Applied pathogen genomics laboratory at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Australia
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Latest work by @ouli_xie in collaboration with national partners including Sebastiaan van Hal @syd_health,
@syctong, @DrDavidAscher, Aimee Tan @McDevitt_Lab
and others. Please read Ouli's thread for more information on PBP mutations and penicillin MIC in S. dysgalactiae (SDSE)
Can Group C/G Streptococcus (Streptococcus dysgalactiae subsp. equisimilis, SDSE) become penicillin resistant? We report a case in an individual on prolonged penicillin prophylaxis. @MDaviesLab @TheDohertyInst journals.asm.org/doi/10.1128… 🧵👇
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Pleased to share our latest paper @NatureMicrobiol on the emergence of antimicrobial resistant S. pyogenes lineages driving scarlet fever in China - a collaboration w Dr Yuanhai You and the China CDC @MDaviesLab @mark_uq @XinweiRuan @TheDohertyInst
dlvr.it/TSB4lx 🧵👇
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Comparative clinical and genomic study of invasive SDSE v invasive S. pyogenes in Australia (and beyond). Rise of the clone..... SDSE stg62647! Beautiful work @ouli_xie (remember to read the supplementary material for more details). Powerful collaboration across borders. 🧵👇
Excited to share our latest paper on invasive Streptococcus dysgalactiae subsp. equisimilis (iSDSE) disease in Australia and in a global context. @syctong @MDaviesLab doi.org/10.1016/j.lanmic.202…
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In press article out now @LancetMicrobe! sciencedirect.com/science/ar…
Heard of SDSE? This under-recognised strep bacterium is causing a growing number of serious infections in Australia, with First Nations Australians disproportionately affected.
Learn more 🔗 bit.ly/3KDYy6r
@ouli_xie @syctong @MDaviesLab
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Collaboration is the key! @TheDohertyInst @UniMelbMDHS @MenziesResearch @MonashHealth @WestSydHealth
Excited to share our latest research published in @LancetMicrobe exploring epidemiology and lineage dynamics of invasive S. pyogenes across diverse regions of Australia. doi.org/10.1016/j.lanmic.202…. A huge collaboration with many partners @syctong @MDaviesLab @rh_chisholm. 🧵👇
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Please read the next S. pyogenes genomic epi instalment from the laboratory (thread below). Huge amount of work by 'Dr Dr' @ouli_xie. Many thanks to the multitude of collaborators who contributed to this important work.
Excited to share our latest research published in @LancetMicrobe exploring epidemiology and lineage dynamics of invasive S. pyogenes across diverse regions of Australia. doi.org/10.1016/j.lanmic.202…. A huge collaboration with many partners @syctong @MDaviesLab @rh_chisholm. 🧵👇
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Excited to share our new lab work - driven by our fantastic PhD student (now Dr) @magnus_gj with @HayesScience @syctong: Cataloging of chromosomal inversions in #StrepA reference genomes. Sets an analytical framework for investigations in other pathogens. academic.oup.com/nar/article…
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Pleased to share our latest collaborative research on the genomic epi of typhoid fever in Fiji published in @MicrobioSoc. Wonderful collaboration with public heath parters in Fiji/Aus. Evidence of 'selection' in the S. Typhi Vi capsule locus. microbiologyresearch.org/con….
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Special thanks to Dr Aneley Getahun Strobel @HayesScience @wytamma @BenjaminHowden @MulhollandKim @DickStrugnell1 and many others - especially the hospital/public health workers in Fiji @MOHFiji @TheDohertyInst @UniMelbMDHS @MCRI_for_kids with support including @gatesfoundation
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Honoured to be a member of the StrepA Outbreak Prevention Team @eurekaprizes 2024. Huge thanks to the many students and staff that facilitate the magic of team work and collaboration. Congrats to all #EurekaPrizes finalists!
