Postdoc Li lab @ MIT. PhD Ke lab @ Cornell. Studying biology.🧬🧫
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- Following 117
- Followers 55
- Likes 352
Robert Battaglia retweeted
We recently found an unexpected deletion in the amyE-back homology arm commonly used for cloning in B. subtilis -- check out the details in our short preprint: biorxiv.org/content/10.1101/…
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Robert Battaglia retweeted
Excited to share our latest work from @bioSavinov, a K99 fellow in the lab (and corresponding author!). Andrew worked w/ @SassSeabass (@keating_lab) to develop FragFold: a massively parallel computational approach to discover inhibitory protein fragments! Check out his thread:
Want to design genetically encoded inhibitors of your favorite protein? Thrilled to announce our latest work w/ @SassSeabass, @keating_lab, & @GeneWeiLiLab, where we leverage massively parallel AlphaFold predictions to discover peptide inhibitors. biorxiv.org/content/10.1101/…
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Robert Battaglia retweeted
We are happy to share our latest work revealing that pseudouridine is found in bacterial mRNA! biorxiv.org/content/10.1101/….
A short thread: (1/n)
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Robert Battaglia retweeted
We are delighted to share a new method for live-cell transcriptome recording: Molecular Time Capsules!
biorxiv.org/content/10.1101/…
We envision MTCs will help reveal the origins of phenotypic heterogeneity, and facilitate the study of transcriptomes in hard-to-access locations. (1/n)
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Robert Battaglia retweeted
Congrats to Li lab graduate student Manraj Gill on receiving an MIT School of Science DEI Service Fellowship for his deep engagement in the mentorship of underrepresented students both within @MIT and in the broader community! @MITBiology @ScienceMIT
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Robert Battaglia retweeted
What do the #epigenome and #Grogu have in common? Answer: the Force is strong in both of them.
In our latest review (in press) with @dpmelters @NCIYaminiDalal, we discuss how mechanical forces shape chromatin structure, leading to biological functions. osf.io/s2h9j/
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Congrats, Itai!
I'm happy to share our work on computer-aided synthesis planning of hybrid enzymatic/synthetic reaction pathways with @Geneticdesigner and @cwcoley!
nature.com/articles/s41467-0…
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Beautiful structure and mechanism by @ch_hu1 and @AilongK lab!
Caspases control programmed cell death in eukaryotes. Type III-E CRISPR harbors caspase-like proteases. Our new Science paper explains how Craspase switches on protease activity in RNA-guided fashion - safe alternatives to Cas nucleases in therapeutics.
science.org/doi/10.1126/scie…
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Robert Battaglia retweeted
IscB-ωRNA is as active as Cas9 in test tube, but only a fraction in size. Want to learn about their similarity and differences in high-res? What might be holding its activity back in human cells? Further miniaturization? Check out our new publication. science.org/doi/10.1126/scie…
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Awesome and thought-provoking work by Lydia et al!
Check out our, @GeneWeiLiLab @julianstanley_, new paper showing that a large fraction of RNA molecules in bacteria are fragments of canonical full-length mRNAs with consequences for differential RNA-seq analysis: doi.org/10.1093/nar/gkac295
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Robert Battaglia retweeted
Great feature on innovative research from the Ailong Ke lab! research.cornell.edu/news-fe…
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Robert Battaglia retweeted
Sad to learn that #Yale Prof. and colleague #SidneyAltman, 1989 Chemistry #Nobel recipient, has died. His publication on the #ribozyme action of #RNaseP was a milestone discovery in the now exploding field of #ncRNA. The photo shows him celebrating the news of his Nobel Prize.
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Robert Battaglia retweeted
The work of a great scientist and one of my best friends, @vera_rinaldi 🥳
It was always fun to make wild conjectures together as to what could be going on here! Congratulations!
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Robert Battaglia retweeted
Thanks for interviewing me 😊 @WhiteheadInst
In the newest #WhiteheadPostdocProfiles, Jordana Bloom studies how hormonal changes during menopause affect gene expression. In December, she coordinated a Covid-safe lab cookie exchange — where lab members could flex their baking skills & stay connected: wi.mit.edu/news/meet-whitehe…
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Robert Battaglia retweeted
The latest Spotlight piece I've written for the @RNASociety featuring @RNABob . It was great to know Bob and learn about his exciting research on riboswitches!
"It's important to keeping learning... you never know where the inspiration for a breakthrough could come from."
Read more in this month's Spotlight featuring Dr. Robert Battaglia @RNABob, who is a post-doc in Gene-Wei Li's lab at @MIT! rnasociety.org/dr--robert-ba…
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Robert Battaglia retweeted
Pyroptosis is conserved between human and bacteria: caspase-activated gasdermins form pores and protect bacteria from phage
Fantastic collaboration with the Kranzusch lab, now out in @ScienceMagazine
Congrats @TanaWein & @algejohn !
science.org/doi/epdf/10.1126…
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Robert Battaglia retweeted
Finally out-- Intimate look at how an anion can snap-lock a polyanionic riboswitch into a tight pseudoknot to upregulate bacterial #detox machinery: labor of love by postdocs Rajeev Yadav (now @michiganstateu), Julia Widom (now @uoregon) & Adrien Chauvier rdcu.be/cELsB
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Robert Battaglia retweeted
Thrilled to present our latest paper, up now on bioRxiv! biorxiv.org/content/10.1101/…
Interested in mapping interaction interfaces of your favorite protein in vivo, or developing inhibitors of those interactions? Curious about regulation by small proteins/miniproteins? A thread (1/n)
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