We are saddened by the loss of G&D's long-time Editor, Terri Grodzicker. When Terri stepped down as Editor in 2022, friends and colleagues wrote about her contributions to the research community. We are re-visiting these pieces, and thinking of her. ➡️ genesdev.cshlp.org/content/3…

Congratulations to Vishva for all his groundbreaking discoveries !

We’re hiring! 📣 Faculty positions are open at @CBE_Penn @PennEngineers @Penn this year. Apply now and join us! cbe.engineering.upenn.edu/ab…

Mechanism of K63-linked polyubiquitin recognition and cleavage by the BRCA1-A complex dlvr.it/TTyPTd (RSS) #nature #MassSpecRSS

New research out in @ScienceAdvances finds TRF2 couples muscle stem cell identity to regenerative repair ft. Ji-Hyung Lee, Foteini Mourkioti (@PennOrtho), Ryan Calhoun, Patrick Seale (@PennCDB/ @PennIDOM) & @RogerRogergr (@Penn_CBIO) @IRM_UPenn science.org/doi/10.1126/scia…

New research out in @NatureComms finds that the BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells ft. @arindam_datta1, Yaroslav Morozov, Jinghan Qiu & @RogerRogergr (@Penn_CBIO) @PennGenomeInteg @BasserBRCA nature.com/articles/s41467-0…

Meet Ralph Weichselbaum, MD, Chair of Radiation and Cellular Oncology and a leading radiation oncology expert. Follow him for insights on oligometastatic cancer, translational research and advances in cancer care. @rweichselbaum @UChicagoRadonc ow.ly/JBTY50ZjM95

A $10M gift will accelerate the development of a new therapy aimed at treating retinal vasculopathy with cerebral leukoencephalopathy (RVCL), a rare genetic and fatal disease with no cure. @rvcl_research @miner_lab spr.ly/6013BEDbU9

We're thrilled to announce PCGI Postdoc, Arindam Datta (Greenberg Lab), has published work showing that the BRCA1-A complex blocks replication fork reversal to restrict DNA end resection, defining the molecular basis of chemotherapy response in ATM-mutated cancers:

Excited to share our review of molecular regulation/dysregulation of the cGAS/STING pathway. Kudos to co-authors Min-Guk Cho, Rachel Lee, and Jayce Johnson for leading this effort! @UNC_Lineberger @UNC_BCBP

G&D's Editorial Board plays an important role in ensuring we publish cutting-edge research of the highest quality. We are pleased to welcome six new early-career investigators to our Editorial Board. Learn more about the journal: ➡️ genesdev.cshlp.org/

I am pleased to share the final piece of work from my time in the Wolberger Lab. Led by undergraduate Yash Bhargava, we performed a benchmark of AF3 on nucleosome-containing structures. Thank you to @CWolberger for allowing me to build this project up! biorxiv.org/content/10.64898…

Really exciting work from the #Binder/@DrORourke2 group @PennNSG + collaborators highlights how intracerebroventricular CAR-T doesn’t exert anti-tumor effects in isolation but is heavily influenced by the balance of specific cell populations in the CSF.

Congratulations to one of our PCGI trainees, Haoyang Jiang!

Like many scientists of my generation, I entered the cell death field inspired by the work that came from Genentech, especially from @dixitvishva , Kim Newton, and their colleagues. Their discoveries did more than define apoptosis, necroptosis, pyroptosis and inflammatory signalling. They showed us what rigorous, elegant, and transformative science looks like. They also demonstrated that deep, curiosity-driven basic research could thrive within biotechnology and change medicine. Watching these departures is therefore not just news. For many of us, it feels personal. Yet the cell death field has taught us an important lesson: death is rarely the end of the story. In biology, death creates opportunities for renewal, adaptation, and transformation. The scientific legacy built by these extraordinary scientists cannot be erased by a reorganisation chart. Their discoveries have shaped an entire field and inspired generations of researchers who will carry those ideas forward. This is not the end. #GenerationDixit linkedin.com/posts/gianmaria…

Thrilled to announce that postdoc, Haoyang Jiang, has been awarded an NCI Pathway to Independence Award (K99/R00) for his project, "BLM-Driven Recombination at Alternative Lengthening of Telomeres and Non-Telomeric Sites." Congratulations Haoyang on this well deserved award!

@biorxivpreprint Identification of highly immunogenic endogenous dsRNAs from cellular MDA5 filaments biorxiv.org/content/10.64898… @QinA2I @PennGenetics @RogerRogergr

A terrific perspective from Ivan Dikic linkedin.com/feed/update/urn…)