🏆 Huge congrats to @MDaviesLab from @TheDohertyInst who, together w/ collaborators at @IMBatUQ, won the prestigious #EurekaPrize for their crucial work on tracking Strep A spread and advancing vaccine development. [Watch piped.video/bIqXK4VfFMI]
@UniMelbMDHS @UniMelb @TheRMH
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Out now: @magnus_gj latest PhD work: journals.asm.org/doi/10.1128… Systematic evaluation of existing #StrepA transposon mutagenesis work using a pan-genome framework. Interactive html is included for searching of your favour strepA gene: zenodo.org/records/10796268 @HayesScience @syctong
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With an ageing population, we should be wary of the clinical burden of pathogens such as SDSE. Timely review led by the talented @ouli_xie. More clinical information on SDSE disease is needed (watch this space....)
Is Streptococcus dysgalactiae subp. equisimilis (SDSE) just the poor cousin of S. pyogenes? Although it mostly causes disease in adults, there's actually much clinical and genomic overlap! See our review just out in CMR @syctong @MDaviesLab @TheDohertyInst journals.asm.org/doi/10.1128…
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We have a research position in 'Microbial Bioinformatics' available in our laboratory. Masters/PhD level applicants with bacterial genomics experience are encouraged to apply. Come and join us @TheDohertyInst @UniMelbMDHS! Applications close 17 June 2024 jobs.unimelb.edu.au/caw/en/j…
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Mark_Davies_Lab retweeted
World-first research shows Streptococcus pyogenes (#StrepA) & emerging pathogen Streptococcus dysgalactiae subsp. equisimilis (#SDSE) coexist & share genes, opening up potential vaccine target pathways.
doherty.edu.au/news-events/n…
@ouli_xie @syctong @MDaviesLab @UniMelbMDHS @TheRMH
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Excited to see our latest collaboration in print. Fantastic analysis driven by the talented @ouli_xie . Much still to learn about #strepA and #SDSE transmission and associated clinical genomic epidemiology. @TheDohertyInst @UniMelbMDHS
Great to share our latest paper in @NatureComms examining real-world transmission interactions between S. pyogenes and the emerging pathogen S. dysgalactiae subp. equisimilis (SDSE) doi.org/10.1038/s41467-024-4…
@syctong @MDaviesLab @TheDohertyInst + many collaborators!
🧵👇
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New global genomic framework for SDSE from our team at the @TheDohertyInst @UniMelb and @DrDaveMacca @usceduau with many international partners. Big shout out analytical skills of @ouli_xie. Refer to thread 👇for key messages. doi.org/10.1038/s41467-024-4… More SDSE news coming soon!
Excited to share our Streptococcus dysgalactiae subsp. equisimilis (group C/G strep, SDSE) population genomics study highlighting its overlap with S. pyogenes (group A strep). Made possible by many partners @MDaviesLab @syctong @DrDaveMacca @TheDohertyInst rdcu.be/dA6Ye
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Mark_Davies_Lab retweeted
A great and inspiring 1.5 day visit to Doherty Institute and MCRI in Melbourne kindly hosted by Mark Davies and @JoshOsowicki Apparently just missed out on @Pink singing for the kids at the hospital yesterday. You rock 🤙!
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Huge effort by a huge consortia! Amazing resource for the global community.
Awesome🇦🇺team science @natcomms
Spearheaded by André Mu @muandre01 and anchored by Mark Walker @UQ_News, paper applies a standardized genomic, transcriptomic, proteomic + metabolomic tech framework to leading sepsis pathogens -> now open source for all!
nature.com/articles/s41467-0…
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Timely review in @NatureRevMicro by our national team on the latest research developments in #StrepA pathogenesis, host responses, genomic epidemiology, AMR and vaccine development.
Including @magnus_gj @mark_uq @UQ_News @TheDohertyInst @UniMelbMDHS rdcu.be/c7ldw
Our team's latest work published in @NatureRevMicro. Here we cover the most recent advances and developments in Group A Streptococcal research
nature.com/articles/s41579-0…
Well done Stephan Brouwer, @tania_riv_her @MDaviesLab & team! #GroupAStrep
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