KPL ApS@KPL_ApS

At the Cutting-Edge of Protein Innovation.

 Copenhagen, Denmark
kplbio.com/
Joined September 2024
9 Photos and videos
🔬 New bioRxiv preprint: Arg-C Zero, recombinant arginyl endopeptidase with >99% cleavage efficiency, proline-adjacent cleavage, Histone and labile PTMs analysis like ADP-ribosylation and comparable proteome depth to Trypsin. doi.org/10.64898/2026.05.28.… #Proteomics #TeamMassSpec
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🇫🇮🔬 We're at #FinnProt2026 in Espoo, Finland! Our CTO @HdezRollan is presenting a poster with the latest from our R&D pipeline 👀 Stop by to get an early look at what's next from KPL! #Proteomics #MassSpectrometry #TeamMassSpec
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🚀 New #proteomics product: Trypsin/Lys-C Premium Mix With the right formulation, you can add Lys-C and Trypsin together instead of sequentially. 🧪 One tube ⏱️One incubation 📉 Best-in-class missed cleavage rates 🌱 100% recombinant kplbio.com/trypsinlysc/
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Introducing Trypsin RMS - our third product is here. Recombinant. Methylated. Sequencing-grade. The robust Trypsin #proteomics labs need, without the batch variability of animal-derived alternatives. Learn more: kplbio.com/trypsin/ #TeamMassSpec
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Trypsin is the workhorse of bottom-up proteomics. But when was it first discovered? 🤔🤔🤔 (Answer in the comments)
50% 1836
0% 1876
50% 1897
0% 1931
2 votes • Final results
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The answer is 1876. German physiologist Wilhelm Kühne discovered trypsin while working at the University of Heidelberg. He extracted it from pancreatic juice and showed it could digest proteins outside a living organism.
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The following year, Kühne coined the term "enzyme" (from Greek "en zyme", in yeast). Fun fact: many sources say "trypsin" comes from Greek for "rubbing" because Kühne ground up the pancreas. That's a myth. It actually comes from "thrýpto", meaning "I break".
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New publication alert!📢 KPL collaborates w/ @JesperOlsenLab on the first systematic comparison of LysC enzymes for proteomics published in @JProteomeRes A. lyticus LysC: >90% cleavage efficiency, >97% specificity Read more: pubs.acs.org/doi/10.1021/acs… #TeamMassSpec #proteomics

Comparative Analysis of Lysine-Specific Peptidases for Optimizing Proteomics Workflows

Abstract. This study presents a comparative analysis of three LysC endopeptidase homologues from Achromobacter lyticus (A. lyticus),Pseudomonas aeruginosa

pubs.acs.org
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Happy Holidays from KPL! 🎄 Our first full year: 2 product launches, lots of foundation building, and countless hours pushing #proteomics forward. Our commitment: high quality, high performance, competitive prices. No compromises. 2026 is looking exciting - stay tuned! ✨
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KPL ApS retweeted
Tanveer Batth@ucdmrt
26 Dec 2025
Really curious to get peoples experience with using SCIEX instruments for bottom up proteomics 🤔🤔 Remember you can post anonymously so please share the price as well ! 😅
R/Proteomics@R_Proteomics
26 Dec 2025
A user is requesting input to decide between SCIEX or Thermo for proteomic MS instrument. Time for people to shine and share their experience. teddit.net/r/proteomics/… #Proteomics #Teammassspec
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A user is requesting input to decide between SCIEX or Thermo for proteomic MS instrument. Time for people to shine and share their experience. teddit.net/r/proteomics/… #Proteomics #Teammassspec
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#proteomics choose your fighter! teddit.net/r/proteomics/s/G5…

From the proteomics community on Reddit

Explore this post and more from the proteomics community

reddit.com
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🚀 Our very own @ucdmrt & @HdezRollan will be at Nordic Conference in Mass Spectrometry & Proteomics 2025! 📅 Sept 1-3 | 📍Odense, Denmark 🔬Presenting the latest protease innovations! Posters on Sept 1 and 2! kplbio.com/kpl-aps-to-unveil… #MSP2025 #Proteomics #TeamMassSpec
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To bead or not to bead? We evaluate five plasma proteomics workflows, finding bead-based methods enhance detection but show high susceptibility to cellular contamination bias. Strategies to optimize biomarker discovery in plasma proteomics. doi.org/10.1101/2025.05.07.6…
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🚨 Check out our new study on proteomic profiling in premetastatic colorectal cancer! Accross 412 tumors, we define molecular subtypes with distinct functional landscapes and revealed CAVIN1 as novel biomarkers for relapse risk. embopress.org/doi/full/10.10…

Proteomics of colorectal tumors identifies the role of CAVIN1 in tumor relapse

Molecular Systems Biology - Colorectal cancer molecular signatures derived from omics data can be employed to stratify CRC patients and aid decisions about therapies or evaluate prognostic outcome....

link.springer.com
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Announcing a new product launch at @asmsnews 2025! What is in ReSyn Biosciences new kraft box? Let's make it a little more interesting... First person to correctly guess and post in the comments gets one for free!?!
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❄️ WINTER SALE ALERT! ❄️ Big savings on our products! Cozy deals that'll warm your heart and your wallet. 🔥 Shop now before these cool prices melt away! Find out more here: kplbio.com/product/lysc/ kplbio.com/product/arg-c/ #proteomics
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Antibodies
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I am excited to share our latest publication in Science Advances! We mapped the proteome of interstitial fluid across the leg in response to exercise, discovered immune cell derived peptide regulating muscle growth @morten_hostrup @Metabolcenter @PRI_UCPH science.org/doi/10.1126/scia…

Temporal dynamics of the interstitial fluid proteome in human skeletal muscle following exhaustive...

Exercise regulates the human skeletal muscle interstitial fluid proteome in a distinct temporal manner.

science.org
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🚨 Our #singlecell article is out! We describe the Chip-Tip label-free SCP workflow quantifying >5000 proteins in single HeLa cells. With high scalability, increased depth and throughput we can now envision large-scale LFQ-SCP biomedical studies! nature.com/articles/s41592-0…

Enhanced sensitivity and scalability with a Chip-Tip workflow enables deep single-cell proteomics

Nature Methods - Chip-Tip is a label-free quantification-based single-cell proteomics workflow for deep single-cell proteomics, which identifies over 5,000 proteins and 40,000 peptides in single...

nature.com
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