Junwei Shi@junwei_s

Associate Professor at UPenn

 Philadelphia, PA
shipennlab.wixsite.com/shi-l…
Joined March 2013
5 Photos and videos
One more thing. Another work led by the dedicated and talented scientists @DiqiuR and Shangshang Wang, stemming from our long-standing collaboration with Rahul Kohli and @andyjminn’s labs at Penn. nature.com/articles/s41587-0…
1
8
53
6,162
Junwei Shi retweeted
E. John Wherry@EJohnWherry
May 18
Very excited to get this new work by Shin Ngiow up on #bioRxiv. We may be blocking PD-1 too long causing detrimental effects on Tpex cells. A drug holiday approach may be beneficial. Also some cool new Tpex biology here. #immunopharmacology biorxiv.org/content/10.64898…
3
25
112
10,233
Inducible, split base editors for in vivo cancer functional genomics go.nature.com/4tfu1xi
1
19
108
9,841
One more thing. Another work led by the dedicated and talented scientists @DiqiuR and Shangshang Wang, stemming from our long-standing collaboration with Rahul Kohli and @andyjminn’s labs at Penn. nature.com/articles/s41587-0…
1
8
53
6,162
more replies
A high-resolution tiling base editing mutagenesis screen targeting Adar1, an adenosine deaminase associated with tumor immunity, identified both loss-of-function and gain-of-function alleles.
1
1
182
Our improved, inducible base editing system (seBE) provides controllable and robust genome editing to systematically identify functionally relevant key residues for cancer functional genomics.
124
Have been missing twitter. Excited to share our new study. This was a close collaboration with Kathrin Bernt's and @KaiTanLab1 labs, led by the talented and unstoppable @TomZhendong and Sixiang Yu cell.com/molecular-cell/full…

CRISPR-based functional genomics for dissecting therapeutic dependency in primary acute myeloid...

Direct CRISPR functional genomics in primary patient samples holds promise for therapeutic target validation and discovery. Cao et al. develop an optimized CRISPR platform for genetic screening in...

cell.com
4
4
53
5,092
more replies
CRISPR knockout screens reveal both shared and distinct AML dependencies in primary samples. CRISPRi screens identify essential cis-regulatory elements in PDXs. We further used Perturb-seq to dissect regulatory networks and cellular heterogeneity in primary AML cells.
1
232
This robust and general CRISPR-based functional genomics approach in primary AML patient samples opens up new opportunities to prioritize/identify therapeutic targets and understand resistance mechanisms in AML.
148
Junwei Shi retweeted
Penn Medicine CSO@PennMedCSO
Mar 20
ft. @TomZhendong, S. Yu, Y. Liu, L. Liu, @junwei_s (@Penn_CBIO/ @PennEpiInst), @jackiejpeng (@UPennGCB), D. Barrett, J. Sussman, C. Chen, A. Thadi, F. Alikarami, J. Xu, @cdktmw, @kathrinbernt (@CHOP_Research) & Martin Carroll (@PennCancer) @CAMBUpenn cell.com/molecular-cell/full…
7
8
577
Healthy blood cells can live without ARHGAP45—but acute myeloid leukemia cells can’t. 🩸 Junwei Shi, PhD, Associate Professor of Cancer Biology (@junwei_s) and team show a CAR T + CDC42 inhibition strategy could target AML with minimal side effects. bit.ly/45OyXQu
Healthy blood cells and cancer cells illustration.

ALT Healthy blood cells and cancer cells illustration.

2
4
1,236
Systematic evaluation of GAPs and GEFs identifies a targetable dependency for hematopoietic malignancies ft. Yuqiao Liu & @junwei_s (@Penn_CBIO) @CD_AACR aacrjournals.org/cancerdisco…
3
7
849
Excited to share our new study, in close collaboration with @AbdelWahablab and @DaniyanMd led by the exceptionally talented scientists @PuZhang09980432 and @TomZhendong doi.org/10.1158/2159-8290.CD…

Systematic Evaluation of GAPs and GEFs Identifies a Targetable Dependency for Hematopoietic...

Unbiased genetic screens identify the minor antigen ARHGAP45 as a selective dependency across blood cancers that spares normal blood cells and can be targeted by TCR-CAR T cells in combination with...

aacrjournals.org
4
3
27
2,117
more replies
Even more exciting: CDC42 inhibition not only synergizes with ARHGAP45 loss intrinsically in leukemia cells, but also enhances TCR-CAR T cell function. A dual strategy to target cancer cells and augment immune responses.
1
2
213
This has truly been a fantastic collaboration that I can only dream of @AbdelWahablab, @DaniyanMd, @TomZhendong, and @PuZhang09980432
1
1
202
Replying to @AbdelWahablab @DaniyanMd @PuZhang09980432 @TomZhendong @ChrisVakoc
This has truly been a fantastic collaboration that I can only dream of @AbdelWahablab, @DaniyanMd, @TomZhendong, and @PuZhang09980432
115
Load more