MD, PhD, MSc, MBA at @FnMotol | Interests in #IBD, #Endoscopy, #LiverDiseases, #BariatricEndo, #AI, #3DPrinting - 3NDO.eu, #ESGE SoMe WG
Prague, Czech Republic
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🔥 Can endoscopic #obesity therapy target both anatomy AND appetite hormones? 🧠
GFMA targets the ghrelin-producing fundus before ESG 🪡.
First-in-human sequential GFMA→ESG trial
📚tinyurl.com/3hcyhz32
#GITwitter #Endoscopy #MedEd #MedTwitter @ESGE_news @ASGEendoscopy
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📉 GFMA alone achieved 7.7% TBWL at 6 mo.
✅After ESG 🪡, TBWL reached 20.0% at 12 mo and 22.5% at 18 mo 🔥.
✅Ghrelin fell 462→255 pg/mL 🧪 at 6 mo, while nutrient tolerance dropped 57% by 18 mo 🥤.
No serious AEs 🛡️
#GITwitter #Endoscopy
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🎯 Sequential GFMA→ESG targets hormonal 🧪 + mechanical/visceroceptive pathways 🧠, with 22.5% TBWL at 18 mo 📉 and improved eating behavior 🍽️.
Promising, but this was a 10-patient, single-arm pilot 🔬.
Larger controlled trials needed 📊
#GITwitter #Endoscopy
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Jan Král retweeted
Join us for joint EYE–@SFED_Endoscopie #WednesdayWebinar – Nightmare Calls: Emergency Endoscopy Cases You Must Be Ready For
📆Wed, Sep 23–19:00 (CEST)
✅us06web.zoom.us/webinar/regi…
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🔥 Is 3-year surveillance after high-risk adenoma removal necessary?
🔬 The EPoS II RCT challenges current practice! 🩺 10,799 patients randomized to 3 vs 5 years.
📊 New data from NEJM: tinyurl.com/2v3yp43t #GITwitter
#GiTwitter #MedEd #MedTwitter @NEJM @ASGEendoscopy
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📊 EPoS II:
✅5-year CRC incidence 0.77% vs 0.82% (5 vs 3 years).
✅ Noninferiority met (upper 99.12% CI: 0.68%; margin: 0.7%).
🔬 48.5% fewer colonoscopies with 5-year surveillance! 📉 CRC deaths: 3 vs 2.
#GITwitter #Endoscopy
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🎯 Could 5-year surveillance replace the 3-year interval after high-risk adenoma removal?
🔬 EPoS II supports noninferiority at 5 years. 📊 Final 10-year data are pending. 🩺
❓Time to reconsider surveillance guidelines❓
#GITwitter #Endoscopy
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Jan Král retweeted
The #ESGEDays2027 Scientific Programme & Registration Fees are now online!
📋esge2027.process.y-congress.…
🎟️esgedays.org/registration/re…
The ESGE Scientific Committee has worked hard to design a high-quality programme reflecting latest advances & best practices in GI endoscopy
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⏱️ Colorectal ESD time is hard to predict.
🔬 LEDS estimates duration preprocedure 🧮 from operator speed, lesion site/size & suspected fibrosis 🪢.
📚tinyurl.com/mt7c3w6h
#GITwitter #Endoscopy #MedEd @GIE_Journal @ESGE_news @ASGEendoscopy
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🗓️ LEDS may improve ESD scheduling, anesthesia planning 🩺 and resource allocation 📈.
Accuracy was best for long cases ⏱️, but this is a single-center expert cohort 🔬external multicenter validation is needed
#GITwitter #Endoscopy
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📊 LEDS showed R²=0.52 in derivation 🔬 and 0.48 in temporal validation 🧪.
For procedures ≥120 min, validation accuracy reached 91.8% 🎯.
Operator speed, location, lesion size 📏 and suspected fibrosis predicted ESD time
#GITwitter #Endoscopy
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🚨 STEP Young phase 3: weekly semaglutide + lifestyle reduced BMI 📉 in children aged 6–<12 with obesity.
⚠️At week 68, 40.4% fell below the obesity threshold vs 0% on placebo 🧒💉.
✅No new safety concerns 🔬.
tinyurl.com/yk9ppseh
#MedTwitter #Obesity #Pediatrics
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Jan Král retweeted
The new ESGE–PENTAX Medical Ergonomics Research Grant is now open for Applications! 🎉
€8,000 is available to support innovative research aimed at improving ergonomics & preventing musculoskeletal injuries in gastrointestinal endoscopy
Apply here: esge.com/esge-grants-and-awa…
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Jan Král retweeted
THE REAL VALUE IS IN THE DISCUSSION. Experts share perspectives, strategies and lessons from the case.
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Jan Král retweeted
At this moment we have 5.000 people watching around the world! Tune in now!!!
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Jan Král retweeted
Final preparations are underway for BELG 2026, featuring a live case directly from UT Health San Antonio!
Congratulations to the directors on an incredible line-up of cases taking place across multiple countries.
@DiogoPhd @MouraEGH @SighPichamol @MetabolicEndo
Free registration! belglive.com
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ESD keeps evolving 🔬.
The new ASGE technology review covers knives 🔪, traction 🧲, closure 🧵 and modern techniques 🩺 aimed at safer, faster en bloc resection.
❗️ Check supp. tables❗️
📚tinyurl.com/2un29mdj
#GITwitter #Endoscopy @ASGEendoscopy @ESGE_news
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Key data 📊:
✅delayed bleeding varies by site -duodenum 9.1% 🩸, stomach 3.0%, rectum 2.7%, colon 1.9%, esophagus 1.7% 🔍. ✅Overall perforation: 2.9% ⚠️.
✅Traction and defect closure may improve safety 🧵.
#GITwitter #Endoscopy
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Practice point 🩺:
✅proficiency targets include ≥90% en bloc 🎯
✅≥80% complete resection 🔬
✅ AEs <5% ⚠️ and ~9 cm²/h ⏱️
Training remains a barrier
#GITwitter #Endoscopy
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Jan Král retweeted
🚀Not an ESGE Member but keen to hear the latest news, science updates, educational opportunities, and upcoming events from the Home of Endoscopy?
📧 Subscribe to our emails and be the first to hear about it: esge.com/publications/esge-n…
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