Aging has a language. 🧬 We’re teaching AI to read it. On the cover of Cell: compact Longevity-LLMs, jointly trained by Insilico Medicine and @liquidai, demonstrate SOTA performance on LongevityBench. Powered by these models, Longevity Claw nominated 328 candidate gene targets for aging research. Small model. Big questions. Open source. 🧵👇 #insilicoSOTAFM

Today, we're excited to share early progress on using Gemini to accelerate scientific discovery in the real-world. We present an extension of Co-Scientist which we use to collaborate with scientists across materials science, biology, and computer science.

We are making continuous improvement on Gemini for Biology!

New in @BloodJournal: A comprehensive preclinical study evaluated ziftomenib using leukemia cell lines, primary patient samples, xenografts/PDXs, gene-expression profiling, and structural crystallography. Ziftomenib suppressed MEIS1/HOXA signaling, induced differentiation, and caused leukemia regression in NPM1m/KMT2Ar models. CRISPR-engineered MEN1-mutant models showed retained activity against T349M and G331R—but resistance with M327I/G331D. #AML doi.org/10.1182/blood.202503…

New work from our lab out today in @NatureCellBio led by @jaynathemistry!! nature.com/articles/s41556-0… 🧵 on how clonal hematopoiesis turns the bone marrow niche into an accomplice:

1/6 MYC has long been considered “undruggable.” Instead of trying to drug the protein, we went after its RNA. This work is part of our long-standing effort to expand the druggability of genetically defined disease targets at the level of mRNA.

Our paper, “Prognostic impact of FLT3-ITD microclones in young adults with acute myeloid leukemia treated with intensive chemotherapy”, is now published in @BloodPortfolio 🤩 Many thanks to all co-authors and collaborators! Free access (until Sept. 18): authors.elsevier.com/a/1nWx4…

🔆🔆🔆Matching T-cell receptors (TCRs) to their cognate peptides presented on MHC molecules (pMHCs) from sequence data alone is one of the most important unsolved problems in computational immunology. I've been presenting this work for over a year and am excited to finally share the preprint and public code. A transformative collaboration for our lab with @quaidmorris (see tweetorial 👇👇with links). Led by first authors @Olga_Lyu, Jonathan Levine & Melissa Pathil, with S. Martis, A. Streltsov, Z. Sethna, Y. Elhanati (@elhanati_yuval), Vinod Balachandran (@TheVinodLab)!!! @MSKCancerCenter

In Georgia I entered a Chick-fil-A drive-thru line of forty cars. I turned off my engine. I prepared to wait the way my ancestors waited out a siege. Six minutes later I was holding chicken. I do not know what happened to the other thirty-nine cars. The line moved like water that had somewhere to be. A young woman walked between the cars taking orders on a small tablet, on foot, in the sun, smiling like the sun was her idea. I said thank you. She said, "My pleasure." I did not think about it then. I should have. At the window I thanked the young man for the food. "My pleasure." I thanked him for the sauce. "My pleasure." I thanked him for thanking me— "My pleasure." I want to be clear about what was happening. This was a duel. In Japan I trained in courtesy for forty years. Bowing angles. Seasonal greetings. The correct depth of apology for seventeen distinct situations. I was a white belt in that drive-thru. I escalated. I used my most formal English. I thanked him on behalf of my entire family line. He said, "My pleasure," and gave me extra sauce. Extra sauce. Unprovoked. A counterattack. I returned the next day to reclaim my honor. It was Sunday. The restaurant was closed. All of them were closed. In the entire country. They close every Sunday, and they have closed every Sunday since the beginning, because the founder made a promise, and the promise did not expire when he did. I stood in the empty parking lot and understood I had lost twice. Once to a teenager with sauce. Once to a man I will never meet, who kept his word so long it became a building. In my country we say a samurai's word is his life. I had never seen a restaurant say it back. I returned Monday. I ordered. And this time I said it first, before she could. "My pleasure." She smiled and said, "It sure is." America, I surrender. It was my pleasure.

Researchers from the Crispino Lab Team at @StJudeResearch led by Dr. Jeremy Wen and Anitria Cotton identify menin as a key regulator of #megakaryocyte proliferation and fibrosis in #myeloproliferative neoplasms. Learn more here at @Cancer_Cell: 🔖 bit.ly/4wGXEZy

From proposing hypotheses to designing experiments, AI agents are starting to reshape scientific discovery. But the hardest part is testing these ideas in the real world. Our essay explores the growing validation bottleneck and outlines four priorities for policymakers and funders. → goo.gle/4poACUT

We just updated our manuscript "Understanding Language Model Scaling on Protein Fitness Prediction". Where we explained why larger pLMs don’t always perform better on mutation effect prediction. We extended beyond ESM2 to models like ESMC, ESM3, SaProt, and ESM-IF1. #ProteinLM

