Ryan Clarke retweeted
"There is perhaps no stronger evidence of the [Trump] administration’s objectives to reduce the quality of the US scientific workforce than its treatment of the National Science Foundation’s flagship Graduate Research Fellowship Program," writes H. Holden Thorp in a new #ScienceEditorial. scim.ag/4coukAg
ALT A quote by H. Holden Thorp, Editor-in-chief of Science journals, on a black background. The quote is: "… why curtail a program … that cultivates and grows the number of US graduate students and future researchers?"
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Ryan Clarke retweeted
This will be absolutely devastating in the medical field.
~30% residents are international medical graduates & ~10k of 43k residency spots are filled by docs with H1-B visas.
Previously the h-1B fee was <$5,000.
No hospital will pay a $100k fee for a $55k resident salary.
Trump signs an EO on H-1Bs raising "the fee that companies pay to sponsor H1-B applicants to $100,000"
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Ryan Clarke retweeted
David Baltimore (March 7, 1938 – September 6, 2025). His discovery of reverse transcriptase, along with Howard Temin and Satoshi Mizutani, illuminated the retrovirus life cycle, led to the discovery of viral oncogenesis mechanisms and antiviral RT inhibitors, and enabled technologies including RT-PCR, RNA-seq, and prime editing.
nytimes.com/2025/09/07/scien…
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The story behind how Generation 3.0 proGuides were engineered. They enable efficient, multi-step, pre-programmed CRISPR activation of endogenous genes.
biorxiv.org/content/10.1101/…
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Thank you for the great article @medcitynews medcitynews.com/2023/09/star…
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Ryan Clarke retweeted
The pioneer of DNA assembly
EcoRI + DNA ligase* = the first recombinant plasmid
I'm sad to share the news of Paul Berg's passing today. Paul was one of the greatest 20th century biochemists who founded @StanfordBiochem. He was a friend and mentor who I will miss dearly. His passion and advocacy for science and education was infectious.
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Ryan Clarke retweeted
Very excited to see our work on Cas9 conformational activation out in @Nature ! nature.com/articles/s41586-0…
What started as a very poor crystal structure back in 2017 in the @MartinJinek lab, turned into a full blown cryoEM project during the pandemic.
ALT Cas9 bathing in its natural glory
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Ryan Clarke retweeted
Here's a bacterium on a diatom on an amphipod on a frog on a bump on the log in the hole in the bottom of the sea [source, read more: bit.ly/2F8fbBC]
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Thank you @tool for spending 1,227 minutes with me this year on @Spotify. You are my #1. #SpotifyWrapped open.spotify.com/artist/2yEw…
Ryan Clarke retweeted
Video of #SARSCoV2 infecting brain cells (gray blobs) with cell fusion, hijacking, and explosive release of copies for more invasions
nytimes.com/2021/08/22/scien… @NYTScience @AndrewJacobsNYT by @aicher_sophie and @Delphine_Planas @institutpasteur @justsaysinrats @NikonSmallWorld
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Our paper is officially out in the latest issue of @MolecularCell
Sequential Activation of Guide RNAs to Enable Successive CRISPR-Cas9 Activities dlvr.it/RrK3dR
Ryan Clarke retweeted
Online Now: Sequential Activation of Guide RNAs to Enable Successive CRISPR-Cas9 Activities dlvr.it/RpYD1c
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Incredible work!
Massively proud of Leo's elegant & thorough study out in NBT, developing CRISPR-transposons for high-efficiency & high-fidelity DNA integration in diverse bacteria. Lots of exciting ideas on advancing this even further, together w/ collaborators @harriswangnyc and @RondaCarlotta
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Ryan Clarke retweeted
Today was a very, very odd day
I testified before @senatehomeland
They held a hearing on hydroxychloroquine.
Yup, HCQ
In the middle of the worst surge of pandemic
HCQ
It was clear how our information architecture shapes questions of science and medicine of COVID
A thread
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Ryan Clarke retweeted
Science is not political. It is not an opponent who can be defeated. Science is simply a philosophy that considers all ideas but moves forward those supported by the best evidence. Battling science is like battling gravity. Doing so during a pandemic is deadly & self-destructive.
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Ryan Clarke retweeted
It is hard to imagine 274 characters more damaging to US efforts to provide medicines for #COVID19 patients, and to provide vaccines for all of us. Sowing distrust of those who work tirelessly to ensure the safety and efficacy of our medicines and vaccines will kill Americans.
The deep state, or whoever, over at the FDA is making it very difficult for drug companies to get people in order to test the vaccines and therapeutics. Obviously, they are hoping to delay the answer until after November 3rd. Must focus on speed, and saving lives! @SteveFDA
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New preprint from my colleagues and I describing automated and sequential genetic manipulations via and engineered Cas9 system #CRISPR #syntheticbiology dlvr.it/RZ3QGL.
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