Deciphering cellular and molecular mechanisms of synaptic function and impact on neuronal circuit output. Viral vector development and CNS gene therapy.
Iowa City, IA
- Tweets 823
- Following 480
- Followers 853
- Likes 1,605
samyounglab retweeted
Delighted to share our new Nature paper: rdcu.be/dNlMQ
This works shows a surprising off-target effect of glutamate on another cell death channel, acid sensing ion channels (ASICs). It turns out that glutamate directly binds to ASICs as a positive allosteric modulator
10
13
42
7,760
Amazing findings !!
Congrats you and the team
Delighted to share our new Nature paper: rdcu.be/dNlMQ
This works shows a surprising off-target effect of glutamate on another cell death channel, acid sensing ion channels (ASICs). It turns out that glutamate directly binds to ASICs as a positive allosteric modulator
2
702
samyounglab retweeted
So for those of you interested in what it was that I took issue with in Hubermans first cannabis podcast, this is the Coles notes of the errors/inaccuracies that I noted. A lot of this is covered in the new episode, but some wont make it through and for others this is the TLDR
New Huberman Lab podcast out now:
CANNABIS: EFFECTS ON HEALTH & RISKS w/guest @canna_brain
•THC, CBD Biology
•Cannabis & Psychosis
•Is THC addictive?
•Are Strain Differences Real or Placebo?
•Appetite, Hormones
•Dosage Control: Inhaled vs Edible
hubermanlab.com/episode/dr-m…
28
81
630
315,147
Love cellular and molecular neuro. We are hiring a staff scientist interested in building framework of molecular principles for accurate sound information encoding and contribution to auditory deficits.
unc.peopleadmin.com/hr/posti…
Must have background in patch clamp
DM or email
3
9
2,624
Big news. We are moving.
I have officially started as the Director of the Gene Therapy Center, and as a Professor of Pediatrics and Professor of Pharmacology at UNC-Chapel Hill. I am returning “home” to lead the Center where I earned my PhD.
17
5
178
20,132
Amazing paper!!! Congratulations to you and John and the team.
Check it out: most beautiful images of vATPase with a surprising partner on live synaptic vesicles from my brilliant colleague John Rubinstein and his team at SickKids Reaearch Institute & University of Toronto!
science.org/doi/10.1126/scie…
1
1,331
Using a “humanized” hCD46 mouse model, we demonstrate these Ad vectors transduce cerebellar cell-types, including Purkinje cells, that are refractory to Ad5 transduction.
1
6
529
We thank @FamilieSCN2A @scn2agene @cacna1a @ncats_nih_gov @NIH_NINDS @NIDCD @uihealthcare @uiowaOUR funding this research We thank @UIowaACB @UIowaNeuro @UIowaResearch for creating an amazing environment for carrying out high risk high reward research
1
7
479
Finally, I want to thank Dr. Emre Kul, Uchechi Okorafor @MissSafie and the rest of the team for taking on this immense challenge to solve a fundamental problem in the gene therapy field.
1
4
394
The CaV2.1 α1 subunit domain II–III loop and cytoplasmic C-terminus are positive regulators of presynaptic CaV2.1 abundance but do not regulate preference.
1
1
6
772
The CaV2 α1 subunit motifs determining the presynaptic CaV2 preference are distinct from abundance.
1
1
4
519