Pioneering innovations for a better future for people & the planet. Founder & CEO @FlagshipPioneer, the life sciences co that founded @moderna_tx and many more.

Cambridge, MA
Late last week I got @moderna_tx's mRNA vaccines - one each for flu and Covid. Sitting in the @cvspharmacy in Kendall Square, I couldn’t help but reflect on the long and winding road from launching Moderna in 2010 to this moment. Not only have we proven that mRNA vaccines are safe and effective for treating Covid, RSV, and the flu, we are showing that the same technology has significant promise to treat cancer. We are realizing the vision we had so many years ago, of an mRNA platform that we can apply to treat a wide range of terrible diseases. And to see it in action, all I had to do is go to my local pharmacy. Long and winding though the road may be, I have a feeling we’re still only at its beginning. I’m proud of the pioneers at Moderna who have helped get to this point and are working every day to extend the platform to other major unmet medical needs. As an aside: I urge everyone to get your vaccines this fall. It can be easy to forget that flu was once a leading cause of death in the United States. Six years ago Covid killed an estimated 15 million people in 24 months. I don’t take it for granted that we have the tools to take on these viruses - throughout history, most people did not. @CVSHealth products.modernatx.com/finde…
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Looking forward to discussing this new agreement and more with @ForeignPolicy this afternoon in New York. You can watch live here starting at 3:20pm ET: foreignpolicy.com/events/fp-… Breakthrough innovation is the best tool we have to defend against evolving biological threats; this is a new model for the government and private sector to partner to leverage it.
Today, Flagship was awarded up to $47M by the @DeptofWar to advance next-gen medical countermeasures against evolving biological threats. Initial projects include #FlagshipFounded @AprioriBio & @Prologue_Med. Learn more: bit.ly/3T1apjL
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RT @moderna_tx: Today we announced that three abstracts on intismeran autogene, our investigational mRNA-based individualized neoantigen th…
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When we invest in the scientific method and resolve uncertainty with data instead of opinion, we get advances like the new @moderna_tx medicine that’s showing promise to treat cancer in conjunction with @Merck. Glad to join @WalterIsaacson to talk about the science behind mRNA medicines, and what they can tell us about the strengths of the U.S. scientific enterprise. You can watch the full interview here: piped.video/watch?v=KAElBDHp…
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Noubar Afeyan retweeted
From one idea to support reaching thousands of families across #Armenia. 💙 UNICEF & Afeyan Foundation (#AIFA) have worked together to bring psychosocial support closer to children, adolescents & parents. #Foreverychild, partnerships that create lasting change.
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In a new Boston Globe Opinion essay, MIT President Emeritus L. Rafael Reif calls for a simple, globally understood “moral floor” for AI: principles that keep people in ultimate control and prohibit deception, harm, exploitation, and evasion of human oversight. bostonglobe.com/2026/09/02/o…
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Glad to join @LizClaman on @FoxBusiness to discuss the @moderna_tx @Merck clinical trial and what it means for cancer treatment.
Watch now: Flagship Founder & CEO @NoubarAfeyan joins The Claman Report to discuss @moderna_tx and @Merck's mRNA-based cancer therapy.
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RT @moderna_tx: Today we announced that the U.S. Food and Drug Administration has approved the supplemental Biologics License Applications…
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Congratulations to our @ProFoundTx and @gatesfoundation on this innovative investment agreement. Eclampsia and preeclampsia affect millions of mothers and babies each year, but are woefully understudied. Combining this new support from the Gates Foundation with ProFound’s proprietary AI capabilities and knowledge of the expanded human proteome will open new paths to treating these diseases and saving lives around the world.
Today we announced an investment from @gatesfoundation to discover new medicines for preeclampsia/eclampsia. Using our ProFoundry™ Platform & AI, we will explore the expanded proteome to understand the biology affecting mothers & babies at risk. Details: profoundtx.com/news-and-even…
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Pancreatic cancer was long considered one of medicine’s deadliest diagnoses. But today, the FDA approved @RevMedicines' Daraxonrasib - a new treatment that has in trials nearly doubled how long patients survive compared to standard chemotherapy. Daraxonrasib works by targeting a molecule, KRAS, that until now was considered undruggable. The story is a reflection of biotech at its best - pioneering what was once believed impossible, persevering through booms and busts, bringing together enabling research, academic labs, and industry to create breakthroughs for patients and their families.  The FDA deserves our commendation for approving this life-changing treatment with the urgency it demanded, and for moving quickly to allow patients to begin accessing it even before formal approval. Who can say how many lives have been extended - how many more birthdays and weddings and anniversaries will be celebrated - thanks to this wonder of science. Here’s to continuing the momentum on revolutionary new treatments for cancer. wsj.com/health/pharma/fda-ap…
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As a teenager in Montreal listening to “9 to 5,” I never imagined my path would one day cross with Dolly Parton’s. But during COVID, Dolly’s support of Vanderbilt helped fund early tests for Moderna’s vaccine. Later, she encouraged her fans to get vaccinated as only she could (I remember her saying, “Don’t be such a chicken squat, get out there and get the shot!”). Dolly evidently cared deeply about other people and using her platform for good. I like to think she would be proud that the same mRNA research she supported is now showing promise to help treat a whole range of diseases beyond COVID, from the flu to cancer. Her legacy in music and entertainment is obvious, but there are also generations of patients who owe their gratitude to Ms. Parton. Thank you, Dolly. Rest in peace. nytimes.com/2021/03/02/world…
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Glad to join Richard Quest on @CNN to talk about @moderna_tx and @Merck's milestone phase 3 trial results, and what they could mean for patients suffering from melanoma and other cancers. When we choose science, patients benefit.
