What’s the link between the fats you consume and #cancer? A study from @MuzumdarLab finds it’s the type of fat you consume when it comes to #pancreaticcancer. Lisa Carberg explains below. @YaleCancer @YaleGICancers

Today at 12pm, we are pleased to welcome Dr. Anirban Maitra @Aiims1742 for our #GrandRounds and Koenigsberg Lecture! Dr. Maitra will present "Mediators of Restraint in Early Pancreatic Neoplasia." Join us in Smilow Auditorium or online via Zoom: bit.ly/4gWZv7G. @SmilowCancer @Perlmutter_CC

#InsideYaleLabs 🧬 Most of human genetic diversity lies in non-coding DNA. The Reilly Lab at Yale Genetics uses machine learning & CRISPR-based tools to uncover how non-coding variants shape biology & disease risk. 🔬 See more in the video below 👇 piped.video/watch?v=BW6RWTIP…

Congratulations @DrJeremyJacox, recipient of a Seed Grant from the @HirshbergFound. The grant program provides early funding to support basic scientists and clinicians to test innovative ideas for improving diagnosis and developing new treatment modalities for #pancreaticcancer. pancreatic.org/research/seed… @SmilowCancer

In new #pancreascancer research, @MuzumdarLab et al. find that the pre-existing molecular state of a #PDAC cell exerts greater influence over how a #KRAS mutation behaves than the identity of the mutation itself. medicine.yale.edu/cancer/pub… @SmilowCancer @MolecularOmics @YanixaQuinones @Yanshen73854711

#InsideYaleLabs:🔬 Cancer doesn't develop in isolation - genetics, environment & the host all play a role. @MuzumdarLab at Yale Genetics uses engineered models to uncover what drives cancer progression & how to stop it Check out the full video below 🎥 piped.video/watch?v=o9EnWL2e…

Excited to share our latest study led by @YanixaQuinones in collaboration with @Yanshen73854711! We find that the pre-existing molecular state dominates over the effects of specific #KRAS mutations in #PancreaticCancer cells. @YaleGenetics @YaleCancer academic.oup.com/molecular-o…

.@samirzaidi received an @AACR Trailblazer Cancer Research Grant earlier this year, and in the latest @CD_AACR he shares a commentary on his research project, Decoding Lineage Plasticity as the Engine of Therapy Escape." aacrjournals.org/cancerdisco… @SmilowCancer @OncoAlert

Join us! @YaleCancer @Yale @YaleMed @YaleWestCampus

📢 Postdoc position open in the Chioccioli Lab @YaleMed We study alveolar stem cell fate, injury and repair — live imaging of precision-cut lung slices, mouse genetics, single-cell genomics. Bioinformatics a plus. Closes 22 Sept. DM me or email for details. Please share! 🫁

With the recent FDA approval of #daraxonrasib for patients with advanced #pancreaticcancer, there is a lot of excitement among patients and clinicians. Dr. Alexander Jordan, explains more: "Daraxonrasib represents a major advance in the field. The results of the trial were exciting because daraxonrasib almost doubled the overall survival and risk of death was ⬇️ by 60%, numbers which have never been seen before in a pancreatic cancer trial. While these results are exciting, this is only the beginning as RAS inhibitors will likely be used in multiple different treatment settings and tumor types." @SmilowCancer @YaleGICancers

Great story on the multiple (now cell cycle phase-dependent) functions of METTL3, including a previously unappreciated role in transcription elongation for faithful mitosis. Congrats, #ClaudioAlarcon and @KabecheLab! @CancerYale @YaleCancer @YaleWestCampus medicine.yale.edu/news-artic…

We say goodbye to postgraduate associate Meera Kharwa, who contributed to our work on dietary fats and #PancreaticCancer. Good luck, Meera, on your next scientific adventure! @nyulangone

It was wonderful to host Biomed SURF @AmericanCancer Scholar Diego Torres in our lab this summer! Diego knocked it out of the park on his final elevator pitch and poster presentation on #PancreaticCancer #Immunology! @YaleCancer @YaleMed @YaleMDPhD

