This is the first result from our new molecular biology lab, where a team of Anthropic biologists is using Claude to explore and accelerate fundamental biology research. There, Claude works through data and literature to generate hypotheses and candidate biological systems to study. After our scientists review Claude’s hypotheses, they test the most promising ideas, with all lab work done by our scientists. We’d like to extend this approach to a broad range of problems—in genomics and in other fields. If you have a proposal for a research question, we’d like to hear from you.

added a little bit of spice to the bookmark animation, opus 5.5 btw

What can us, engineers else learn from designers and design engineers? Turns out there’s lots, based on talking with one of the best design engineers in the industry, @Mappletons. Timestamps: 00:00 Intro 03:24 From anthropology to tech 10:18 What does a designer do? 18:23 How Maggie works 24:55 The case for planning with physical tools 31:53 Why Maggie is learning woodworking 33:13 Design engineers and engineering constraints 38:49 How Maggie uses Figma 40:30 Design at GitHub Next 45:12 How has AI changed design 50:37 When models design and why humans are still needed 53:30 UX and UI 58:29 Capability gaslighting 1:00:33 One Developer, Two Dozen Agents, Zero Alignment 1:07:21 Craft and AI tells 1:14:17 Visual gardens, home-cooked software, and barefoot developers 1:21:02 Advice for engineers and lessons from anthropology 1:25:34 Book recommendation Brought to you by: • @turbopuffer – a vector and full-text search engine built on object storage. It’s fast, cheap, and extremely scalable. turbopuffer.com/pragmatic • @AntithesisHQ – verify your system’s correctness without human review or traditional integration tests – and avoid bugs or outages. antithesis.com/pragmatic • @EntireHQ – every agent prompt, tool call, stored in your repo, and mirrored. Set up with one click: entire.io/pragmatic Hope you enjoy this unusually visual episode - thanks again, Maggie!