ALT SodA is important for S. aureus survival during osteomyelitis in hyperglycemic mice. Eight-week-old male mice were treated with STZ intraperitoneally for 5?days. Ten?days after the final injection, mice were infected with 1 � 105 CFU of WT, sodM::erm, sodA::tet, and sodA::tet sodM::erm S. aureus strains via intraosseous injection. (A) Weights were recorded every 24?h and normalized to the starting weight of each animal on the day of infection (percent weight). (B to E) Mice were sacrificed at day 14 postinfection, and the bacterial burdens (CFU) were enumerated in infected femur (B), kidneys (C), liver (D), and heart (E). Different shapes indicate data collected from 3 distinct experiments (n?=?10 mice per group). Dotted lines indicate limit of detection. Horizontal lines indicate means, and error bars represent SD.