Congrats to the Alarcón and Kabeche lab on their Mol. Cell paper linking RNA modification to control of the cell cycle. More great work from YCBI labs. cell.com/molecular-cell/full…

A new study published in @Nature by @S_J_Aitken shows how an individual's inherited genetic background shapes cancer risk, how tumors evolve, and how aggressively they progress + could lead to more personalized cancer prevention and treatment. medicine.yale.edu/cancer/pub… @SmilowCancer

Congrats to Jiaze Liu and the Ferguson Lab @LemmonFerguson for your poster "Revisiting EGFR Antibodies with Unexplained Effects on Receptor Activation" awarded at the 40th Anniversary Symposium of The Protein Society! #YCBI @YaleWestCampus @YalePharmGrad @YalePharm @YaleCancer

Glad to share our latest publication in Science! This work reports: 🧬 the first single-cell 3D genome atlas of human tonsil and B cell immunity, 🧬 the first image-based 3D genomics dataset of any human tissue, 🧬 a new function for cohesin loop extrusion, and 🧬 a novel chromatin "curl" structure. Antibody-mediated immunity relies on the generation of point mutations in rearranged immunoglobulin (Ig) loci of activated germinal center (GC) B cells. This process - called somatic hypermutation (SHM) - allows for antibody affinity maturation but also acts at certain non-Ig sites in the genome, thereby contributing to mutations and chromosomal translocations that drive B cell oncogenesis. My collaborator Prof. David Schatz's previous work indicates that SHM susceptibility is controlled by the cooperative action of cis-acting SHM target elements and the architectural properties of topologically associating domains (TADs), but how the genome is spatially organized across multiple length scales as GC B cells develop and activate SHM and how 3D genome architecture influences the targeting of SHM remains unknown. To test the functional requirement of 3D genome organization for SHM, in this work we developed a 3D genome and spatial transcriptome toolbox optimized for clinical tonsil tissue, and used it to define single cell 3D genome architectures and nuclear organization in GC B cells undergoing SHM in normal human tonsil samples and in malignant GC-derived human B cell lymphoma cell cultures. Our new work generated the following key insights: 🧬 At the large scale, the nuclear positioning of TADs is linked to SHM susceptibility, with the nuclear periphery being more permissive to SHM and the nuclear interior being more protected from SHM. 🧬 At the fine scale, increased intra-TAD looping contacts in gene regions are associated with SHM susceptibility. 🧬 Most importantly, through rapid, targeted degradation of cohesin component RAD21, our new results provide the first direct evidence that the cohesin mediated loop extrusion is essential for SHM. We further showed that the effects of loop extrusion on SHM cannot be solely attributed to transcription activity changes. This represents a brand new function of the famous loop extrusion process. 🧬 In addition, we serendipitously discovered a novel chromatin “curl” structure – a chromatin loop with two long (~25 kb) stem regions aligned in parallel with each other (distinct from e.g., CTCF anchored chromatin loops where two stems are aligned in an anti-parallel fashion). To our best knowledge, this is the first report of such a structure outside of the contexts of DNA recombination/transposition. I'd like to thank all my co-authors, especially co-corresponding author legendary immunobiologist Prof. David Schatz, and co-first authors Yubao, Jianshu, and Yuan. It has truly been a wonderful experience working with you. Link to paper: science.org/doi/10.1126/scie…

A 3D genome atlas of human tonsil and the role of loop extrusion in B cell somatic hypermutation @SStevenWang @Yale @ScienceMagazine @ChengYubao science.org/doi/10.1126/scie…

Please repost! We are seeking #PostDocs to join our lab in @YaleGenetics @YaleCancer @CancerYale to study #genetic and #host drivers of #PancreaticCancer and #LungCancer. Check out our newly updated website for more lab details! medicine.yale.edu/lab/muzumd…