"We’ve gone from being a cancer focused company, to an infectious disease focused one, and now back to both." Flagship Founder & CEO @NoubarAfeyan joined Richard Quest on @questCNN to discuss the landmark Phase 3 results for @moderna_tx and @Merck's mRNA-based cancer therapy.
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Noubar Afeyan retweeted
Good, concise summary In the trial of over 1,100 patients, every single vaccine was unique, made from the person's tumor antigens gift link wsj.com/opinion/moderna-mrna…
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Today marks an important milestone for @moderna_tx , for the field of mRNA, and for the many people working to bring new possibilities to patients. This morning, Moderna and Merck announced positive Phase 3 results for adjuvant treatment with intismeran autogene, an individualized mRNA therapy for melanoma, in combination with KEYTRUDA, in patients with completely resected stage IIB-IV melanoma. The study met its primary endpoint of recurrence-free survival and a key secondary endpoint of distant metastasis-free survival. This is the first positive Phase 3 result for an individualized neoantigen therapy, and the first for an mRNA-based cancer therapy. When we founded Moderna in 2010, the idea that mRNA could become a new class of medicines was outright rejected. The idea that we might use it to create a therapy designed around the unique mutations in an individual patient’s tumor was even further from reality. Today’s result is a reminder of what can emerge from pioneering: asking questions others have not yet asked, following the science where it leads, and persevering through uncertainty. There is important work still ahead but today is a moment to recognize the extraordinary work behind this milestone. Congratulations to the entire Moderna team, our partners at Merck, and the investigators who made this study possible. Most importantly, my gratitude goes to the patients and families whose participation enables progress like this. Proud of this milestone, and of everyone who helped bring us here.
Moderna and @Merck today announced positive topline results from the Phase 3 INTerpath-001 trial evaluating adjuvant treatment with intismeran autogene, a novel investigational mRNA-based individualized neoantigen therapy jointly developed by Merck and Moderna, in combination with KEYTRUDA® (pembrolizumab), Merck's anti-PD-1 therapy, in patients with completely resected Stage IIB-IV melanoma. Read more:
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When I first immigrated to the U.S., I felt out of place – until I realized that except for Native Americans, everyone in this country is or once was from somewhere else. I enjoyed the @nytimes' compelling analysis of that history, which uses Census data to visualize the immigration patterns that have shaped our country since before its founding. Their conclusion: "Melting pot, tapestry, mosaic, kaleidoscope, salad bowl. Every cliché is true.” For me, whether during my childhood in Lebanon or my adolescence in Canada, I always loved the idea of the United States as a melting pot: all of us from somewhere else, blending together to make a nation. A gift link to the piece is in the comments; I recommend you read it, and hope you take away what I did: immigration is not just what makes America distinct; it is what makes it great.
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RT @moderna_tx: Today we announced that following Health Canada’s authorization of the study, the first participants have been vaccinated i…
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When Flagship engages in more places around the world, we reach more people with our pioneering science and companies. We access new pools of talent. We learn from different perspectives, and we challenge our assumptions in new environments with new partners and collaborators. That is why I am so pleased today to welcome Fidah Alsagoff to lead the next chapter of our expanding global presence. Fidah is a seasoned executive with decades of experience navigating the global life sciences ecosystem. As Executive Partner and Head of Global Initiatives, he will work closely with our exceptional Global team — including Junaid Bajwa in the UK and Andre Andonian in APAC — to expand breakthrough science and cutting-edge companies across geographies and time zones. Welcome to Flagship, Fidah.
Join us in welcoming Fidah Alsagoff to Flagship Pioneering as Executive Partner and Head of Global Initiatives. As Flagship continues to expand its global presence, Fidah will lead the strategy and execution of the company's work across international markets — strengthening scientific partnerships, advancing clinical development opportunities, and helping connect breakthrough innovation across regions. More here: flagshippioneering.com/news/…
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Thank you for your principled stance.
Was asked to go to Azerbaijan for a lecture . I declined (they yuugely upped their offer, not understanding my ethics, thinking it would make a difference). I will not set foot in Azerbaijan with Reuben Vardanyan jailed there.
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