🔥 Can endoscopic #obesity therapy target both anatomy AND appetite hormones? 🧠
GFMA targets the ghrelin-producing fundus before ESG 🪡.
First-in-human sequential GFMA→ESG trial
📚tinyurl.com/3hcyhz32
#GITwitter #Endoscopy #MedEd #MedTwitter @ESGE_news @ASGEendoscopy
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📉 GFMA alone achieved 7.7% TBWL at 6 mo.
✅After ESG 🪡, TBWL reached 20.0% at 12 mo and 22.5% at 18 mo 🔥.
✅Ghrelin fell 462→255 pg/mL 🧪 at 6 mo, while nutrient tolerance dropped 57% by 18 mo 🥤.
No serious AEs 🛡️
#GITwitter #Endoscopy
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🎯 Sequential GFMA→ESG targets hormonal 🧪 + mechanical/visceroceptive pathways 🧠, with 22.5% TBWL at 18 mo 📉 and improved eating behavior 🍽️.
Promising, but this was a 10-patient, single-arm pilot 🔬.
Larger controlled trials needed 📊
#GITwitter #Endoscopy
Sep 26, 2026 · 7:17 AM UTC
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