Nature Cancer is a journal dedicated to publishing the latest advances across all areas of cancer research.
New York, USA
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Our August issue is live!🏖️
Featuring copper dependency in AML, iron-mediated ferroptosis, GPNMB-directed CAR-T cell therapy, IDH1-mutant vaccine in phase 1 trial, and more
🔗nature.com/natcancer/volumes…
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Dr Gong and colleagues report findings from the phase 1 study evaluating L-glutamine + gemcitabine/nab-paclitaxel in untreated advanced PDAC. ORR 44%, including 12.5% CR, with median OS of 22 months. #PancreaticCancer @jgong15
nature.com/articles/s43018-0…
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The neuropeptide galanin impairs antitumor immunity in glioblastoma by interacting with its receptor GALR3 on monocytic myeloid-derived suppressor cells, promoting their infiltration and ferroptosis resistance.
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The full agenda for Reframing Precision Medicine is now live.
We created this event with the goal of moving medicine beyond theory to show how multi-omics, AI, and big data can make truly personalised care the norm.
Join us in London: invt.io/1txbmzq1h21
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The Review on intratumor heterogeneity by @Jonathancmwan, @NickyMcGranahan and @CharlesSwanton
🔗nature.com/articles/s43018-0…
Check out the rest of the Series on Tumor Heterogeneity and Plasticity here: nature.com/collections/gfbbj…
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Join @NancyFGoodman, @Gilles_Vassal and 15 other global experts at our event with @StJudeResearch, looking to address urgent challenges and opportunities in childhood cancer care. Secure a seat and submit an abstract by Aug 6. go.nature.com/4sT18WF
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☀️Check out our July issue !
✅Tertiary lymphoid structures
✅DNA vaccine for GBM
✅CAR T cell therapy in lung metastases
✅adjuvant chemotherapy in nasopharyngeal carcinoma
✅neutrophil-driven contact-dependent immune suppression
✅GABA in GBM
nature.com/natcancer/volumes…
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A micropeptide encoded by the lncRNA USP30-AS1 promotes tumor growth by attenuating cGAS–STING–type I IFN signaling in macrophages
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Nature Cancer retweeted
Great week for the Bruno lab for publications. Check out our new commentary on #TLS in @NatureCancer
@PittTweet @UPMCHillmanCC
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In first-in-human phase 1 NOA16 trial, Platten and colleagues report the long-term clinical and immunological follow-up outcomes of a vaccine targeting mutant IDH1 in persons with astrocytoma. @Platten_lab
nature.com/articles/s43018-0…
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🌻Check out our June issue !
✅Metastatic dissemination in CRC
✅Immunotherapy in GBM
✅BH3 mimetics sensitization in AML
✅ctDNA and PSA to monitor prostate cancer
✅Methylation-based CNS tumor classification
and more
nature.com/natcancer/volumes…
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Zemp at al. found GPNMB as a targetable antigen for MiT/TFE-family fusion-driven soft-part sarcoma and translocation RCC and tested GPNMB-directed CAR T cell therapy in preclinical models and in first-in-human trial.
Read the N&Vs: nature.com/articles/s43018-0…
nature.com/articles/s43018-0…
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🚨Check out our last release
Bayik and colleagues show that inhibition of GABBR signaling extends survival in female glioblastoma models, highlighting the potential for sex-specific cancer treatments and the unique immune landscape shaped by GABA
nature.com/articles/s43018-0…
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Iron level and ferroptosis impair antitumor efficacy of CAR-T cells.
by Dongrui Wang, Yongxian Hu, Pengxu Qian, He Huang & colleagues
nature.com/articles/s43018-0…
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@MoritzGerstung, Felix Sahm & co developed an AI algorithm that leverages H&E slides to classify central nervous system tumors into methylation-based subtypes reducing turnaround time to 12 min in prospective evaluation.
nature.com/articles/s43018-0…
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In a large cohort of patients with ICB-treated glioblastoma, Catherine J. Wu & colleagues show that baseline mesenchymal transcriptional state predicts therapy response, and transition to non-mesenchymal state results in acquired resistance.
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Nature Cancer retweeted
🔥Bacterial engineering for cancer therapy
🆙 @NatureCancer
☑Engineered bacteria as living drug delivery systems for cytotoxics & immunotherapeutics
🎯Payload selection, controlled release & safety optimization are key for clinical translation
🎙Dr. Noah Chen @arpaialab
@OncoAlert @Larvol
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Calling all scientists working on bedside omics, biomarkers, therapeutics, & precision health-related topics. Share your latest findings w/ global experts + @NatureMedicine @NatureCancer & @CommsMedicine editors at our inaugural Flagship.
Submit by 6/30> go.nature.com/4uTnDww
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Delighted to share our @NatureCancer paper, out today, on determinants of ICB response in GBM (link in 🧵)
With bulk and single-nucleus genomic profiling of 181 ICB-treated tumors, we found that tumor RNA subtype (and not TMB!) predicts survival and shapes acquired resistance.
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Excited to share some of my PhD work out today in @NatureCancer! Integrating bulk and single-nucleus genomic approaches, we identify distinct determinants of survival and acquired resistance to ICB versus standard chemoradiation in glioblastoma. nature.com/articles/s43018-0…
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