bringing this to the finish line. Thanks @BloodCancerUtd for supporting our work.
doi.org/10.1002/anie.2025200…
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We would like to thank the support from @EpendymomaRF, @curingkidsckc and @StBaldricks that allow us to build our biology capability to explore novel therapeutic options for pediatric brain cancer.
Our collaborative work with Prof. Mo Movassaghi at @chemistryMIT and @FilbinMariella is now online @acsJACS @ACSPublications. Thrilled to work as chemical biology part to explore therapeutic potential of these awesome nature compounds from Mo's lab. pubs.acs.org/doi/10.1021/jac…
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I am thrilled to work and publish together with my postdoc PI, Prof. Mo Movassaghi @ChemistryMIT to bring their sophisticated chemistry to potential therapy development. I am excited to keep learning from Mo and @FilbinMariella. Pic from: news.mit.edu
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Our collaborative work with Prof. Mo Movassaghi at @chemistryMIT and @FilbinMariella is now online @acsJACS @ACSPublications. Thrilled to work as chemical biology part to explore therapeutic potential of these awesome nature compounds from Mo's lab. pubs.acs.org/doi/10.1021/jac…
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This is absolutely fun!!! @LabSethi cannot wait to do more together. To create more and better understanding in cancers and find potential novel therapy together. @AGA_Gastro
Can we have a biotinylated and inactive version of the HDAC1/2 inhibitor? How do you do Chem-seq, Jun? In the end, we were able to follow our observations and publish these findings thanks to collaborative science fostered by @DanaFarber @DanaFarberNews
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It is so exciting to see the final version of our collaborative work with @LabSethi. We found that blocking HDAC1/2 pushes CRC cells out of a stem-like state and into differentiation. We will work tother more to find novel therapeutic options for CRC. authors.elsevier.com/c/1m7oK…
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It is so exciting to see our collaborative work with @Nilay_Sethi is now available online. My team and I are always eager to learn more about novel therapy development for CRC together with Nilay and his wonderful team!!!
Proof-of-concept: Epigenetic reprogramming could one day be a new therapeutic path in colorectal cancer. @Nilay_Sethi explains how histone acetylation shapes CRC cell fate in this @AGA_Gastro study: bit.ly/46gS7z1
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It is awesome to have JQ-WON team to build a boat and get first place in the boat building competition at @DFCI_ChemBio retreat!!!! Awesome design, decoration, ride, and teamwork!
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It is so great to have @LilingWanLab to visit us and give a great seminar.
Had a great time visiting Dana-Farber Cancer Institute and sharing our work on chromatin mechanisms in cancer! Huge thanks to @JunQiLab for the invitation and generous hosting. So much fun reconnecting with mentor & old friends, making new ones, & a full day of amazing science!
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