We uncover how cells sense, communicate, and exchange material, with a focus on pH sensing, intercellular communication, and the dark proteome.
Miami
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IsomLab retweeted
Brain cancers take advantage of neural circuit activity. Re-purposing an anti-seizure med called levetiracetam disrupts an important neuron-cancer interaction in #DMG #DIPG, slowing growth and extending survival in mice and retrospective patient data.
nature.com/articles/s41591-0…
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IsomLab retweeted
Happy to share our preprint: "A Unified 3D Generative Model for Synthesizable Structure-Based Drug Design". Highlights, preprint, and code below: 🧵1/10
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IsomLab retweeted
67 years ago today, ‘Take Five’ by Dave Brubeck Quartet was released as a single.
It went on to become the best-selling jazz single of the 20th century.
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BindCraft2 from the @MartinPacesa lab is here and available now on Ariax!
We called BindCraft a “DeepSeek moment” in protein design. BC2 builds on that proven foundation with major speed improvements and a much broader range of therapeutic formats.
ariax.bio/resources/bindcraf…
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Snuck onto the cover of Nature. Not a bad place for a “superdark” protein to end up. Very grateful. Much deserved Kyutae Lee, Sam Taylor, PhD, Jennifer Arcuri, Ph.D., Shraddha ChandThakuri, Bruno Colon, Jacinda Pujols, and others.
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That’s how we found a potentially very important human protein hiding in plain sight in our bodies.
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Thank you, Nil and @m_madan_babu, for your cool commentary on our recent Nature paper. Very well done!
The paper: nature.com/articles/s41586-0…
The commentary: ‘Superdark’ protein looks like a G-protein-coupled receptor — but shows unconventional behaviour nature.com/articles/d41586-0…
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Out online today in @Nature. The known protein universe holds hundreds of millions of members, yet most remain unexplored, a vast biological darkness that may hold important clues to human health and disease. We went looking in it.
doi.org/10.1038/s41586-026-1…
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And the people in those labs: Chenzhou Wu, Sebastian Thompson-Ceccato, Qiang Wang, Tatiana Slepak, Jonathan Mitchell, Alexandra Carbone, and Dazhi Wang. High-performance computing by Warner Baringer and Elvis Maradzike of @UMIDSC.
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Supported by an NIH R35 award from @NIGMS, @SylvesterCancer, and the @Pap_Corps, through my endowed chair. Thanks also to Steven Dwoskin, whose recent gift supports what comes next.
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7th MCP Retreat ✔️
“Colab in the Cays” | Florida Keys
53 talks. 15+ labs. Every participant presenting.
Two days of deep science, new connections, and serious inspiration.
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Our department is doing truly cutting-edge work—and becoming more interconnected than ever. Events like this push both individual and team science forward.
Huge thanks to the organizers: @danIsomLab, Jennifer Arcuri, and @BurnsteinKerry. Already excited for the next one. 🌴🧬
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