Antivirals (taken in first hours after infection or symptoms) are the only thing that can prevent #LongCovid . If false or not efficient paths are taken for the cure of Long Covid, we will forever be at risk of several cumulative #LongCovid

Medical University of Vienna, 95 people. SARS-CoV-2 proteins persisted 4 to 6 months after infection. High N-protein tracked with vascular inflammation, while experiments showed N-protein directly activated endothelial inflammation through TLR4. portlandpress.com/clinsci/ar…

🏥 Le fléau des erreurs médicales à l’hôpital, à l'origine de 30 000 morts chaque année : "Elles poussent sur le terrain fertile de la dégradation du système de santé, mais plus de la moitié seraient facilement évitables." A dérouler ⤵️ @le_Parisien 1/6 leparisien.fr/societe/sante/…

Le Covid Long, c’est aussi des dépenses de santé qui s’accumulent, parfois pendant des années, alors même que les revenus diminuent. Un témoignage qui rappelle le coût humain et financier de la maladie. #CovidLong #LongCovid #ApresJ20

🚨Important: @ngklimas sipavibart trial needs to enroll 5 more Long COVID participants by of this month! Details: 👇 teddit.net/r/covidlonghauler…

RECOVER-TLC has shared the list of biomarkers they will be analyzing in their upcoming clinical trials. Their team reviewed hundreds of Long COVID studies to identify clinically promising biomarkers that were reported as dysregulated in two or more studies published in peer-reviewed journals. 1/

✨Dr. Nancy Klimas @ngklimas talks viral persistence and viral reactivation in Long COVID & MECFS✨👀 For those who may not know, Dr. Klimas is currently running a trip of sipavibart monoclonal antibodies at @NSUFlorida! Some key takeaways: A leading indicator of who goes on to develop Long COVID after their acute infection is whether they end up with reactivated Epstein-Barr virus. (Not only that it reactivates during acute infection, but that it *stays* reactivated after acute infection). This is because while everyone who’s had EBV previously still carries it in their body. Most people’s immune systems are able to keep it suppressed, but when a stressor such as COVID weakens the immune system, these latent viruses such as EBV may begin to escape its control. Persist infection with EBV and other viruses, such as herpesviruses, Coxsackie virus, and CMV, is also thought to be a cause of MECFS. In these bases- both MECFS and LC- Dr. Klimas says the question is, “Can you treat it by treating the infection that you found? Or do you need to strengthen the immune system?” 👉For certain of these viruses, it’s possible to take an antiviral for a period of time. Even if it’s a virus that can never be totally cleared from the body, such as EBV, sometimes taking a course of antivirals to suppress the virus for a time can give the immune system a chance to recover so it can then keep things under control moving forward. 👉Dr. Klimas also mentions interferons as a treatment. An interferon is a class of proteins that our immune system makes to fight viruses. They are also made synthetically and used as medications that the patient can inject. (Interferons have also been found helpful in acute COVID, and we’d love to see them tested in Long COVID!). 👉Dr. Klimas also mentions that certain foods and supplements can also help the immune system to recover. In addition to reactivated latent viruses, Dr. Klimas also mentions the growing evidence for SARS-CoV-2 persistence in the GI tract, as well as potentially other parts of the body, as the cause of Long COVID.🦠 As research progress, it would be interesting to see if the same concepts she mentions for treating reactivated viruses could also be used to fight persistent SARS-CoV-2. Maybe rather than trying to eliminate every single viral particle with antivirals, which may be impossible given all the sites in the body it seems able to invade, perhaps what we need to be focusing on is giving the immune system enough if a boost that it can fight back, and get everything under control again. 1/ piped.video/9J-WO9dcoWk?si=EOMS…

Most of life happens between appointments. Research should reach those moments, too. We built TrialPilot to connect researchers and people living with invisible illness and learn from everyday life, together. Here’s our first demo

Cette résolution porte notamment sur la reconnaissance du #CovidLong comme maladie systémique, les parcours de soins, la recherche, la formation des professionnels et les conséquences socio-économiques.

🇧🇪 Une avancée importante pour le #CovidLong ! Nous félicitons @TooLongCovidBe, les patients-experts, les associations et les professionnels auditionnés pour leur contribution à l’adoption d’une résolution commune par la commission des Matières transversales du Sénat belge. 🧵👇

Perte d’autonomie, difficultés à accomplir des gestes ordinaires, mais aussi lourdeur des démarches administratives liées à leur situation de #handicap et à leur prise en charge : le #CovidLong bouleverse profondément leur vie.

Almost like we had a gain of function designed virus, that causes immense vascular damage, infect almost everyone alive multiple times and still continues to do so.

🦠 Coucou, c'est le #Covid ! Reprise épidémique cet été, qui s'accélère depuis la rentrée : "Les douleurs se sont intensifiées mardi, on a probablement fait un cluster !" Comme l'an dernier, en somme. Petit fil ⤵️ @le_Parisien 1/6 leparisien.fr/societe/sante/…

AI Drug Discovery Hits a New Bottleneck: Experimental Validation AI can now generate drug candidates faster than labs can test them, shifting pharma’s challenge from molecular design to experimental validation. Sponsored by #ProBio hubs.li/Q04y1SRg0

Stem cells appear exceptionally good at donating mitochondria to other cells in need.

The currently dominant SARS-CoV-2 variant, NB.1.8.1 (nicknamed "Nimbus"), spreads more easily than previous variants because Nimbus does not cause the major symptoms, such as high fevers or persistent coughs, and infected inviduals spread the virus unknowingly. Nimbus is quietly spreading like "Ninjas."

Simplified: Claude scanned a huge DNA database and found a new enzyme system hiding in viruses that infect bacteria. Its DNA has a repeating pattern that looks like CRISPR, the tool scientists use to edit DNA. What it actually does is still unknown, and lab tests are ongoing.

University of Virginia, >3 million patients plus mouse MS models. K-9 reversed vision loss and paralysis in mice by blocking the inflammasome, protecting myelin and axons. Human claims data also linked related drugs to fewer MS diagnoses and relapses. nih.gov/news-events/news-rel…

Lily Emmanuel developed fatigue, brain fog, breathing problems and multi-system illness after suspected COVID. Years of fluctuating disability led her into Long COVID research, where she now helps shape clinical trials. fnih.org/patient-engagement/…

We are conducting a study on your diagnostic experiences with long COVID. Your participation is important for the research. Click on the link below to participate, and share the study if you can. Thank you! tinyurl.com/Rutgers-longCOVI…

« Je croyais que le Covid, c’était fini ! » : attention, les infections se multiplient depuis la rentrée ➡️ l.leparisien.fr/SJsd