We uncover how cells sense, communicate, and exchange material, with a focus on pH sensing, intercellular communication, and the dark proteome.
Miami
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Finding candidates is relatively straightforward, with or without Claude. Extensive experimental validation and rigorous peer review are the hard parts. For context, see Fanzor, Cas13an, and our TM184C work:
doi.org/10.1038/s41586-023-0…
doi.org/10.1126/science.adq0…
doi.org/10.1038/s41586-026-1…
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Finding candidates is relatively straightforward, with or without Claude. Extensive experimental validation and rigorous peer review are the hard parts. For context, see Fanzor, Cas13an, and our TM184C work:
doi.org/10.1038/s41586-023-0…
doi.org/10.1126/science.adq0…
doi.org/10.1038/s41586-026-1…
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Snuck onto the cover of Nature. Not a bad place for a “superdark” protein to end up. Very grateful. Much deserved Kyutae Lee, Sam Taylor, PhD, Jennifer Arcuri, Ph.D., Shraddha ChandThakuri, Bruno Colon, Jacinda Pujols, and others.
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Out online today in @Nature. The known protein universe holds hundreds of millions of members, yet most remain unexplored, a vast biological darkness that may hold important clues to human health and disease. We went looking in it.
doi.org/10.1038/s41586-026-1…
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PIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein Regulators - Journal of Biological Chemistry jbc.org/article/S0021-9258%2…
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Thank you for the delicious birthday cake, Shraddha (the DAPI staining on the cells was spot on!), and gifts from Jen, Jacinda, Sam, and Kyutae❤️ Who doesn't love purple owls?
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@MayorDaniella, this resilient elderly woman struggling to make it down the stairs because the elevator (visible) and down escalator at Dadeland South are broken. @FixMetroMDT @iheartmiami305
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Well said.
Cryo-EM structure of an activated GPR4–Gs signaling complex
nature.com/articles/s41467-0…
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An incredible night, incredible honor, and incredibly impactful team: @Pap_Corps, @SylvesterCancer, and @danIsomLab.
Incredible endowed chair ceremony for @danIsomLab last night! Thank you @Pap_Corps for bestowing this honor upon @SylvesterCancer @danIsomLab. @DrSDNimer, Kerry Burnstein & team sure know how to recruit best rschers in the country!! #Miami #toptalent #cures
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Yay @d_bayik! Can a Diabetes Drug and Immunotherapy Help Treat Brain Cancer? - InventUM news.med.miami.edu/can-a-dia…
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In my excitement for his visit, I forgot to get a selfie with Henrik. This will have to do 😂😂!
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Winner winner chicken dinner! Great job on the poster, Sam, about acidic TMEs and illuminating the unknown. Thanks, @SylvesterCancer, for recognizing the hard work of our talented CAB graduate students. It's always a great retreat.
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"With its help, they have been able to predict the structure of virtually all the 200 million proteins that researchers have identified." 🤔
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Our small review on using yeast synthetic biology to advance human GPCR biology and pharmacology.
tinyurl.com/2p88y72h
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