Our latest work, uncovering the origins of microglia in human aging! Link to article below 👇

Gaining therapeutic access to the human brain is one of the biggest unsolved problems in biomedical science. Today @nature, we uncover a massive influx of immune cells into the human brain during aging, revealing that the brain is more accessible than previously thought. 1/ nature.com/articles/s41586-0…

It's been a while now, but @DrFlashHeart and I are excited to share that our work exploring somatic gene x environment interactions between CHIP and air pollution in lung cancer is now published in @JNCI_Now doi.org/10.1093/jnci/djag159

✨ Thrilled to share our new publication in Nature. We define an “inflammatory memory” HSC state (HSC‑iM), linking lifelong inflammatory exposure to aging and disease. 📄 Article: nature.com/articles/s41586-0… Grateful to an incredible team and global collaborators 💚💙

Very nice CH review series in Hematologica. haematologica.org/issue/view…

New preprint out! We asked: can we tell which CHIP mutations actually matter for disease risk? Analyzing >1 million individuals across @ukbiobank, @AllofUsResearch, and @VUMChealth BioVU — here's what we found. 🧵 (1/9)

📢 Our review on clonal hematopoiesis + evolutionary dynamics using mathematics is now available online @NatureGenet Check it out! #CHIPsm

Happy International Day of Women & Girls in Science! 🌟 Celebrating the brilliant minds breaking barriers, sparking innovation, & inspiring future generations to dream bigger. Here’s to curiosity, discovery, and the power of science! 💡🔬 #WomenInScience #GirlsInSTEM #IDWGS2026

Congratulations, Zil Patel PhD'29 student on your recent award! @QMyPath @QueensuDOM @QueensUHealth

CHIP ahoy: charting a decade of discovery in clonal hematopoiesis | Haematologica haematologica.org/article/vi…

@rheumrob,@AlexBickMDPhD, & I are excited to share that our work is now out in @jclinicalinvest! CHIP epi studies underestimate the association between CHIP & disease using WGS vs deep sequencing. Many thanks to the co-authors, participants, & reviewers! doi.org/10.1172/JCI198861

CHIP was associated with increased heart failure and ischemic cardiovascular disease risk after #cancer therapy in patients with solid tumors, especially among those with higher #chemotherapy exposure. ja.ma/3Nj5vuW

Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development in mice In this Research Letter, Bowen Yan @BowenyanYan, Olga A. Guryanova @gur_ola @UFHealthCancer @UF_Pharmacolo& team @UFMedicine report #ClonalHematopoiesis, an #aging related condition caused by mutations in the #blood system, promotes #obesity, and drives the risk of #diabetes and #MASLD in the context of a high-fat #diet: doi.org/10.1172/JCI197100

📢 Online today: Ancestry-dependent patterns of somatic mosaicism and clonal hematopoiesis mutations in over 125,000 individuals reveal distinct cancer associations rdcu.be/eSROU. A huge feat with pretty figures, driven by #ChristelleColinLeitzinger. 👏

Congrats @DrFlashHeart (Caitlyn Vlasschaert) on your work providing 🩸clonal hematopoiesis 🧬genetic phenotypes for @uk_biobank in conjunction with @AlexBickMDPhD @jaiswalmdphd @pnatarajanmd & others. An incredible resource for the world! #CH #CHIP @QueensUHealth @QueensuDOM biobank.ndph.ox.ac.uk/showca…

Happy to share that our work on TET2 CH in ICI therapy is now out in @CR_AACR! We found that TET2 mutations promote myeloid co-stimulatory programs and suppress T cell exhaustion, contributing to improved immunotherapy response! 🔗Read more here: doi.org/10.1158/0008-5472.CA…

Congrats Alex McDonald on your MSc graduation @tmedQueens ! ! 🎉🍁 You made fundamental discoveries about clonal hematopoiesis and risk of Alzheimer disease, and contributions to this paper @CellStemCell . Amazing!!🤩 doi.org/10.1016/j.stem.2025.…

CHIP variants are often discovered incidentally in liquid biopsy testing, but is plasma cell-free DNA reliable when CHIP variants are the desired finding? 🩸@BloodAdvances @AlexBickMDPhD 🧵1/12

Congratulations to @PMResearch_UHN's Dr. Robert Vanner, who leads a team awarded $1M through @BrainCanada and @SRC_CRS's 2025 Translational Research Grant in Brain Cancer! 🎉 🔗Learn more about the project focused on advancing #glioblastoma research: braincanada.ca/funded_grants…