Associate Professor in Cell Biology at UTSW, studying how organelles are shaped and organized
Dallas, TX
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New preprint from our lab! We uncover how a subset of mitophagy proteins BNIP3 + NIX are repressed and protected from turnover so that they can perform a surveillance role for mitochondrial dysfunction under basal conditions. Led by postdoc @Abhishek_Mito biorxiv.org/content/10.64898…
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New preprint from our lab! We uncover how a subset of mitophagy proteins BNIP3 + NIX are repressed and protected from turnover so that they can perform a surveillance role for mitochondrial dysfunction under basal conditions. Led by postdoc @Abhishek_Mito biorxiv.org/content/10.64898…
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With key contributions from our amazing collaborators @nieminm @KeriKozul
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Check out our highlight of the most recent example of subcellular mitochondrial specialization in @CurrentBiology. Be sure to also check out the beautiful work from David Sherwood's lab
cell.com/current-biology/ful…
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A reminder to join us at 12pm ET today!
I'm excited to host the ASBMB LRD seminar series next Thurs 4/9 at 12pm ET. Please join us for talks from @Zak_Bakes (from @Pagliarini_Lab) and Sara Wong (from @Adam_L_Hughes lab) on the intersection of mitochondria and lipid metabolism!
Register here: asbmb.org/meetings-events/lr…
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I'm excited to host the ASBMB LRD seminar series next Thurs 4/9 at 12pm ET. Please join us for talks from @Zak_Bakes (from @Pagliarini_Lab) and Sara Wong (from @Adam_L_Hughes lab) on the intersection of mitochondria and lipid metabolism!
Register here: asbmb.org/meetings-events/lr…
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Jonathan Friedman retweeted
Thrilled to share our work "Recessive PPTC7 deficiency triggers excessive mitophagy to cause a severe inborn error of metabolism with hypomyelinating leukodystrophy" - a collaborative effort documenting the first cases of PPTC7 mutations in humans. 1/n
researchsquare.com/article/r…
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Jonathan Friedman retweeted
Really thrilled to share our work on mitochondrial presequence strength @JCellBiol. We establish quantitative parameters to better define "strong" and "weak" presequences in vitro and in vivo. This work was spearheaded by the ever talented Youmian Yan, a grad student in my lab.
Youmian Yan, @IanofBristol, @nieminm et al. define quantitative parameters underlying the strength of mitochondrial-targeting presequences, and demonstrate that yeast require strong presequences to facilitate select metabolic pathways in #mitochondria. hubs.la/Q03-1x5l0
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Thrilled to announce my official promotion to associate professor with tenure at UTSW! So grateful to all the trainees in the lab for their hard work and proud of their accomplishments over the last several years. This an individual recognition but truly a team effort!
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Jonathan Friedman retweeted
Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @WashUBBSB graduate student Youmian Yan. A 🧵
biorxiv.org/content/10.1101/…
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Jonathan Friedman retweeted
Important to celebrate trainee victories: excited to have @HollyMerta's paper out in @CellReports.
We use TurboID sub-organelle proteomics to map the ER network.
We discover calmin/CLMN, an ER-to-actin tether regulating focal adhesions & cell motility.
sciencedirect.com/science/ar…
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Jonathan Friedman retweeted
If you are on UTSW campus May 16, please join us for the Lipid Metabolism & Neurodegenerative Disease mini-symposium! Many thanks to keynote speaker Dr. Hugo Bellen.
Don’t miss out on the Lipid Metabolism and Neurodegenerative Diseases 2025 Mini Symposium! Check out the agenda below for the full details ⬇️
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Reminder to join us tomorrow at 12pm ET
Be sure to mark your calendars for March 26th at 12pm ET for the @AsbmbLrd seminar series. We have two great mitochondria-focused lipid talks planned from @JasonCasler1 from Laura Lackner's lab and Kailash Venkatraman from @ibudin's lab. Register here! events.zoom.us/ev/AqPwG5k03R…
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Be sure to mark your calendars for March 26th at 12pm ET for the @AsbmbLrd seminar series. We have two great mitochondria-focused lipid talks planned from @JasonCasler1 from Laura Lackner's lab and Kailash Venkatraman from @ibudin's lab. Register here! events.zoom.us/ev/AqPwG5k03R…
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Jonathan Friedman retweeted
For #teamtomo, context is everything.
We highlight the power of #surfacemorphometrics in guiding STA and quantitatively assessing the impact of these structures on the local environment.
@benjaminbarad
Ya-Ting Chang, @nani_grotjahn et al. @scrippsresearch present a membrane-guided approach for identifying a subset of cytoplasmic #ribosomes oriented for protein import on the surface of #mitochondria in budding yeast using #cryoET hubs.la/Q039KqS80
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Some good news (and fresh science) to break things up! Our work identifying a subpopulation of compositionally unique mitochondria that localize to filopodia and promote cell migration is now online @CurrentBiology! Led by fantastic @madeleinemarlar!
cell.com/current-biology/ful…
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Jonathan Friedman retweeted
Happy to announce I am serving as Director of the Lipid Metabolism & Neurodegenerative Diseases (LMND) Program at UTSW. Our goal is to stimulate collaborations bridging lipid metabolism & neurological disease.
So proud of our lab & their cell biology adventures! #onward_science
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Jonathan Friedman retweeted
Edington et al. @labfriedman @UTSWMedCenter identify a mitochondrial inner membrane protein that marks and facilitates a subset of sites of mitochondrial fission in human cells. hubs.la/Q030B0yQ0
#Organelles #Mitochondria
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Looking for some holiday reading material? Our latest paper identifying a new player in mitochondrial fission is now out @JCellBiol! A wonderful early present to see this now online!
rupress.org/jcb/article/224/…
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As you're planning out your ASCB schedule be sure to attend the organelle-focused special interest group hosted by @nieminm and myself Mon. 12/16 at 5pm
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