What if we could turn the tumor’s deadliest tricks against it? New @Cancer_Cell: Tumor-antigen-independent targeting of solid tumors by armored macrophage-directed anti-TREM2 CAR T cells. Led by @GalYagel, @D_Rimini & @MVLocquenghien (1/15) cell.com/cancer-cell/abstrac…

Happy to share our new preprint! We uncovered the full diversity of bacterial TIR-based antiviral immune signaling, massively expanded the known diversity of Thoeris systems, and revealed conservation of TIR-derived immune signals across the tree of life go.bsky.app/redirect?u=https…

📢 Preprint out! Together with @reneechang and the amazing @SorekLab , we explored viral sponges to map their diversity and function. Discovered huge diversity, including sponges that inhibit Pycsar & Type IV Thoeris! biorxiv.org/content/10.1101/…

📢Preprint out! Excited to share my final work from the @Soreklab! We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery. Found 3 new families targeting immune signaling!

Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases In new @arcinstitute work, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement

Excited to share our latest on the Type II Thoeris system! In collaboration with the Sorek and Kranzusch labs, we identify His-ADPR as a signaling molecule. Huge thanks to all involved—amazing teamwork! nature.com/articles/s41586-0…

🗓️Tomorrow! Ariel Cohen, VP Development Projects will present "The Challenges & Opportunities of the Development Pathway for Phage Therapy" 🦠at the Antimicrobial Chemotherapy Conference 2025, join virtually 14:35 CET! Register👉 bsac.eventsair.com/antimicro… #PhageTherapy #Antibiotics

Another cADPR isomer involved in bacterial immunity has been discovered. For me, N7 was the least expected position; I was sure it would be N3, but no... So, there are two more positions for cyclization that should be discovered: N3 and -NH2. More Thoeris systems are waiting! :)

Congrats our very own @Sys_Immunology member PI @TanaWein for the impressive new paper @Nature together with @SorekLab- Shedding yet another piece of the (inflammasome-related) origins of immunology in bacteria!! Proud of you Tana and team! nature.com/articles/s41586-0…

Now published @ScienceMagazine: TIR signaling activates caspase-like immunity in bacteria We report a new immune molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase Congrats @FrancoisRousset & @IlyaOsterman! science.org/doi/10.1126/scie…

We just posted a new preprint where we found retrons in bacteria out in the real world, in dirt and water. We describe the first retrons in a handful of new species, show how they defend against phages, and use them to edit genomes. Read about it here: biorxiv.org/content/10.1101/…