Wondered why different synapses have distinct presynaptic Cav2 subtype composition? Read our paper @JPhysiol by grad student @jianing59966408
doi.org/10.1113/JP284957
We define the motifs in Cav2 α1 subunit that control subtype and preference
@UIowaResearch @UIowaNeuro
Jan 16, 2024 · 3:48 PM UTC
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We thank @NIDCD @NIH_NINDS @ncats_nih_gov, a predoctoral fellowship from @American_Heart to Jianing and @uihealthcare for funding this work.
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Presynaptic CaV2 subtype abundance regulates neuronal circuit properties, although the mechanisms regulating presynaptic CaV2 subtype abundance and preference remain enigmatic.
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The CaV α1 subunit determines subtype and contains multiple motifs implicated in regulating presynaptic subtype abundance and preference.
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The CaV2.1 α1 subunit domain II–III loop and cytoplasmic C-terminus are positive regulators of presynaptic CaV2.1 abundance but do not regulate preference.
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The CaV2.3 α1 subunit cytoplasmic C-terminus negatively regulates presynaptic CaV2 subtype abundance but not preference, whereas the CaV2.2 α1 subunit cytoplasmic C-terminus is not a key regulator of presynaptic CaV2 subtype abundance or preference.
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The CaV2 α1 subunit motifs determining the presynaptic CaV2 preference are distinct from abundance.
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