Rush Announce May 2027 Residency at Las Vegas Sphere Full details: news.cygnus-x1.net/2026/11/r…

🧠 In postmortem brain tissue of patients with #Schizophrenia, the dorsal claustrum showed extensive transcriptome alterations, with upregulation of immune response genes and downregulation of mitochondrial and oxidative phosphorylation genes. ja.ma/3V5Cvev

Dreadds work in humans nejm.org/doi/full/10.1056/NE…

RIP Captain...

In this episode of #BetterEdge, Shan H. Siddiqi, MD (@shansiddiqi), discusses how connectivity-based, image-guided #TMS is advancing precision treatment for #depression, #anxiety and other #NeuropsychiatricDisorders, with recent trial data demonstrating substantially improved response rates. Dr. Siddiqi also explores emerging applications in #PTSD, #OCD and #BipolarDisorder, and highlights Northwestern Medicine's evolving interventional #psychiatry program. Listen now: breakthroughsforphysicians.n…

Amygdala excitability across development: mechanisms, environmental influences, and behavioral outcomes: Trends in Neurosciences cell.com/trends/neuroscience…

So excited to finally share this collaborative work exploring the role of CADM2 recursive splice site deletions led by @Philip_M_Boone. We (@JKhokharLab) were fortunate to characterize the neural and behavioural consequences of CADM2 RS1 deletion cell.com/cell-reports/fullte…

A vasopressin gate transforms social distress into caregiving: doi.org/10.1172/JCI210876 Jonathan P. Fadok @Tulane comments on Geng et al.: doi.org/10.1172/JCI204317 #Neuroscience #SocialBehavior

As we congratulate 🏅 Karl Deisseroth, Peter Hegemann, and Georg Nagel for the #NobelPrize in Physiology or Medicine 2026 on optogenetics, we’re excited to revisit: Karl Deisseroth, Peter Hegemann, and Dieter Oesterhelt receive the 2021 Albert Lasker Basic Medical Research Award: doi.org/10.1172/JCI154418 “My plan was to purify the rhodopsin from this Chlamydomonas creature, and I thought I could do it in a year. But it took me 15 years, actually.”—Peter Hegemann

A few years ago Yavin Shaham and Marina Wolf asked me if we had ever tracked pain longitudinally in our addiction-like behavioral model in HS rats. I was shocked and even ashamed that we had not, so we did it ;-) then took a while to replicate data and publish. We followed pain for 3 weeks of abstinence after oxycodone IVSA. Rats with mild addiction-like behavior recovered in a few days, like saline controls. Rats with severe addiction-like behavior were still hurting at 3 weeks. Opioid-induced hyperalgesia/allodynia is likely a driving force for opioid seeking during the first 3 weeks, but only in SOME individuals, those with the most severe addiction-like behavior. Milder forms may not need that negative reinforcement process or other forms of negative reinforcement are at play (emotional, other type of pain) Thanks Yavin and Marina for the initials spark of curiosity, and big thanks to Lani Tieu and Sonja Plasil who lead these studies Full blog post: oliviergeorge.com/news/2026-… Paper: doi.org/10.1016/j.neuropharm… @PsychiatryUcsd @UCSanDiego @NIH

**Recruitment** We are looking to hire a psychiatrist/scientist (MD or MD/PhD) who focuses on neuromodulation, particularly rTMS in the Department of Psychiatry at the University of Calgary. Come join myself, @MayoOnTheBrain and more. Details 👇 careers.ucalgary.ca/jobs/182…

New lab paper led by @farhana_yasmn describing potential new mechanisms underlying context-dependent adverse anxiety effects of cannabinoids... nature.com/articles/s41467-0…

I'm thrilled to announce that our Preclinical Addiction Research Consortium just got upgraded to a brand new P50 NIDA Center of Excellence, and became the Polysubstance Addiction Research Center. Seven years in the making! drugaddictionresearch.org/ We're studying cocaine, oxycodone, and alcohol in the same individuals, from genes to brain to gut. Then we test whether changing the biology changes the behavior. So thankful for this amazing team: Christine Cheng, Francesca Telese, Lieselot Carrette, Ben McKenna, Cristina Llorente, Bernd Schnabl, Giordano de Guglielmo, Kathleen Fisch, Abraham Palmer, Nick Hollon, and Lisa Maturin and Paul Schweitzer, who keep it all running. I'm immensely thankful for the support of NIDA Enough celebrating. Back to work! today.ucsd.edu/story/uc-san-… @NIH @NIDAnews @UCSanDiego @PsychiatryUcsd

NEW: The anterior hypothalamic nucleus acts like a volume knob for stress, scaling the brain’s response to threatening events 🧠 Read the Cai Lab's latest paper, led by Zach Pennington, in @Nature 🎉 nature.com/articles/s41586-0… More:

Congrats to @fergilmills for leading our paper which just came out today in @NeuroCellPress Amygdalostriatal transition zone neurons encode sustained cue responses to guide defensive behaviors: Neuron cell.com/neuron/fulltext/S08…

Our new review is out now on the ventral hippocampus, highlighting a large body of recent work, from the information it represents to how internal state shapes its activity to how its circuits influence behavior.

The ventral hippocampus: computations, circuits and functions — a Review by Jeremy S. Biane, Julian Wagner-Carena & Mazen A. Kheirbek @jeremy_biane @jawagnercarena @mazen_kheirbek nature.com/articles/s41583-0…

Excited to share our new Cell Reports paper on paratenial thalamus (PT), which identifies a molecular marker for PT and shows how PT interacts with the medial prefrontal cortex, nucleus accumbens, and basolateral amygdala, all done by my student Nigel Dao: sciencedirect.com/science/ar…

FGFR1 in central amygdala PKCδ+ neurons promote punished alcohol drinking (using AAV and small-molecule). This data replicates earlier work from the Barak lab in the dorsomedial striatum, using the same inhibitor, but that time was on regular drinking, so likely not a compulsive-like-specific effect but that's irrelevant IMO. independent convergence across labs is great. My caveat though is that I am always worried about chronic manipulation of growth factor systems but that's my own bias. Great work @Heilig_Lab doi.org/10.1038/s41467-026-7…

Social isolation recruits amygdala–medial prefrontal cortex projections to escalate alcohol drinking in male mice | Nature Neuroscience nature.com/articles/s41593-0…