Examining the function of sperm small RNAs at @ChildrensPhila and @Penn 🇦🇺 in 🇺🇸 Avid list-maker, lover of the sky and all things science ☀️⚽️🔬
Philadelphia, Pennsylvania
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Excited to have this published! We identify a subset of microRNAs acquired by sperm from the epididymal epithelium that regulate gene expression in preimplantation embryos > cell.com/cell-reports/fullte…
Huge thanks to @ColinConine for the support and guidance during this project
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The 'swollen' phenotype was from epididymal tubule breakdown and cell infiltration and was accompanied by many gene changes. Interestingly, while offspring of germ-free dads didn't show the severe swollen epididymis, they shared many epididymal gene changes.
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If you're interested read it in @ReprodJournal ! Big thanks to the team, @ColinConine @TakuKambayashi Simon, Jordan, Maddie, Molly & Mike
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Working with germ-free mice with the @TakuKambayashi Lab we saw a 'swollen' epididymal phenotype occurring, so we took a closer look doi.org/10.1530/REP-24-0204
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A lack of commensal microbiota influences the male reproductive tract intergenerationally in mice doi.org/10.1530/REP-24-0204
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Natalie Trigg retweeted
Pleased to share my latest review article published with @SpringerNature in @NatRevUrol: Exploring the pathophysiological effects of hypoxia on testis function and spermatogenesis url.au.m.mimecastprotect.com…
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🔥🔥 A modest increase in temp doesn't affect sperm functionality but does alter sperm small RNAs, embryo dev and gene expression in mice plus more. pnas.org/doi/10.1073/pnas.24…
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This one was a big group effort! Not possible without @JESchjenken, @BrettNixon13 and the rest of the team
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Natalie Trigg retweeted
📢Postdoc available! We are looking for curious minds to answer big questions using epigenome editing
Join us at @EMBLRome - we offer training, supportive environment, top salary and scientific excellence. Also - sun, culture & Italian food😉
Info+apply:
embl.org/jobs/position/RM001…
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Natalie Trigg retweeted
@CTamessar from @UON_research @HMRIAustralia paper on the influence of seminal fluid extracellular vesicles (SFEV) on sperm function now published. Here we show that SFEVs deliver cargo to sperm to elicit subtle changes to their function@Repro_Fertility
url.au.m.mimecastprotect.com…
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Interested in studying the impact of environmental stressors on sperm epigenetics? A PhD position is open to domestic candidates to work in @BrettNixon lab. See link for more details or get in contact! @UON_research @HMRIAustralia newcastle.edu.au/study/resea… via @uni_newcastle
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Natalie Trigg retweeted
The first publication exclusively from my lab! Led by the amazing @NATrigg (who I will let tweet more details)
Epididymal acquired sperm microRNAs modify post-fertilization embryonic gene expression dlvr.it/TCk2wx
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Natalie Trigg retweeted
Epididymal acquired sperm microRNAs modify post-fertilization embryonic gene expression dlvr.it/TCk2wx
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Natalie Trigg retweeted
A year and a child later, LIDAR is out!
Thanks to everyone involved - especially Roberto. His unconditional support and great mentorship made this possible.
@EmilyJoan18 @NATrigg @JeremyWilusz @ColinConine
cell.com/molecular-cell/abst…
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Natalie Trigg retweeted
Online Now: A ligation-independent sequencing method reveals tRNA-derived RNAs with blocked 3′ termini dlvr.it/TBQN1g
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Natalie Trigg retweeted
ft. @HarrisOnTheSkin, @NATrigg, Bruktawit Goshu, Yuichi Yokoyama, @Lenka_Dohnal, @EllenWhiteinLab, Adele Harman, @SofiaMurgaG, @_tcpan, @preetibacterium, @ThaissLab, Elizabeth Grice, @ColinConineand & @TakuKambayashi @PennPathLabMed #Derm @PennMicro tinyurl.com/mrxre4b8
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Natalie Trigg retweeted
The Career Consultation Center is back at the 2024 meeting: Meet one on one with an experienced mentor to get advice about your career options and what steps you need to take to put you on a trajectory for success. Indicate your interest when you register!
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Natalie Trigg retweeted
Using the 'Reconstituted Chimeric Follicle' (RCF) system, we found that transzonal projections (TZPs) can re-establish within 3 hours! These TZPs, with their gap junctions, assist young granulosa cells in rejuvenating aged oocytes! biorxiv.org/content/10.1101/…
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Natalie Trigg retweeted
📣 SSR needs YOU! Are you passionate about the #reproductivesciences and looking to make a meaningful impact in the field? Our 2024 Call for Volunteers is now open, and we invite YOU to apply! Applications are open through April 15. Learn more: brnw.ch/21wHVZ5
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Natalie Trigg retweeted
Welcome to read this Editor’s Choice Article👍
The Transmission of Intergenerational #Epigenetic Information by Sperm #microRNAs
👉mdpi.com/2075-4655/6/2/12
@ColinConine
Read the review The Transmission of Intergenerational Epigenetic Information by #Sperm #microRNAs
mdpi.com/2075-4655/6/2/12
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