🚨 We’re hiring a postdoctoral research associate! 🚨 The Ryan Lab at Trinity College Dublin is recruiting a Postdoctoral Research Associate to join our new team in the School of Biochemistry and Immunology, based in the Trinity Biomedical Sciences Institute for 2026/2027. This is a great opportunity for scientists with a PhD interested in mitochondrial biology, immunology, inflammation, infection, metabolism, or primary mitochondrial disease. The position will be available for 2 years in the first instance with the potential for extension. The role will aim to understand how pathogenic mitochondrial DNA mutations reshape the innate immune response to infection ex vivo and in vivo. The successful candidate will contribute to a programme involving: 🧫 Primary macrophage culture 🐭Mouse model-linked infection studies 🔥 Inflammatory and infection-associated assays 📊 Cytokine, metabolic, and immunological readouts 🧬 Molecular biology and genotyping 🔬 A growing programme in mitochondrial immunometabolism 📍 Location: Trinity Biomedical Sciences Institute, Trinity College Dublin 📅 Anticipated start: Flexible, ideally November 2026-January 2027 ⏰ Closing date: 12 noon, 07 October 2026 Please share widely and do get in touch if you think you might be a great fit! To apply: Applicants should submit a full CV plus a short cover letter to include the names and contact details of 2 referees (including email addresses), to:- Dr. Dylan Ryan ryand67@tcd.ie Please use the subject line: Postdoctoral Research Fellow Application – Ryan Lab. Important: Applications by private Social Media messages will not be considered and will not be responded to. Only applicants invited to interview will hear back from us.

Good Sunday, all! A wonderful summary of papers in #cancermetabolism and #mitochondrialbiology is out. Don't miss it! biomed.news/bims-camemi/2026… @Bims_BiomedNews @mitoworld_org #keepreading

Nature research paper: TRAM promotes Toll-like-receptor-free myddosome signal transduction go.nature.com/4xIunhq

Happy Sunday with a new edition of Mitochondria in Health and Disease! Full edition online: biomed.news/bims-mitdis/2026… See below for highlights 👇 @Bims_BiomedNews @gavinmcstay2 @mitoscientist @mitoscientists @MitoSociety @Mitochondria411 @MitoAging @mitoworld_org @Mito_News

#Mitochondria & #aging #neurodegenerativedisease #kidneydisease & much more #mitochondrialdisease insights from @_CVasilescu in this week's @Bims_BiomedNews curation. Check it out: #mitoscientists @UMDF #mtDNA #mitochondrialtransplantation

This paper is important: physoc.onlinelibrary.wiley.c…

Completely insane Natire paper…salt increases immunity to #Cancer pmc.ncbi.nlm.nih.gov/article…

Today, the Toll-like Receptors reveal a new mechanism of signal transduction: Receptor-Free Signal Transduction. nature.com/articles/s41586-0…

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews mitoworld.org ⬇️⬇️⬇️ biomed.news/bims-imicid/late… Interesting highlight: ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance Cell Press

SURPRISE! Key interferon-stimulated genes (ISGs) can be induced without interferon! Sounds like an oxymoron, but it is true! Read the paper to find out more. Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activation: Cell cell.com/cell/fulltext/S0092…

at ucsf

Viral infection activates the IRF1-BAK axis to drive mitochondria-derived inflammation dlvr.it/TVWDvl

Two new papers from us and collaborators reveal how the Batten disease protein CLN8 catalyses a key step in BMP synthesis: nature.com/articles/s41556-0… nature.com/articles/s41556-0… Thanks to @CunqiYeLab for a great summary and for putting our findings in context! nature.com/articles/s41556-0…

Why is glutathione, rather than cysteine, the major cellular thiol? Our new work by @ToshiNakamura51 suggests unlike other amino acids, excess cysteine is intrinsically toxic to mammalian cells via mitochondrial iron accumulation. @RockefellerUniv nature.com/articles/s42255-0…

Lactate is toxic. Lactate causes fatigue. High lactate is bad. We hear some version of this all the time. But how much of it is actually true? So we wrote a review separating what we know about lactate from what we’ve simply assumed for decades. Led by our fantastic postdoc Bhavya Blaze! @Bhavya391554759 onlinelibrary.wiley.com/doi/… #Lactate #Metabolism #ScienceTwitter

📢 Last weeks #immunometabolism discoveries @Bims_BiomedNews @mitoworld_org ⬇️⬇️⬇️ biomed.news/bims-imicid/late… Interesting finding: Glutamine-dependent biosynthetic pathways fuel autoreactive T and B cells in Foxp3 deficiency–mediated disease

🧬 Succinate is more than a metabolite. New work in @ScienceAdvances shows that SUCNR1 regulates hepatic metabolic flexibility, glucose oxidation & adaptation to feeding. Its loss increases gluconeogenesis and shifts anaplerosis toward glutamine science.org/doi/10.1126/scia…

We have a new book, and it is a cute one! "Cell Mates" is the alphabet book all #immunology parents need! amazon.co.uk/dp/1066702837/

Mitochondrial ATP promotes T cell differentiation through chromatin accessibility #mitochondria #immunometabolism share.google/opdKGFCs3cFB3es…

Good morning, all. Many groundbreaking discoveries in #cancermetabolism and #mitochondrialbiology here: biomed.news/bims-camemi/2026… @Bims_BiomedNews mitoworld.org #keepreading "Let come what comes, let go what goes. See what remains."-Ramana Maharshi