Biophysicist | #Postviral syndromes, #longCOVID, #PACVS | Open Source Medicine Foundation | opensourcemed.info
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When it comes to moving the needle on health outcomes, its important to look at feasibility, cost, and availability/access.
This week we demonstrate how Open Source Medicine accomplishes this.
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Matthew Halma retweeted
Halo 3 released exactly 19 years ago.
A different world, back then.
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RECOVER-TLC has shared the list of biomarkers they will be analyzing in their upcoming clinical trials. Their team reviewed hundreds of Long COVID studies to identify clinically promising biomarkers that were reported as dysregulated in two or more studies published in peer-reviewed journals.
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Matthew Halma retweeted
RECOVER-TLC has published a list of 82 blood biomarkers to be measured in its Long COVID treatment trials.
It's not a diagnostic test, and it won't change anything in the clinic for now. But it's worth looking at what's on the list, and especially what isn't🧵
FNIH RECOVER-TLC researchers reviewed hundreds of Long COVID biomarker studies and prioritized 82 blood markers spanning immune, vascular, inflammatory, metabolic and neurologic pathways.
No single marker can yet diagnose Long COVID.
fnih.org/our-programs/recove…
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Matthew Halma retweeted
I think @drmichaellevin is doing some of the most interesting science out there. In the future medicine will expand from chemistry towards bioelectricity, basically learning to reprogram cells through electrical signals. The science is a bit early still but I think the next big pharma companies will be in that field.
My conversation with @drmichaellevin, a biologist at Tufts University whose research explores bioelectricity, regeneration, morphogenesis, and how cells collectively process information to build and repair bodies.
Timestamps:
0:00 - Causes and downstream effects of aging
3:31 - Bioelectric patterns and memory in regeneration
9:30 - Cracking the bioelectric code
12:10 - The boredom theory of aging
23:11 - The germline is ageless
25:45 - Bioelectricity and epigenetic reprogramming
27:15 - What experiment could falsify Mike’s ideas?
29:13 - The role of aging clocks and biological age
31:06 - Top-down control in biological systems
39:09 - Consciousness and its implications
48:25 - Changing human goals and preferences
51:30 - The future of medicine
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Basel University Hospital, 22 patients. Exercise lactate rose from 1.23 to 7.11 mmol/L, pointing to altered energy metabolism in some Long COVID patients.
But protocol strongly changed peak values, so lactate is not yet diagnostic.
sciencedirect.com/science/ar…
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Now the disease cohorts. These upend typical assumptions about vaccine adverse events, these happened months later in many cases.
Often, it is far more difficult to attribute adverse events if they occur a significnat duration after vaccination. Even adverse event monitoring is typically concentrated a few days after the vaccination.
A 2014 follow-up isolated the ME/CFS-fibromyalgia slice: 19 patients immunized 1990–2008.
Mean onset 38.6 days (range: days to a year).
Agmon-Levin et al., Immunol Res 2014: pubmed.ncbi.nlm.nih.gov/2542…
A 2012 Shoenfeld-group series reviewed 93 US patients diagnosed with immune-mediated disease after Hep B vaccine.
Mean onset: 43 days after the last dose.
Zafrir et al., Lupus 2012: pubmed.ncbi.nlm.nih.gov/2223…
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Now for pharmacovigilance, which is where the timescales get very long.
A 2025 analysis of 76,887 VAERS reports after Hep B vaccine found disproportionality for tendon fibrosis (ROR 251.8), myofascitis (ROR 107.5), fasciitis (ROR 71.5), and osteoarthritis (ROR 7.6).
Most events clustered within 30 days.
Myofascitis mean onset was ~1,671 days, consistent with slow aluminum release.
Sun et al., Front Public Health 2025: doi.org/10.3389/fpubh.2025.1…
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Gulf War Illness, post-HPV, ASIA-after-Hep-B, and PACVS sit in the same clinical neighborhood: fatigue, widespread pain, cognitive impairment, sometimes autoantibodies or persistent injection-site granulomas.
Different antigens. Some shared adjuvants. Similar presentation.
Broader post-vaccination syndrome literature: vaccinedatanavigator.org/pav…
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Vaccine adverse events are treated as a days-to-weeks problem.
A 2025 analysis of 76,887 Hep B VAERS reports found myofascitis with a mean onset of 1,671 days.
Pathologists have been photographing macrophages at the injection site since 1998, containing aluminum from the vaccine adjuvant.
Post vaccine ME/CFS-like symptoms didn't begin with COVID.
Hepatitis B predates it by 3 decades. Same symptoms: fatigue, widespread pain, cognitive complaints, sometimes autoimmunity.
The paper trail. 🧵
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First, the lesions.
Imaging studies have looked into macrophagic myofascitis developing after aluminum adjuvant containing vaccination, in this case it took 11 months (median value) from vaccination to the development of symptoms.
Gherardi et al., Brain 2001: pubmed.ncbi.nlm.nih.gov/1152…
Importantly, aluminum from the adjuvants was found in biopsies of the lesions.
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Matthew Halma retweeted
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Why do a small minority of people develop chronic illness after spike protein exposure — from infection or vaccination — while most don't?
I reviewed the mechanistic candidates. The honest headline: we have a long list of plausible mechanisms and almost no validated risk factors. 🧵
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Post-vaccination syndrome is not a COVID invention.
The anthrax vaccine has been in this argument since the Gulf War — longer than COVID, longer than HPV. Same cluster: fatigue, joint pain, cognitive collapse. Different decade. Here’s the file. 🧵
Background: after DoD's mandatory 1998 anthrax vaccination program, concerns arose that AVA might be linked to the chronic multisymptom illness seen in Gulf War veterans — fatigue, joint pain, cognitive complaints, widely known as Gulf War Illness.
Photo Credit: Rusty Russell / Getty Images
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GWI is one case of a broader class of syndromes: post-vaccination syndromes may share an etiology.
One review puts Gulf War Illness next to post-HPV vaccination syndrome and macrophagic myofasciitis — same core cluster of fatigue, widespread pain, and cognitive impairment.
The symptomology, and potentially the etiology, is not unique to anthrax vacciens, HPV vaccines, or COVID-19 vaccines.
sciencedirect.com/science/ar…
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Explore Post-Vaccination Syndromes at vaccinedatanavigator.org/pav…
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New on VaccineDataNavigator.org
a dashboard on Post-Acute Vaccination Syndromes (PAVS) — chronic, ME/CFS-like illness reported after vaccination, across multiple vaccines, not just COVID-19.
vaccinedatanavigator.org/pav…
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PACVS after COVID-19 vaccines gets most of the attention, but it's not unprecedented.
Similar clusters of fatigue, autonomic dysfunction, and pain have been reported after HPV, hepatitis B, and anthrax vaccination, and aluminum adjuvants have their own history (MMF, ASIA).
The dashboard grades the evidence for each: separating established causal links (like Pandemrix and narcolepsy, or VITT and anti-PF4 antibodies) from contested syndromes with case series but no confirmed mechanism (HPV, hepatitis B/ASIA, anthrax/Gulf War Illness).
The goal is to lay out what's actually documented for each vaccine: symptom clusters, onset windows, key studies, regulator positions, and where the evidence is thin. Full comparison table and per-vaccine detail at the link.
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