ALT Deconvolution analysis unveils the immune cell composition across four distinct clusters. A, Schematic illustration of deconvolution analysis of whole-blood transcriptomic data. Cell type deconvolution was performed using CybersortX with the LM22 (22 immune cell types) as the signature matrix. The figure was created at www.biorender.com. B, Dot plot demonstrating associations between immune-cell types and each cluster of aPLpositive patients. C, Dot plot showing associations between pathway-specific gene modules and immune-cell types. Only associations that remain statistically significant after multiplecomparison adjustment are displayed

ALT Mark Hall smiling and holding a calico cat, standing in a room decorated with University of Michigan memorabilia.

ALT An illustrated image showing two large, heart-shaped structures with workers scaling and chipping away at the inner walls. The hearts are depicted as rough, jagged terrains with cracks and rocky textures, symbolising damage. Workers use tools like pickaxes and ropes, representing efforts to repair or manage heart damage. The left heart appears more damaged, with more workers actively working, while the right heart shows slightly less damage and fewer workers. The image visually represents the concept of inflammation and repair in heart disease.