Heisenberg Professorship for Immunocardiology @Uniklinik_hd
Heidelberg, Deutschland
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No longer the forgotten valve.
Check out our latest preprint on how tricuspid regurgitation accelerates heart failure.
doi.org/10.64898/2026.07.07.…
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Leuschner Lab retweeted
Using the first mouse model of tricuspid valve regurgitation, we identify a cardio-intestinal innate immune circuit in which chronic venous congestion reprograms monocytes into IL-6-producing drivers of heart failure.
doi.org/10.64898/2026.07.07.…
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Check out the latest issue of @CircRes with our Echo-Guided IR Method on the cover ♥️ 🥢
@CircRes May 9th Issue is Out! ahajrnls.org/3wPOBJJ
Cover: Representative IF staining of endothelial cells (magenta), inflammation (yellow), & WGA (green) in a 4-chamber view of a heart 7 days after Echocardiography-Guided Induction of I/R;nuclei-blue.
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In @Circres we describe a novel Echocardiography-Guided Method for Induction of Myocardial Ischemia/Reperfusion.
Check out the full study here: doi.org/10.1161/CIRCRESAHA.1…
Great collaborative effort with @leuschnerlab, @lavinelab, @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF
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scRNA-Seq profiling of 🫀interstitial cells reveals fibrosis in HFpEF to be distinct from HFrEF including the induction of basement membrane collagens and a protective ⬆️ of ANGPTL4 in murine and human HFpEF | led by @LauraWienecke and @jan_lanzer
doi.org/10.1007/s00395-024-0…
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What do Angptl4 and collagen IV have to do with fibrosis in HFpEF?🫀 Proud to have found some answers!🔬 Thanks to my co-first @jan_lanzer, all authors and our supervisor team for excellent support @LeuschnerLab @JulioSaezRod 👌🏻 link.springer.com/article/10…
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Molecular fibroblast activation patterns in heart failure.
link.springer.com/article/10…
ALT Integrated atlas of cardiac fibroblasts from different disease models. UMAP embeddings, showing the integrated fibroblast atlas colored by cell clusters, i.e. the integrated fibroblast states (IFS). Labels indicate possible fibroblast differentiations based on functional characterization.
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Check out our paper just published in Circulation
➡️ Translation controls inflammation after myocardial infarction
doi.org/10.1161/CIRCULATIONA…
This work was a huge collaborative effort over many years.
@dzhk_germany @DGK_org @VolkersMirko
Key findings + paper summary below 🧵⬇️⬇️⬇️
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Read my Tools of the Trade article, published in @NatRevCardiol, highlighting my experience with and the method of ultrasound guided induction of myocardial infarction:
rdcu.be/dLgU3
Thanks to @FloSicklinger & F. Leuschner for developing such an innovative method.
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Leuschner Lab retweeted
Couldn't attend the #Immuno-#Cardiology Symposium @FondationLeducq @jacksonlab? No problem-> read the report 'Linking immune modulation to cardiac fibrosis' here 👉 rdcu.be/dIUBP
#fibrosis #cardioimmunology
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A shortcut to the infarcted heart
Excited to share our collaborative effort with @DenisSchapiro lab led by @FloSicklinger and @FloWuenne. Using spatial omics technologies, we found a new way how monocytes sneak into the infarcted heart.
biorxiv.org/content/10.1101/…
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Leuschner Lab retweeted
I am very excited to share our lab's first preprint @uniklinik_hd together with the @LeuschnerLab. This study was led by @FloWuenne and @FloSicklinger. biorxiv.org/cgi/content/shor…
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