Wilhelm Lab@LabWilhelm

Research group studying metabolic and dietary control of mucosal immunology - led by Dr. Christoph Wilhelm at the University of Bonn

 University of Bonn
ukbonn.de/42256BC8002AF3E7/d…
Joined December 2019
23 Photos and videos
How does obesity disrupt ILC2 function and adipose tissue hoemostasis? In our latest study, we identify acetyl-CoA carboxylase 1 (ACC1) as a critical metabolic regulator of adipose ILC2 maintenance and function.
2
1
223
How does obesity disrupt ILC2 function and adipose tissue hoemostasis? In our latest study, we identify acetyl-CoA carboxylase 1 (ACC1) as a critical metabolic regulator of adipose ILC2 maintenance and function.
2
1
223
We show that excess lipids in obesity suppress ACC1 in adipose ILC2s. Our findings also point towards an unexpected role of ACC1 in maintaining citrate shuttling and the NAD⁺/NADH balance. cell.com/cell-metabolism/ful… cell.com/cell-metabolism/ful…

Adipose ILC2s depend on acetyl-CoA carboxylase 1 to maintain metabolic health

Karagiannis and Theodorou et al. show that excess lipids in obesity impair adipose ILC2s via acetyl-CoA carboxylase 1 (ACC1). Deletion of ACC1 disrupts the citrate shuttle and the NAD+/NADH balance,...

cell.com
1
97
Congratulations to first authors @Fokaragiannis and Rafa Theodorou
37
Our findings also point towards an unexected role of ACC1 in maintaining citrate shuttling and the NAD⁺/NADH balance. cell.com/cell-metabolism/ful…

Adipose ILC2s depend on acetyl-CoA carboxylase 1 to maintain metabolic health

Karagiannis and Theodorou et al. show that excess lipids in obesity impair adipose ILC2s via acetyl-CoA carboxylase 1 (ACC1). Deletion of ACC1 disrupts the citrate shuttle and the NAD+/NADH balance,...

cell.com
1
43
Congratulations to first authors @Fokaragiannis and Rafa Theodorou!
18
Wilhelm Lab retweeted
Cell Metabolism@Cell_Metabolism
Sep 23
New! Online now: Adipose ILC2s depend on acetyl-CoA carboxylase 1 to maintain metabolic health dlvr.it/TVcSWf
20
51
2,973
Wilhelm Lab retweeted
SchabbauerLab@SchabbauerL
May 18
We are excited to see our beloved study on Macrophage Arginine metabolism in Neuroinflammation published today in #NatureImmunology. nature.com/articles/s41590-0…. It is time to celebrate 🍷🍻🥂

Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation

Nature Immunology - Kerndl and colleagues identify that arginase 1-expressing monocyte-derived cells mediate arginine catabolism and detrimental effects during experimental autoimmune...

nature.com
3
14
63
3,611
Wilhelm Lab retweeted
Wen Zhang@wenzhang1120
Feb 12
Honored to see our recent Nature study on neuro-epithelial circuits in anti-helminth immunity highlighted in this excellent News & Views. Many thanks to the authors @LabWilhelm for the thoughtful synthesis. doi.org/10.1038/s41590-026-0…
1
3
7
439
Wilhelm Lab retweeted
Elizabeth Emanuel@immunologyliz
Feb 10
A nice write-up from Nature Immunology about our recent paper! nature.com/articles/s41590-0…

Tuft cells feel the pain

Nature Immunology - Type 2 immunity in the gut is regulated by an interplay between epithelial and immune cells. A recent Nature paper shows that pain receptors amplify this response by promoting...

nature.com
2
11
31
2,656
Lipid metabolism and redox balance are linked in type 2 immunity! We found that allergen-induced #ILC2s and #Th2 cells require cysteine-driven glutathione synthesis to prevent #ferroptosis and support #lipid metabolism and expansion of type 2 immune cells in #asthma.
1
2
294
Our new paper out in @ImmunityCP Congratulations to first author Chantal Wientjens! cell.com/immunity/fulltext/S…

Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic...

Immune cells must modulate their metabolism to adapt to tissue constraints. Wientjens et al. show that allergen-induced ILC2s and Th2 cells require cysteine-driven glutathione synthesis to prevent...

cell.com
3
4
2,510
Wilhelm Lab retweeted
Immunity@ImmunityCP
10 Dec 2025
Online now: Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic airway inflammation dlvr.it/TPlGbt

Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic...

Immune cells must modulate their metabolism to adapt to tissue constraints. Wientjens et al. show that allergen-induced ILC2s and Th2 cells require cysteine-driven glutathione synthesis to prevent...

cell.com
18
54
5,576
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation | Nature Immunology nature.com/articles/s41590-0…

Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoprolifer...

Nature Immunology - Tuft cells constitutively express IL-25 to sustain ILC2 homeostasis in the intestine, but mechanisms driving IL-25 secretion have been unclear. Here, Feng et al. find that tuft...

nature.com
3
12
981
Alaaf!! 🎊🍾🥳🥳🥳
6
835
We are hiring! 📣Interested in how host metabolism, diets, #fasting and #ketogenesis affect the immune response? 👇We are offering a #postdoc position to work on the interplay of host metabolism and immunity. Apply by email or DM directly.
3
53
179
20,143
Thrilled to announce that our #SFB1454 got funding @UniBonn @IIIBonn #Metaflammation
DFG public | @dfg_public@wisskomm.social@dfg_public
25 Nov 2024
Die #DFG richtet zur weiteren Stärkung der #Spitzenforschung an den Hochschulen 7 neue #Sonderforschungsbereiche (SFB) ein. Die Themen reichen von Materialübergängen oder der Wiedervernässung von Mooren bis zur Immunregulation in der Leber. Einzelheiten: ➡️dfg.de/de/service/presse/pre…
6
5
53
5,603
Thanks so much DFG for funding our CRC #1454 #Metaflammtion for another 4 years. Looking forward to unravel the immune mechanisms underlying #obesity and #diabetes together with an excellent team of scientists. @UniBonn @ImmunoSens
DFG public | @dfg_public@wisskomm.social@dfg_public
25 Nov 2024
Die #DFG richtet zur weiteren Stärkung der #Spitzenforschung an den Hochschulen 7 neue #Sonderforschungsbereiche (SFB) ein. Die Themen reichen von Materialübergängen oder der Wiedervernässung von Mooren bis zur Immunregulation in der Leber. Einzelheiten: ➡️dfg.de/de/service/presse/pre…
12
679
Wilhelm Lab retweeted
Waggoner Lab@LabWaggoner
14 Nov 2024
Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation @Fer_NK_nando @TimMcCulloch nature.com/articles/s41467-0…
1
7
41
4,810
Wilhelm Lab retweeted
Laura Surace@surace_laura
12 Nov 2024
🚨 last weeks 🚨 1 phd position available in our Lab ! If you are interested in tumor immunology and immunometabolism contact us … info 👇 … 🙏 RT
1
12
49
9,287
Congratulations Anna, Ari and colleagues, really love the story!
Anna Molofsky@AnnaMolofskyLab
1 Nov 2024
Our latest paper with @Molofsky_lab is out! tweetorial to follow. Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior | Science science.org/doi/10.1126/scie… @jerika_barron @ Nick Mroz
4
462
Load more