Dr. Eduardo Marban | Executive Director, Smidt Heart Institute @CedarsSinai Views are my own, not institutional policy!
Cedars-Sinai Medical Center
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Enjoyed my visit to @dgsomucla and the opportunity to discuss #exomers for #scleroderma, #Duchenne and #arrythmogenic #cardiomyopathy
@TheIbrahimLab @AleCiulloPhD @rrogerslab @EugenioCingolan @soussi_salwa @XMichaelJonesMD
Delighted to have @MarbanLab for an inspiring talk on translating cardiosphere-derived cell biology into RNA therapeutics. Fascinating insights into extracellular vesicles, Y RNA, macrophage reprogramming, tissue repair, and TY1; from discovery to clinical translation. #UCLA
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Looking forward to sharing our work on #exomers with friends and colleagues at @dgsomucla next week!
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Proud of my two former trainees (the poster, Eugenio, and the speaker, Tetsuo)!!
Fantastic lecture on #AF by Prof Tetsuo Sasano from Tokyo Institute of Science 🇯🇵 @CedarsSinaiMed - from basic mechanisms to improving detection on a #taxiride 🚕 or #hotelbed 🏨 CedarsSinai @APHRSOfficial @HRSonline
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Eduardo Marban, MD, PhD retweeted
Suggesting a novel therapy for #SystemicSclerosis: doi.org/10.1172/jci.insight.…
Eduardo Marbán & team @Marbanlab @CedarsSinai report that an orally delivered noncoding RNA (TY1) reduces inflammation and organ fibrosis in models of systemic sclerosis through inhibition of the cGAS/STING axis. The authors employed in vitro and in vivo models and evaluated skin, lung, and heart.
The video shows TY1 treatment in preclinical models of systemic sclerosis.
@AleCiulloPhD @TheIbrahimlab @the_asci
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Eduardo Marban, MD, PhD retweeted
Noncoding RNA TY1 reverses fibrosis in systemic sclerosis by attenuating the cGAS/STING pathway @JCI_insight @MarbanLab
insight.jci.org/articles/vie…
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Excited to share our latest paper in @JCI_insight, with @XMichaelJonesMD & @TheIbrahimLab : #TY1, an #RNA #exomer drug, reverses the key disease manifestations of #scleroderma in 2 mouse models & in human #SSc cells. The drug works well orally & has unprecedented disease-modifying bioactivity in this horrible disease. Next step: clinical trials!
insight.jci.org/articles/vie…
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Eduardo Marban, MD, PhD retweeted
Percutaneous Atrial Delivery of TBX18 Creates a Stable Supraventricular Biological Pacemaker in Porcine Sick Sinus Syndrome | JACC: Clinical Electrophysiology jacc.org/doi/10.1016/j.jacep…
@JACCJournals #JACCEP #Biopacer
#Biopace #CRM #RhythmsAndMore
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Lancet paper provides important independent validation of the HOPE-3 trial. Let’s get #deramiocel to all #Duchenne patients in dire need.
We're pleased to share that @TheLancet has published results from Capricor's Phase 3 HOPE-3 trial evaluating Deramiocel in #Duchenne muscular dystrophy.
The independent peer-reviewed publication validates the trial's design, statistical methodology and findings. HOPE-3 met its primary endpoint, with Deramiocel slowing upper limb function decline by 54 percent versus placebo (PUL 2.0, p=0.03) and demonstrating a clinically meaningful cardiac benefit.
Read more here: thelancet.com/journals/lance…
We are grateful to the patients, families, investigators and study teams who made this research possible.
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This week’s journal club featured Kara Tsi on #LINE1 derepression in aging, @coralf_reef on #ExtracellularVesicle therapy for #afib, and @AleCiulloPhD on microglia in demyelinating diseases. The diversity of topics reflects our group's scope of interest: no preset limits!
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Working with @rrogerslab of Cedars-Sinai, Jonah Zarrow, PhD has developed new #exomers with RNase-resistant backbones & bioactivity against #DNA damage. Supported by our #T32 postdoctoral training grant from @NIH
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Honored to have been chosen as the 2026 Arthur C. Guyton Distinguished Visiting Professor in Physiology & Biophysics at @UMMCnews. Below, joining me in flanking the iconic portrait of Guyton, are George Souza, my gracious host John Hall & Ana Omoto.
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Sharing a thoughtful story from Cedars-Sinai on the discovery process that led to deramiocel for Duchenne cardiomyopathy. It’s been an amazing journey!
cedars-sinai.edu/health-scie…
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This is not only a loss to cardiology at large, but also a personal loss. Gene went out of his way to engage me and serve as a mentor over the years, even if at a distance. Our paper, "Training the Clinician Investigator", has some helpful pearls: ahajournals.org/doi/10.1161/…
The American Heart Association mourns the passing of the legendary cardiologist Eugene Braunwald, M.D., widely recognized as one of the most influential figures in the history of cardiovascular medicine. Over seven decades, his work reshaped the understanding and treatment of heart disease, leading many to call him the father of modern cardiology.
Braunwald was a lifelong contributor to the American Heart Association, helping advance its research and scientific mission, and was honored with some of the Association’s highest honors for his lasting influence on cardiovascular care and research. His influence extended well beyond his own discoveries, as generations of Association‑supported investigators, clinicians and academic leaders were trained by Braunwald or guided by the clinical trial standards and mentorship models he helped establish.
newsroom.heart.org/news/amer…
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This week’s lab meeting feat. @coralf_reef discussing his work w/James Dawkins & @EugenioCingolan on biological alternatives to ablation for #VT. Much promise to move from tissue destruction to tissue healing as a therapeutic strategy.
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We were pleased to host @kory_lavine of @washumedicine as @SmidtHeart visiting professor. Kory’s cutting edge work on innate immunity is identifying new #therapeutic targets for #heartfailure. @LavineLab
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#journalclub featured Adarsh Balaji @ke_liaoPhD & @TheIbrahimLab each reviewing novel #therapeutic interventions— self-amplifying #mRNA post-MI, “scarless” circular #RNA to improve CAR-T, & “flexomers” for Lewe body dementia & related synocleinopathies. Terrific presentations!
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