Paulos Lab@PaulosLab

T cell specialists lab! @EmorySurgery @WinshipAtEmory

 Atlanta, GA
Joined May 2011
600 Photos and videos
Paulos Lab retweeted
Paulos Lab@PaulosLab
6 Oct 2023
Check out Dr. @GuillermoORang1's new Cancer Research paper. We show that not all stem-like memory CD8 T cells are equal... Progressively enhancing stemness of adoptively transferred T cells with PI3Kδ blockade improves metabolism and anti-tumor immunity aacrjournals-org.proxy.libra…
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Newest preprint paper by our team (@LesinskiLab & @pauloslab) in biRxiv! @WinshipAtEmory @sitcancer Clinically relevant orthotopic pancreatic cancer models for adoptive T cell therapy biorxiv.org/content/10.1101/…

Clinically relevant orthotopic pancreatic cancer models for adoptive T cell therapy

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor. Prognosis is poor and survival is low in patients diagnosed with this disease; ∼12% at 5 years. Immunotherapy, including adoptive T...

biorxiv.org
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Excited to announce that this manuscript is officially out in the latest issue of JCI! Thanks again to all the coauthors and of course to my postdoc mentor Don Gibbons for his continual support! The model figure from these studies:
Journal of Clinical Investigation
@jclinicalinvest
5 Sep 2023
Targeting autotaxin enhances immune checkpoint blockade response: buff.ly/44AzwcD @jessica_konen @MDAndersonNews #Immunology #Oncology
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This! Please consider donating to our colleague in her time of need.
Guillermo O. Rangel Rivera@GuillermoORang1
19 Jun 2023
Friends and colleagues, our talented and hardworking technician, Soundharya needs your help! Please help us fundraise for her and her family in her time of need! Share/donate! Any bit will help! Fundraiser for Soundharya Kumaresan gofund.me/f46bc35c
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Paulos Lab retweeted
Zain Kahn
@heykahn
10 May 2023
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☀️A must read by our MSTP student @GuillermoORang1! The degree of T cell stemness differentially impacts the potency of adoptive cancer immunotherapy in a Lef-1 and Tcf-1 dependent manner. biorxiv.org/content/10.1101/…

The degree of T cell stemness differentially impacts the potency of adoptive cancer immunotherapy...

Generating stem memory T cells (TSCM) is a key goal for improving cancer immunotherapy. Yet, the optimal way to modulate signaling pathways that enrich TSCM properties remains elusive. Here, we...

biorxiv.org
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⭐️A must read!!! Congrats to @LesinskiLab & team for stellar work in novel immunotherapy to impact #PancreaticCancer. Just out in @JCI_insight: insight.jci.org/articles/vie…. @sitcancer @ImmunologyAAI @WinshipAtEmory
Gregory Lesinski@LesinskiLab
8 Mar 2023
Our paper is out! Dual IL6/CTLA4 blockade in #PancreaticCancer so many collaborators over many years. @WinshipAtEmory @BwareRedHair @phillipsmaggiej @Chrystal_Paulos @hknochelmann @greeneEMnM @CarsonLabOSU @brobinsonGIpath @TMaceLab @cameron_herting @anruggieri @BasselElRayesMD
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We @PaulosLab honored to be #JITCTop10 for this coolio B cell ACT CD8 T cell paper. ;)
Journal for ImmunoTherapy of Cancer
@jitcancer
29 Dec 2022
Countdown to 2023: #JITCTop10 - B cells imprint adoptively transferred CD8+ T cells with enhanced tumor immunity bit.ly/332sJis @Aubrey_Smith04 @PaulosLab
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Set your life on fire. Seek those who fan your flames. -Rumi
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CD40-activated B cells to the rescue! jitc.bmj.com/content/10/12/e…

Immune responses against shared antigens are common in esophago-gastric cancer and can be enhanced...

Background Specific immune response is a hallmark of cancer immunotherapy and shared tumor-associated antigens (TAAs) are important targets. Recent advances using combined cellular therapy against...

jitc.bmj.com
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CD40 agonism may circumvent a dysfunctional CD4 compartment to improve PD-1 blockade responsiveness, supporting a novel synergistic immunotherapeutic approach.jitc.bmj.com/content/10/12/e…
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Great work from @Zihai and lab. jitc.bmj.com/content/10/9/e0…
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Increased numbers of neutrophils and macrophages associated with cancer progression may be risk factors for anaphylaxis. jitc.bmj.com/content/10/12/e…
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The best of the best of the best, herein!! Woot @AyanaTRuffin
Dr.YayaTheScientist@AyanaTRuffin
15 Nov 2022
#BIIW22 #BlackInImmunoRollCall Hi there! I’m Ayana and I am a postdoc fellow in the @PaulosLab at @WinshipAtEmory . I am currently obsessed with B cells and their best friend CD4 T cells and how we might use both in adoptive cell therapy to treat cancer.
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💥Less is more: @MeganMWyatt’s new manuscript in @biorxivpreprint shows metabolically fit CAR T cells can be generated using fewer activation beads in @PaulosLab w/ @LesinskiLab @ImmuneCellsRUs. Props @GuillermoORang1 @hknochelmann @nelson_CD26 @Aubrey_Smith04 @WinshipAtEmory
bioRxiv@biorxivpreprint
1 Nov 2022
Augmenting TCR signal strength and ICOS costimulation results in metabolically fit and therapeutically potent human CAR Th17 cell therapy biorxiv.org/cgi/content/shor… #bioRxiv
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‘Wolde ye bothe eate your cake, and haue your cake?’ -John Heywood, 1546 Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy pubmed.ncbi.nlm.nih.gov/2432…
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The ⁦@PaulosLab⁩ is VERY thrilled to welcome our #gamechanger postdoc fellow ⁦@AyanaTRuffin⁩ to ⁦@EmoryUniversity⁩ ⁦@WinshipAtEmory⁩!
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… and an essay in the NYT. 7/ nytimes.com/2022/06/20/opini…

Opinion | How Animals See Themselves (Published 2022)

The most familiar of settings can feel newly unfamiliar through the senses of other creatures.

nytimes.com
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#ASCO22 | June 3 | Education Session | Developmental Therapeutics "Tebentafusp for Uveal Melanoma" Panel Speaker: Melinda Yushak, MD, MPH #melsm ➡️ fal.cn/3pawg
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