Kirill Martemyanov Lab retweeted
What do you get when #NationalProteinDay and #NationalPokémonDay meet? Pikachurin. ⚡
A 2023 @scisignal study solved the structure of this extracellular protein that plays an essential role in vision.
In the retina, light is perceived by photoreceptor cells that transmit signals to neurons called bipolar cells, which in turn relay the signal to the retinal ganglion cells that form the optic nerve. The activation of bipolar cells by photoreceptor cells depends on the precise positioning of multiprotein complexes on the surfaces of both cell types.
Pikachurin is an extracellular matrix protein that bridges these complexes by making contacts with the membrane protein dystroglycan on the photoreceptor cell and the receptor GPR179 on the bipolar cell, thus ensuring that photoreceptor cells are properly aligned with the bipolar cells.
Learn more: scim.ag/41dTWIP
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From the one and only Jacob Rowe. An Editorial Pick which highlights top papers at the greatest @jbiolchem ! Check it out- this is molecular engineering at its best.
PIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein Regulators - Journal of Biological Chemistry jbc.org/article/S0021-9258%2…
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Awesome work!!!
New in JBC press: "Pathogenic variants in KCTD1 disrupt cAMP signaling and cellular communication associated with developmental pathways."
Learn more:
jbc.org/article/S0021-9258(2…
#jbiolchem
ALT Figure 1. Cellular stability of pathogenic BTB domain mutations in KCTD1.
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We found that endogenous ligand for GPR139 is opioid peptide dynorphin. With this, GPR139 may not be an orphan any more but the 5th opioid receptor. Heavy lift by talented Xiaona Li with great thanks to all who contributed!
nature.com/articles/s41467-0…
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Wow!!!
Excited to present our preprint on the structure-function relationship of anaphylatoxin complement receptors. A casual number of 19 structures deciphering ligand recognition mechanisms, G protein/arrestin and species specific signaling. Check it out! biorxiv.org/content/biorxiv/…
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We have innovated design of templates for CRISPR/Cas9 editing which allows efficient introduction of epitope tags in vivo. It is a simple hack which we hope to be broadly useful. Work by talented graduate student Chuanping Zhao.
nature.com/articles/s41467-0…
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Kirill Martemyanov Lab retweeted
The ON/OFF dichotomy is fundamental to visual processing. In a new study led by Flori Soto, we identify a conserved molecular mechanism establishing the OFF pathway. rdcu.be/eikoa
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Our latest on GPCR function in the brain. We report that glutamate receptor mGlu4 needs to be properly positioned at synapses of cholinergic interneurons in NAc by cell adhesion molecule ELFN1 to regulate opioid reward.
pnas.org/doi/epub/10.1073/pn…
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A popular FDA-approved drug to treat hypertension, hydralazine works, at least in part, by modulating RGS proteins! Honored to be a part of a collaborative team led by @MegaMatthewsLab!
biorxiv.org/content/10.1101/…
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Excited to share our latest on ELFN1 mechanisms, a dysfunction of which leads to a devastating neurodevelopmental disorder. Swan song of @GPCRHenry. #GPCR , #Elfn1, @jbiolchem
sciencedirect.com/science/ar…
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Kirill Martemyanov Lab retweeted
Happy to introduce DeFrND: designer peptide scaffolds to enable detergent-free reconstitution of membrane proteins with native lipids into nanodiscs for biochemical and structural studies. Let me know if you would like to try it.
biorxiv.org/content/10.1101/…
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An amazing paper- a treat to read! Can't be more proud of former postdocs doing awesome science! Go Brian Muntean!
pnas.org/doi/10.1073/pnas.24…
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Kirill Martemyanov Lab retweeted
As shown recently a single point mutation in G protein alpha subunit yields a stable complex without the use of stabilizing nanobodies!
nature.com/articles/s41467-0…
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Soluble GPCRs! Check it out! Congrats @befcorreia !
nature.com/articles/s41586-0…
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This is a must read masterclass in sensory circuit dissection and really cool behavioral adaptation!
In a new study led by @mike_fitz23, we describe a pupillary contrast response in mice and humans, which senses temporal contrast to enhance spatial contrast in the retinal image and increase visual acuity. We decipher the underlying neural mechanisms. bit.ly/3w8ieIV
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Frizzled receptors are so cool. Consolidated model of GPCR realm with scaffolding signalosome.
Check out our new review in TiPS "Frizzleds act as dynamic pharmacological entities" written with the postdocs in the team: @GraetzLukas @PKozielewicz @MagdalenaScharf @JanVo12 and twitterless Julien Bous.
authors.elsevier.com/sd/arti…
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