Excited to share our study on immune interactions in extramedullary (lung) acute myeloid leukemia (AML) out today at @NatImmunol !! Acute respiratory failure frequently occurs in AML due to leukemia infiltration of the lungs. The question is why and what can we do to suppress it. @VarvaraParask in the lab started this work by mapping AML:stromal and AML:immune cell interactions using scRNA-Seq and Visium/Xenium @10xGenomics spatial tools. nature.com/articles/s41590-0…

We’re introducing GeneBench-Pro, a research-level benchmark for a harder kind of AI progress: how well agents can navigate messy biological data, choose the right analysis path, and make judgment calls that real computational research depends on. openai.com/index/introducing…

scRNAデータのバッチ間の統合など、生命情報科学や公衆衛生学的な解析用ソフトウエアを人間よりうまく生成するAIプラットフォームを構築したという論文。間にLLMgがはまっている。これは読まないと不味そうな気がする。Nature。 nature.com/articles/s41586-0…

Ummm…

Happy to share our new review in @BloodPortfolio, led by Jiaoyi Chen with Benson Wu! We explore how DNA methylation can help retrace a cancer’s history and reveal how tumours evolve and respond to treatment. sciencedirect.com/science/ar…

At Tahoe, one of the reasons we are excited about perturbation prediction is to ultimately predict how patient samples will respond to any of the many drugs in our library

1/ Another single-cell study drops. 500,000 cells sequenced. More UMAP plots. More clusters. But here’s the question: Are we learning more—or just counting better? 🧵

O cofundador do Claude sentou hoje entre cardeais no Vaticano e disse ao Papa: minha indústria opera com incentivos que conflitam com fazer a coisa certa. O Papa olhou para ele e respondeu: "Em nome da Igreja, aceito seu convite para caminharmos juntos." Aconteceu há horas. Leão XIV apresentou a "Magnifica Humanitas": a primeira encíclica papal da história dedicada a uma tecnologia específica. O Papa quebrou séculos de tradição para apresentar o documento pessoalmente. Nenhum papa tinha feito isso antes. E escolheu como convidado o cofundador do lab de IA notavelmente ausente dos contratos militares do Pentágono. A Anthropic se recusou a liberar seus modelos para armas autônomas e vigilância doméstica. O que Olah disse diante de cardeais, teólogos e do líder de 1,4 bilhão de católicos: "Todo lab de IA opera dentro de incentivos que podem entrar em conflito com fazer a coisa certa." Pressão comercial, competitiva e geopolítica. E "as pressões mais antigas e mais simples: orgulho e ambição." A conclusão dele: "As questões levantadas pela IA são maiores que a comunidade de pesquisa em IA." Precisamos de críticos externos sérios e honestos. Agora o documento. A abertura coloca a humanidade diante de duas escolhas: construir uma nova Torre de Babel ou reconstruir Jerusalém. A frase que define a encíclica: "A inteligência artificial precisa ser desarmada." Leão XIV sabe que a palavra é forte. Escolheu de propósito. Parágrafo 110: → "Desarmar a IA significa libertá-la da mentalidade de competição armada, não apenas militar, mas econômica e cognitiva" → "Uma corrida por algoritmos cada vez mais poderosos, movida pelo desejo de dominância geopolítica ou comercial" → "Desarmar não significa rejeitar a tecnologia, mas impedir que ela domine a humanidade" E depois: "Simplesmente regulá-la é insuficiente." O Papa não está pedindo regulação. Está dizendo que regulação não basta. → "A IA amplifica o poder de quem já possui recursos econômicos, expertise e acesso a dados" → O risco não é alguém acreditar que conversa com uma pessoa ao usar IA. É perder o desejo de buscar outras pessoas. → "Toda escolha de design reflete uma visão de humanidade" (parágrafo 111) A simbologia foi calculada em cada detalhe: → Documento assinado em 15 de maio, aniversário exato da Rerum Novarum (1891), a resposta de Leão XIII à Revolução Industrial → O Papa disse explicitamente: "Como o Leão anterior, sinto-me encarregado de olhar para outra enorme transformação com olhos de fé" → A Igreja faz isso a cada grande ruptura: Rerum Novarum (1891), Pacem in Terris (1963, era nuclear), Laudato Si' (2015, clima), agora Magnifica Humanitas Fazer da IA a primeira encíclica do pontificado é dizer que nenhum outro assunto é mais urgente. Agora conecta os pontos. O primeiro Papa americano da história está em conflito aberto com a Casa Branca. Ele traz ao palco do Vaticano o cofundador do único lab de IA que enfrentou o governo Trump em defesa de limites éticos. E juntos publicam um documento de 42.300 palavras dizendo que a tecnologia mais poderosa já criada pela humanidade não pode ficar nas mãos de quem lucra com ela. Teologia e geopolítica na mesma mesa. Literalmente. Quem constrói a IA não pode ser quem define as regras da IA. O Papa e o cara que constrói a IA concordaram nisso hoje. No Vaticano. Diante do mundo.